Patil SB, Tamirat M, Khazhidinov K, Ardizzoni E, Atger M, et al.
2023-11-30 • Trials
2023-11-30 • Trials
BACKGROUND Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yi...
Bonnet MMB, Vasiliu A, Tchounga BK, Cuer B, Fielding K, et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing chi...
Mafirakureva N, Tchounga BK, Mukherjee S, Youngui BT, Ssekyanzi B, et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children. The CONTACT trial found in...
Joshi B, De Lima YV, Massom DM, Kaing S, Banga MF, et al.
2023-10-11 • PLOS Global Public Health
2023-10-11 • PLOS Global Public Health
Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries. How...
Jindani A, Atwine D, Grint D, Bah B, Adams J, et al.
2023-09-01 • NEJM Evidence
2023-09-01 • NEJM Evidence
BACKGROUND Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid a...
Bonnet MMB, Nordholm AC, Ssekyanzi B, Byamukama O, Orikiriza P, et al.
2023-03-23 • Pediatrics
2023-03-23 • Pediatrics
BACKGROUND AND OBJECTIVES: Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mor...
Gunasekera KS, Marcy O, Muñoz J, Lopez-Varela E, Sekadde MP, et al.
2023-03-13 • Lancet Child and Adolescent Health
2023-03-13 • Lancet Child and Adolescent Health
BACKGROUND Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm d...
Bonnet MMB, Gabillard D, Domoua SK, Muzoora C, Messou E, et al.
2023-03-08 • Clinical Infectious Diseases
2023-03-08 • Clinical Infectious Diseases
BACKGROUND In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the perf...
Marcy O, Wobudeya E, Font H, Vessière A, Chabala C, et al.
2023-03-01 • Lancet Infectious Diseases
2023-03-01 • Lancet Infectious Diseases
BACKGROUND Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...
Hayrapetyan A,
et al.
2015-02-01 • American Journal of Respiratory and Critical Care Medicine
2015-02-01 • American Journal of Respiratory and Critical Care Medicine
Ardizzoni E, Orikiriza P, Ssuuna C, Nyehangane D, Gumsboga M, et al.
2019-10-16 • Journal of Clinical Microbiology
2019-10-16 • Journal of Clinical Microbiology
Background: Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries. We aimed to assess ...
Nackers F, Huerga H, Espie E, Aloo AO, Bastard M, et al.
2012-03-12 • PLOS One
2012-03-12 • PLOS One
Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned. ...
Sputum microscopy is the only diagnostic for tuberculosis (TB) available at peripheral levels of health service in resource-poor countries. Its sensitivity is reduced in high HIV-prevale...
Bonnet MMB, Sizaire V, Kebede YYK, Janin A, Doshetov D, et al.
2005-10-01 • International Journal of Tuberculosis and Lung Disease
2005-10-01 • International Journal of Tuberculosis and Lung Disease
SETTING: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance. OBJECTIVE: To discuss the r...
Bonnet MMB, Bhatt NB, Baudin E, Silva C, Michon C, et al.
2013-04-01 • Lancet Infectious Diseases
2013-04-01 • Lancet Infectious Diseases
BACKGROUND In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antitube...
2007-09-01 • International Journal of Tuberculosis and Lung Disease
2007-09-01 • International Journal of Tuberculosis and Lung Disease
SETTING: Urban health clinic, Nairobi. OBJECTIVE: To evaluate the impact on tuberculosis (TB) case detection and laboratory workload of reducing the number of sputum smears examined and ...
Bonnet MMB, Nansumba M, Bastard M, Orikiriza P, Kyomugasho N, et al.
2017-08-02 • Pediatric Infectious Disease Journal
2017-08-02 • Pediatric Infectious Disease Journal
BACKGROUND Mortality among children with presumptive tuberculosis (TB) empiric TB treatment can be high. We describe the predictors of death among children with presumptive TB, and t...
