logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5153.produseast1
Reduced tuberculosis case notification associated with scaling up antiretroviral treatment in rural Malawi | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Reduced tuberculosis case notification associated with scaling up antiretroviral treatment in rural Malawi

Zachariah R, Bemelmans M, Akesson A, Gomani P, Phiri K, Isake B, van den Akker T, Philips M, Mwale A, Gausi F, Kwanjana J, Harries AD
Download

Similar Content
Loading...
Loading...
Loading...
Abstract
OBJECTIVE
To report on the trends in new and recurrent tuberculosis (TB) case notifications in a rural district of Malawi that has embarked on large-scale roll-out of antiretroviral treatment (ART).

METHODS
Descriptive study analysing TB case notification and ART enrolment data between 2002 and 2009.

RESULTS
There were a total of 10 070 new and 755 recurrent TB cases. ART scale-up started in 2003, and by 2007 an estimated 80% ART coverage had been achieved and was sustained thereafter. For new TB cases, an initial increase in case notifications in the first years after starting ART (2002–2005) was followed by a highly significant and sustained decline from 259 to 173 TB cases per 100 000 population (χ2 for trend 261, P < 0.001, cumulative reduction for 2005–2009 = 33%, 95%CI 27–39). For recurrent TB, the initial increase was followed by a significant drop, from 20 to 15 cases/100 000 (χ2 for linear trend = 8.3, P = 0.004, constituting a 25% (95%CI 9–49) cumulative reduction between 2006 and 2009. From 2005 to 2009, ART averted an estimated 1164 (95%CI 847–1480) new TB cases and 78 (95%CI 23–151) recurrent TB cases.

CONCLUSIONS
High ART implementation coverage is associated with a very significant declining trend in new and recurrent TB case notifications at population level.

Countries

Malawi

Subject Area

tuberculosismodels of careHIV/AIDS

Languages

English
DOI
10.5588/ijtld.10.0666
Published Date
01 Jul 2011
PubMed ID
21682967
Journal
International Journal of Tuberculosis and Lung Disease
Volume | Issue | Pages
Volume 15, Issue 7, Pages 933-937
Issue Date
2011-07-01
Dimensions Badge