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Copyright © Médecins Sans Frontières
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Showing 1 - 20 of 20 Items
Showing 1 - 20 of 20 Items
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Journal Article
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Research

Changes over time in the proportion of advanced HIV disease in two high HIV prevalence settings in Ndhiwa (Kenya) and Eshowe (South Africa)

Chihana M, Conan N, Ohler L, Huerga H, Wanjala S,  et al.
2024-06-17 • Journal of the International Association of Providers of AIDS Care
2024-06-17 • Journal of the International Association of Providers of AIDS Care
BACKGROUND
The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...
Journal Article
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Research

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study

Huerga H, Bastard M, Lubega AV, Akinyi M, Antabak NT,  et al.
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...
Journal Article
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Research

Outcomes from the first multidrug-resistant tuberculosis programme in Kenya

Huerga H, Bastard M, Kamene M, Wanjala S, Arnold A,  et al.
2017-03-01 • International Journal of Tuberculosis and Lung Disease
2017-03-01 • International Journal of Tuberculosis and Lung Disease
SETTING
In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya.

OBJECTIVE
To describe patients' treatment outcom...
Journal Article
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Short Report

Culture conversion at six months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

Seung KJ, Khan PY, Franke MF, Ahmed SM, Aiylchiev S,  et al.
2019-11-02 • Clinical Infectious Diseases
2019-11-02 • Clinical Infectious Diseases
Delamanid should be effective against highly resistant strains of Mycobacterium tuberculosis, but uptake has been slow globally. In the endTB (expand new drug markets for TB) Observation...
Journal Article
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Research

Culture conversion at 6 months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

Seung KJ, Khan P, Franke MF, Ahmed S, Aiylchiev S,  et al.
2020-07-11 • Clinical Infectious Diseases
2020-07-11 • Clinical Infectious Diseases

Delamanid should be effective against highly resistant strains of Mycobacteriumtuberculosis, but uptake has been slow globally. In the endTB (expand new drug markets for TB) Observati...

Journal Article
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Research

Voluntary Community Human Immunodeficiency Virus Testing, Linkage, and Retention in Care Interventions in Kenya: Modeling the Clinical Impact and Cost-effectiveness

Luong Nguyen LB, Yazdanpanah Y, Maman D, Wanjala S, Vandenbulcke A,  et al.
2018-05-08 • Clinical Infectious Diseases
2018-05-08 • Clinical Infectious Diseases
In southwest Kenya, the prevalence of human immunodeficiency virus (HIV) infection is about 25%. Médecins Sans Frontières has implemented a voluntary community testing (VCT) program, wit...
Journal Article
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Research

Field Evaluation of Near Point of Care Cepheid GeneXpert HIV-1 Qual for Early Infant Diagnosis

Opollo VS, Nikuze A, Ben Farhat J, Anyango E, Humwa F,  et al.
2018-12-27 • PLOS One
2018-12-27 • PLOS One
Access to point-of-care HIV testing shortens turn-around times, time to diagnosis and reduces loss to follow-up hence minimizing barriers to early linkage to care and treatment among HIV...
Journal Article
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Commentary

Introducing new and repurposed TB drugs: the endTB experience

Seung KJ, Khan UT, Varaine FFV, Ahmed SM, Bastard M,  et al.
2020-10-01 • International Journal of Tuberculosis and Lung Disease
2020-10-01 • International Journal of Tuberculosis and Lung Disease
In 2015, the initiative Expand New Drug Markets for TB (endTB) began, with the objective of reducing barriers to access to the new and repurposed TB drugs. Here we describe the major imp...
Journal Article
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Research

Two-fold increase in the HIV viral load suppression rate along with decreased incidence over six years in Ndhiwa sub-county, Kenya

Conan N, Badawi M, Chihana ML, Wanjala S, Kingwara L,  et al.
2021-10-12 • Tropical Medicine and International Health
2021-10-12 • Tropical Medicine and International Health
BACKGROUND
HIV-positive individuals who maintain an undetectable viral load cannot transmit the virus to others. In 2012, an HIV population-based survey was conducted in Ndhiwa sub-c...
Journal Article
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Short Report

High prevalence of NRTI and NNRTI drug resistance among ART-experienced, hospitalized inpatients

Bossard C, Schramm B, Wanjala S, Jain L, Mucinya G,  et al.
2021-04-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2021-04-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
Journal Article
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Research

Comparative Effectiveness of Interventions to Improve the HIV Continuum of Care and HIV Preexposure Prophylaxis in Kenya: A Model-Based Analysis

Luong Nguyen LB, Freedberg KA, Wanjala S, Maman D, Szumilin E,  et al.
2020-10-27 • Journal of Infectious Diseases
2020-10-27 • Journal of Infectious Diseases
Background
In Western Kenya up to one-quarter of the adult population was human immunodeficiency virus (HIV)-infected in 2012. The Ministry of Health, Médecins Sans Frontières, and ...
Journal Article
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Research

