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Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam

Phuong NT, Nhung NV, Hoa NB, Thuy HT, Takarinda KC, Tayler-Smith K, Harries AD
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Abstract
SETTING
The programmatic management of drug-resistant tuberculosis (TB) in Viet Nam has been rapidly scaled up since 2009.

OBJECTIVES
To document the annual numbers of patients enrolled for multidrug-resistant tuberculosis (MDR-TB) treatment during 2010-2014 and to determine characteristics and treatment outcomes of patients initiating treatment during 2010-2012.

DESIGN
A retrospective cohort study using national reports and data from the national electronic data system for drug-resistant TB.

RESULTS
The number of patients enrolled annually for MDR-TB treatment increased from 97 in 2010 to 1522 in 2014. The majority of patients were middle-aged men who had pulmonary disease and had failed a retreatment regimen; 77% had received ⩾2 courses of TB treatment. Favourable outcomes (cured and treatment completed) were attained in 73% of patients. Unfavourable outcomes included loss to follow-up (12.5%), death (8%) and failure (6.3%). Having had ⩾2 previous treatment courses and being human immunodeficiency virus-positive were associated with unfavourable outcomes.

CONCLUSION
Increasing numbers of patients are being treated for MDR-TB each year with good treatment outcomes under national programme management in Viet Nam. However, there is a need to increase case detection-currently at 30% of the estimated 5100 MDR-TB cases per year, reduce adverse outcomes and improve monitoring and evaluation.

Countries

Viet Nam

Subject Area

antibiotic resistancetuberculosismodels of careantimicrobial resistance

Languages

English
DOI
10.5588/pha.15.0068
Published Date
21 Mar 2016
PubMed ID
27051608
Journal
Public Health Action
Volume | Issue | Pages
Volume 6, Issue 1, Pages 25-31
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