logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 20 of 31 Items
Showing 1 - 20 of 31 Items
Sort By: Relevance
  • Newest to oldest
  • Oldest to newest
  • Relevance
Journal Article
|
Research

Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda

Mwanga-Amumpaire J, Adong J, Arinaitwe R, Nanjebe D, Orikiriza P,  et al.
2024-08-27 • BMC Pregnancy and Childbirth
2024-08-27 • BMC Pregnancy and Childbirth

BACKGROUND

Deaths ...

Journal Article
|
Research

Mortality and cause of death in children with presumptive disseminated tuberculosis

Bonnet MMB, Nordholm AC, Ssekyanzi B, Byamukama O, Orikiriza P,  et al.
2023-03-23 • Pediatrics
2023-03-23 • Pediatrics
BACKGROUND AND OBJECTIVES:
Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mor...
Journal Article
|
Research

Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Gunasekera KS, Marcy O, Muñoz J, Lopez-Varela E, Sekadde MP,  et al.
2023-03-13 • Lancet Child and Adolescent Health
2023-03-13 • Lancet Child and Adolescent Health
BACKGROUND
Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm d...
Journal Article
|
Research

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda

Ardizzoni E, Orikiriza P, Ssuuna C, Nyehangane D, Gumsboga M,  et al.
2019-10-16 • Journal of Clinical Microbiology
2019-10-16 • Journal of Clinical Microbiology
Background: Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries. We aimed to assess ...
Journal Article
|
Research

Evaluation of the SD Bioline TB Ag MPT64 test for identification of Mycobacterium tuberculosis complex from liquid cultures in southwestern Uganda

Orikiriza P, Nyehangane D, Atwine D, Kisakye JJ, Kassaza K,  et al.
2017-03-31 • East African Medical Journal
2017-03-31 • East African Medical Journal
BACKGROUND
To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that ...
Journal Article
|
Research

Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda

Oyet C, Roh ME, Kiwanuka G, Orikiriza P, Wade M,  et al.
2017-10-28 • Malaria Journal
2017-10-28 • Malaria Journal
BACKGROUND
Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained sett...
Journal Article
|
Research

Outcome of children with presumptive tuberculosis in Mbarara, rural Uganda

Bonnet MMB, Nansumba M, Bastard M, Orikiriza P, Kyomugasho N,  et al.
2017-08-02 • Pediatric Infectious Disease Journal
2017-08-02 • Pediatric Infectious Disease Journal
BACKGROUND
Mortality among children with presumptive tuberculosis (TB) empiric TB treatment can be high. We describe the predictors of death among children with presumptive TB, and t...
Journal Article
|
Research

Low Resistance to First and Second Line Anti-Tuberculosis Drugs among Treatment Naive Pulmonary Tuberculosis Patients in Southwestern Uganda

Orikiriza P, Tibenderana B, Siedner MJ, Mueller YK, Byarugaba F,  et al.
2015-02-06 • PLOS One
2015-02-06 • PLOS One
There are limited data on region-specific drug susceptibility of tuberculosis (TB) in Uganda. We performed resistance testing on specimens collected from treatment-naive patients with pu...
Journal Article
|
Research

Diagnostic accuracy of the small membrane filtration method for diagnosis of pulmonary tuberculosis in a high HIV prevalence setting

Boum Y II, Kim S, Orikiriza P, Acuña-Villaorduña C, Vinhas S,  et al.
2016-03-30 • Journal of Clinical Microbiology
2016-03-30 • Journal of Clinical Microbiology
Sputum acid-fast bacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB). We prospectively ev...
Journal Article
|
Research

Xpert MTB/RIF diagnosis of childhood tuberculosis from sputum and stool samples in a high TB-HIV-prevalent setting

Orikiriza P, Nansumba M, Nyehangane D, Bastard M, Mugisha IT,  et al.
2018-05-08 • European Journal of Clinical Microbiology and Infectious Diseases
2018-05-08 • European Journal of Clinical Microbiology and Infectious Diseases
The Xpert MTB/RIF assay is a major advance for diagnosis of tuberculosis (TB) in high-burden countries but is limited in children by their difficulty to produce sputum. We investigated T...
Journal Article
|
Research

Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda

Oloya S, Lyczkowski D, Orikiriza P, Irama M, Boum Y II,  et al.
2020-07-02 • BMC Pregnancy and Childbirth
2020-07-02 • BMC Pregnancy and Childbirth
Background
While congenital syphilis is a significant public health problem that can cause severe disabilities, little is known about the situation in Uganda. We describe prevalence...
Journal Article
|
Research

Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children

Orikiriza P, Smith JS, Ssekyanzi B, Nyehangane D, Mugisha IT,  et al.
2021-06-17 • European Respiratory Journal
2021-06-17 • European Respiratory Journal
BACKGROUND
Non-sputum-based diagnostic approaches are crucial in children at high risk of disseminated tuberculosis (TB) who cannot expectorate sputum. We evaluated the diagnostic ac...
Journal Article
|
Research

Intra-gastric string test: an effective tool for diagnosing tuberculosis in adults unable to produce sputum

Atwine D, Nansumba M, Orikiriza P, Riera M, Nackers F,  et al.
2015-05-01 • International Journal of Tuberculosis and Lung Disease
2015-05-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Tuberculosis (TB) diagnosis is challenging in patients who are unable to produce sputum. The string test, a method for retrieving enteropathogens, is a potential alternative ...
Journal Article
|
Research

Lowenstein-Jensen Selective Medium for Reducing Contamination in Mycobacterium tuberculosis Culture

Kassaza K, Orikiriza P, Llosa AE, Bazira J, Nyehangane D,  et al.
2014-07-25 • Journal of Clinical Microbiology
2014-07-25 • Journal of Clinical Microbiology
We compared Mycobacterium tuberculosis sputum culture recovery and contamination rates between Lowenstein-Jensen medium (LJ) containing the following decontaminants and LJ alone: (i) PAN...
Journal Article
|
Research

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

Rao PS, Moore CC, Mbonde AA, Nuwagira E, Orikiriza P,  et al.
2021-06-18 • Antibiotics
2021-06-18 • Antibiotics
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to...
Journal Article
|
Review

A review of antimicrobial resistance in East Africa

Ampaire L, Muhindo A, Orikiriza P, Mwanga-Amumpaire J, Bebell LM,  et al.
2016-09-15 • African Journal of Laboratory Medicine
2016-09-15 • African Journal of Laboratory Medicine
BACKGROUND AND OBJECTIVES
Knowledge of local and regional antimicrobial resistance (AMR) is important for clinical decision making. However, surveillance capacity for AMR is lacking...
Journal Article
|
Research

Detection and Quantification of Mycobacterium Tuberculosis in the Sputum of Culture-Negative HIV-infected Pulmonary Tuberculosis Suspects: A Proof-of-Concept Study

Madico G, Mpeirwe M, White LJ, Vinhas S, Orr B,  et al.
2016-07-08 • PLOS One
2016-07-08 • PLOS One
Rapid diagnosis of pulmonary tuberculosis (TB) is critical for timely initiation of treatment and interruption of transmission. Yet, despite recent advances, many patients remain undiagn...
Journal Article
|
Research

Xpert(®) MTB/RIF for detection of Mycobacterium tuberculosis from frozen string and induced sputum sediments

Atwebembeire J, Orikiriza P, Bonnet MMB, Atwine D, Katawera V,  et al.
2016-08-01 • International Journal of Tuberculosis and Lung Disease
2016-08-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Although it is now widely used for tuberculosis (TB) diagnosis, Xpert® MTB/RIF availability remains inadequate in low-resource settings. Moreover, its accuracy in testing sto...
Journal Article
|
Research

Treatment outcomes and tolerability of the revised WHO anti-tuberculosis drug dosages for children

Nansumba M, Kumbakumba E, Orikiriza P, Bastard M, Mwanga JP,  et al.
2018-02-01 • International Journal of Tuberculosis and Lung Disease
2018-02-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
In 2010, the World Health Organization (WHO) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazi...
Journal Article
|
Research

Detection of Plasmodium species by high resolution melt analysis of DNA from blood smears acquired in Southwestern Uganda

Kassaza K, Operario DJ, Nyehangane D, Coffey KC, Namugosa M,  et al.
2017-10-18 • Journal of Clinical Microbiology
2017-10-18 • Journal of Clinical Microbiology
ABSTRACT

Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited se...