High Proportions of Patients With Advanced HIV Are Antiretroviral Therapy Experienced: Hospitalization Outcomes From 2 Sub-Saharan African Sites

Ousley J, Niyibizi AA, Wanjala S, Vandenbulcke A, Kirubi B,  et al.
2018-03-04 • Clinical Infectious Diseases
2018-03-04 • Clinical Infectious Diseases
Human immunodeficiency virus (HIV) remains an important cause of hospitalization and death in low- and middle- income countries. Yet morbidity and in-hospital mortality patterns remain p...
Technical Report
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Study report

endTB interim analysis report - Bedaquiline- and delaminid- containing regimens achieve excellent interim treatment response without safety concerns

Atwood S, Avagyan N, Bastard M, Cain M, Collin S,  et al.
2018-07-01
2018-07-01
Journal Article
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Research

Cost-effectiveness of diagnostic algorithms including lateral-flow urine lipoarabinomannan for HIV-positive patients with symptoms of tuberculosis

Yakhelef N, Audibert M, Ferlazzo G, Sitienei J, Wanjala S,  et al.
2020-01-30 • PLOS One
2020-01-30 • PLOS One
BACKGROUND
Tuberculosis (TB) is the leading cause of death among HIV-positive patients. We assessed the cost-effectiveness of including lateral-flow urine lipoarabinomannan (LF-LAM) ...
Journal Article
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Research

Impact of "test and treat" recommendations on eligibility for antiretroviral treatment: Cross sectional population survey data from three high HIV prevalence countries

Chihana ML, Huerga H, Van Cutsem G, Ellman T, Wanjala S,  et al.
2018-11-26 • PLOS One
2018-11-26 • PLOS One
Background
Latest WHO guidelines recommend starting HIV-positive individuals on antiretroviral therapy treatment (ART) regardless of CD4 count. We assessed additional impact of adopt...
Journal Article
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Research

Incremental yield of including Determine-TB LAM assay in diagnostic algorithms for hospitalized and ambulatory HIV-positive patients in Kenya

Huerga H, Ferlazzo G, Bevilacqua P, Kirubi B, Ardizzoni E,  et al.
2017-01-26 • PLOS One
2017-01-26 • PLOS One
BACKGROUND
Determine-TB LAM assay is a urine point-of-care test useful for TB diagnosis in HIV-positive patients. We assessed the incremental diagnostic yield of adding LAM to algori...
Journal Article
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Research

Mortality in the first six months among HIV-positive and HIV-negative patients empirically treated for tuberculosis

Huerga H, Ferlazzo G, Wanjala S, Bastard M, Bevilacqua P,  et al.
2019-02-11 • BMC Infectious Diseases
2019-02-11 • BMC Infectious Diseases
Empirical treatment of tuberculosis (TB) may be necessary in patients with negative or no Xpert MTB/RIF results. In a context with access to Xpert, we assessed mortality in the 6 months ...
Journal Article
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Research

Slipping through the cracks: a qualitative study to explore pathways of HIV care and treatment amongst hospitalised patients with advanced HIV in Kenya and the Democratic Republic of the Congo

Burns R, Venables E, Odhoch L, Kocholla L, Wanjala S,  et al.
2021-08-26 • AIDS Care
2021-08-26 • AIDS Care
Advanced HIV causes substantial mortality in sub-Saharan Africa despite widespread antiretroviral therapy coverage. This paper explores pathways of care amongst hospitalised patients wit...
Journal Article
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Research

The HIV cascade of care among serodiscordant couples in four high HIV prevalence settings in sub-Saharan Africa

Chihana ML, Conan N, Ellman T, Poulet E, Garone DB,  et al.
2021-08-02 • South African Medical Journal
2021-08-02 • South African Medical Journal
BACKGROUND
HIV-serodiscordant couples are at high risk of HIV transmission. In sub-Saharan Africa, HIV-serodiscordant couples contribute ~30% of all new infections in the region.
Journal Article
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Research

Distribution of advanced HIV disease from three high HIV prevalence settings in Sub-Saharan Africa: a secondary analysis data from three population-based cross-sectional surveys in Eshowe (South Africa), Ndhiwa (Kenya) and Chiradzulu (Malawi)

Chihana ML, Huerga H, van Cutsem G, Ellman T, Goemaere E,  et al.
2019-01-01 • Global Health Action
2019-01-01 • Global Health Action
BACKGROUND
Despite substantial progress in antiretroviral therapy (ART) scale up, some people living with HIV (PLHIV) continue to present with advanced HIV disease, contributing to o...