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Showing 1 - 20 of 23 Items
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Review

Clinical best practices for caring for people with expanded resistance to newer TB drugs

Nkomo T, Udwadia Z, Vambe D, van Rie A, Thi S,  et al.
2025-06-13 • IJTLD OPEN
2025-06-13 • IJTLD OPEN

BACKGROUND

Strains of Mycobacterium tuberculosis

Journal Article
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Review
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Research
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Letter
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Review
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Editorial

Drug resistant tuberculosis in Afghanistan: We must continue to put people at the centre of treatment

Mesic A
2022-01-10 • British Medical Journal (BMJ)
2022-01-10 • British Medical Journal (BMJ)
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Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis

Seddon JA, Achar J, Malik AA, Hughes J, Burzynski J,  et al.
2025-06-06 • Lancet Infectious Diseases
2025-06-06 • Lancet Infectious Diseases

Body mass index trajectories and association with tuberculosis risk in a cohort of household contacts in Southern Africa

Larsson L, Calderwood CJ, Marambire ET, Held K, Banze D,  et al.
2025-04-28 • Clinical Infectious Diseases
2025-04-28 • Clinical Infectious Diseases

BACKGROUND

Studies have demonstrated an inverse log-linear relationship between body mass index (BMI) and tuberculosis incidence. However, a person’s BMI is dyn...

Short oral treatment regimens for rifampicin-resistant tuberculosis are safe and effective for young children: results from a field-based non-randomized clinical trial, Kandahar Afghanistan

Mesic A, Decuyper I, Ishaq S, Azizi T, Hadi Ziamal F,  et al.
2024-05-30 • European Respiratory Journal
2024-05-30 • European Respiratory Journal

Systematic review on cumulative HIV viraemia among people living with HIV receiving antiretroviral treatment and its association with mortality and morbidity

Mesic A, Decroo T, Florence E, Ritmeijer KKD, van Olmen J,  et al.
2024-05-01 • International Health
2024-05-01 • International Health
BACKGROUND
We performed a systematic review to generate evidence on the association between cumulative human immunodeficiency virus (HIV) viraemia and health outcomes.

METHO...
In recent years, MSF has been able to improve patients' experiences of care for drug resistant tuberculosis, but the changing political situation threatens to derail this progress, write...

Introducing new and repurposed TB drugs: the endTB experience

Seung KJ, Khan UT, Varaine FFV, Ahmed SM, Bastard M,  et al.
2020-10-01 • International Journal of Tuberculosis and Lung Disease
2020-10-01 • International Journal of Tuberculosis and Lung Disease
In 2015, the initiative Expand New Drug Markets for TB (endTB) began, with the objective of reducing barriers to access to the new and repurposed TB drugs. Here we describe the major imp...

Delivering HIV care in challenging operating environments: the MSF experience towards differentiated models of care for settings with multiple basic health care needs

Ssonko C, Gonzalez L, Mesic A, da Fonseca M, Achar J,  et al.
2017-07-21 • Journal of the International AIDS Society
2017-07-21 • Journal of the International AIDS Society
INTRODUCTION
Countries in the West and Central African regions struggle to offer quality HIV care at scale, despite HIV prevalence being relatively low. In these challenging operatin...

Implications of Differentiated Care for Successful ART Scale-Up in a Concentrated HIV Epidemic in Yangon, Myanmar

Mesic A, Fontaine J, Aye T, Greig J, Thwe TT,  et al.
2017-07-21 • Journal of the International AIDS Society
2017-07-21 • Journal of the International AIDS Society
Introduction: National AIDS Programme in Myanmar has made significant progress in scaling up antiretroviral treatment (ART) services and recognizes the importance of differentiated care ...

Person-centred care and short oral treatment for rifampicin-resistant tuberculosis improve retention in care in Kandahar, Afghanistan

Mesic A, Ishaq S, Khan WH, Mureed A, Mar HT,  et al.
2022-01-03 • Tropical Medicine and International Health
2022-01-03 • Tropical Medicine and International Health
OBJECTIVES
To describe the effect of adaptations to a person-centred care with short oral regimens on retention in care for rifampicin-resistant TB (RR-TB) in Kandahar province, Afgh...

