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Outcome of children with presumptive tuberculosis in Mbarara, rural Uganda | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Outcome of children with presumptive tuberculosis in Mbarara, rural Uganda

Bonnet MMB, Nansumba M, Bastard M, Orikiriza P, Kyomugasho N, Nansera D, De Beaudrap P, Kiwanuka JP, Kumbakumba E
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Abstract
BACKGROUND
Mortality among children with presumptive tuberculosis (TB) empiric TB treatment can be high. We describe the predictors of death among children with presumptive TB, and the relation between treatment and mortality.

METHODS
A prospective cohort of children with presumptive TB who underwent clinical assessment, chest radiograph, tuberculin skin test and sputum bacterial tests for TB was followed up for 3 months. TB diagnosis was based on mycobacterial, clinical and radiologic findings. Predictors of deaths were determined using cox regression model.

RESULTS
Of 360 children included in the analysis, 31.4% were younger than 2 years; 31.6% were HIV infected and 11.3% were severely malnourished. One hundred forty (38.9%) were diagnosed with TB, 18 (13%) of whom were bacteriologically confirmed. At 3 months of follow up, 25 of 360 (6.9%) children had died: 15 of 140 (10.7%) were receiving TB treatment versus 10 of 220 (4.5%) were not receiving treatment (P = 0.025). Severely malnourished children [adjusted hazard ratio (aHR), 9.86; 95% confidence interval (CI): 3.11-31.23] and those with chest radiographs suggestive of TB (aHR, 4.20; 95% CI: 0.93-19.01) were more likely to die. Children receiving empiric TB treatment had an increased risk of death (aHR, 2.37; 95% CI: 1.01-5.55) compared with children without treatment after adjustment for age, sex, HIV status and Bacillus Calmette-Guérin (BCG) vaccination.

CONCLUSIONS
The high mortality in children receiving empirically TB treatment highlights the difficulty in diagnosing childhood TB, the increased likelihood of starting treatment in critically ill children and in children with chronic disease, and the possibility of misdiagnosis. It strengthens the need to invest further in early TB detection and diagnosing nonsevere illness.

Countries

Uganda

Subject Area

tuberculosispediatrics

Languages

English
DOI
10.1097/INF.0000000000001727
Published Date
02 Aug 2017
PubMed ID
28787386
Journal
Pediatric Infectious Disease Journal
Volume | Issue | Pages
Volume 37, Issue 2, Pages 147-152
Issue Date
2018-02-01
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