Predictors of virological failure among people living with HIV receiving first line antiretroviral treatment in Myanmar: retrospective cohort analysis

Mesic A, Spina A, Mar HT, Thit P, Decroo T,  et al.
2021-04-21 • AIDS Research and Therapy
2021-04-21 • AIDS Research and Therapy
Abstract
Background
Progress toward the global target for 95% virological supp...

Viraemic-time predicts mortality among people living with HIV on second-line antiretroviral treatment in Myanmar: A retrospective cohort study

Mesic A, Decroo T, Mar HT, Jacobs BKM, Thandar MP,  et al.
2022-07-29 • PLOS One
2022-07-29 • PLOS One
INTRODUCTION
Despite HIV viral load (VL) monitoring being serial, most studies use a cross-sectional design to evaluate the virological status of a cohort. The objective of our study...

Hepatitis C treatment outcomes among people who inject drugs co-infected with HIV in Manipur, India

Himanshu M, Lin Oo W, Cavalheiro AP, Mesic A, Shougrakpam J,  et al.
2020-05-20 • MSF Scientific Days International 2020
2020-05-20 • MSF Scientific Days International 2020

Lessons learned: retrospective assessment of outcomes and management of patients with advanced HIV disease in a semi-urban polyclinic in Epworth, Zimbabwe

Blankley S, Gashu T, Ahmad B, Belaye AK, Ringtho L,  et al.
2019-04-10 • PLOS One
2019-04-10 • PLOS One
INTRODUCTION
HIV continues to be one of the leading causes of infectious death worldwide and presentation with advanced HIV disease is associated with increased morbidity and mortali...

Evaluation of a Chest Radiograph Reading and Recording System for Tuberculosis in a HIV-Positive Cohort

Kosack CS, Spijker S, Halton J, Bonnet MMB, Nicholas S,  et al.
2017-02-21 • Clinical Radiology
2017-02-21 • Clinical Radiology
To assess the impact of introducing a chest radiograph reading and recording system (CRRS) with a short training session, on the accuracy and inter-reader variability of tuberculosis (TB...

Evaluation of second line antiretroviral treatment outcomes and determinants in Epworth, MSF-OCA HIV cohort, Zimbabwe

Zizhou S, Gashu T, Ahmad B, Dhliwayo R, Aluma T,  et al.
2018-07-01
2018-07-01
Summary

Epworth poly-clinic is found in Epworth district, Harare. It is a clinic jointly run by Epworth local board (on behalf of the Ministry of Health and Child Care) and Mé...

Risk factors for mortality during antiretroviral therapy in older populations in resource-limited settings

O'Brien DP, Spelman T, Greig J, McMahon J, Ssonko C,  et al.
2016-01-01 • Journal of the International AIDS Society
2016-01-01 • Journal of the International AIDS Society
INTRODUCTION
An increasing proportion of adult patients initiating antiretroviral therapy (ART) in resource-limited settings are aged >50 years. Older populations on ART appear to ha...

The Impact of a Tick-Sheet in Improving Interpretation Accuracy of Chest Radiographs by Non-Specialists in an HIV positive cohort

Kosack CS, Mesic A, Spijker S, Bonnet MMB, Joekes E
2018-07-01
2018-07-01
Study objective
3.1 Primary objective
To determine if the application of a tick-sheet after four hour training on its use and on CXR
interpretation, improves the interpret...

Modelling the effect of short-course multidrug-resistant tuberculosis treatment in Karakalpakstan, Uzbekistan

Trauer JM, Achar J, Parpieva N, Khamraev AK, Denholm JT,  et al.
2016-11-18 • BMC Medicine
2016-11-18 • BMC Medicine
BACKGROUND
Multidrug-resistant tuberculosis (MDR-TB) is a major threat to global TB control. MDR-TB treatment regimens typically have a high pill burden, last 20 months or more and o...

Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study

Mesic A, Khan WH, Lenglet AD, Lynen L, Ishaq S,  et al.
2020-08-21 • PLOS One
2020-08-21 • PLOS One
INTRODUCTION
Afghanistan is affected by one of the world's longest protracted armed conflicts, frequent natural disasters, disease outbreaks and large population movements and it suf...