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v2.1.5153.produseast1
Showing 1 - 18 of 18 Items
Showing 1 - 18 of 18 Items
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Journal Article
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Research

Risk stratification of childhood infection using host markers of immune and endothelial activation: A multi-country prospective cohort study in Asia (Spot Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • medRxiv
2025-02-05 • medRxiv

BACKGROUND

Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in c...

Journal Article
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Protocol

Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial

Patil SB, Tamirat M, Khazhidinov K, Ardizzoni E, Atger M,  et al.
2023-11-30 • Trials
2023-11-30 • Trials
BACKGROUND
Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yi...
Journal Article
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Research

Concordance of three approaches for operationalizing outcome definitions for multidrug-resistant TB

Zeng C, Mitnick CD, Hewison CCH, Bastard M, Khan PY,  et al.
2023-01-01 • International Journal of Tuberculosis and Lung Disease
2023-01-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
The WHO provides standardized outcome definitions for rifampicin-resistant (RR) and multidrug-resistant (MDR) TB. However, operationalizing these definitions can be challe...
Journal Article
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Short Report

Culture conversion at six months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

Seung KJ, Khan PY, Franke MF, Ahmed SM, Aiylchiev S,  et al.
2019-11-02 • Clinical Infectious Diseases
2019-11-02 • Clinical Infectious Diseases
Delamanid should be effective against highly resistant strains of Mycobacterium tuberculosis, but uptake has been slow globally. In the endTB (expand new drug markets for TB) Observation...
Journal Article
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Research

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Blanc FX, Badje AD, Bonnet MMB, Gabillard D, Messou E,  et al.
2020-06-18 • New England Journal of Medicine
2020-06-18 • New England Journal of Medicine
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...
Conference Material
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Abstract

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Muzoora C
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...
Protocol
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Research Protocol

The endTB observational study protocol: treatment of MDR-TB with bedaquiline or delamanid containing regimens

Khan UT, Huerga H, Khan AS, Mitnick CD, Hewison CCH,  et al.
2019-08-20 • BMC Infectious Diseases
2019-08-20 • BMC Infectious Diseases
BACKGROUND
At a time when programs were struggling to design effective regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB), the marketing authorization of bedaqui...
Journal Article
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Research

Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients

Ahuja SD, Ashkin D, Avendano M, Banerjee R, Bayona J,  et al.
2012-08-28 • PLOS Medicine
2012-08-28 • PLOS Medicine
Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the ...
Journal Article
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Research

Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam

Phuong NT, Nhung NV, Hoa NB, Thuy HT, Takarinda KC,  et al.
2016-03-21 • Public Health Action
2016-03-21 • Public Health Action
SETTING
The programmatic management of drug-resistant tuberculosis (TB) in Viet Nam has been rapidly scaled up since 2009.

OBJECTIVES
To document the annual numbers of p...
Journal Article
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Editorial

QT prolongation for old and new drugs: how much should we really worry?

Motta I, Cozzi SN, Pontali E
2022-04-01 • International Journal of Tuberculosis and Lung Disease
2022-04-01 • International Journal of Tuberculosis and Lung Disease
Journal Article
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Review

Behavioural interventions to address rational use of antibiotics in outpatient settings of low‐income and lower‐middle‐income countries

Nair MM, Mahajan R, Burza S, Zeegers MP
2021-01-16 • Tropical Medicine and International Health
2021-01-16 • Tropical Medicine and International Health
OBJECTIVES
To explore the current evidence on interventions to influence antibiotic prescribing behaviour of health professionals in outpatient settings in low‐income and lower‐middl...
Conference Material
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Video

Promoting patient-centered HIV services with Community Advisory Boards in Vietnam

Linh NN
2021-08-25 • MSF Scientific Days Asia 2021
2021-08-25 • MSF Scientific Days Asia 2021
Journal Article
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Research

Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis

Ford NP, Hargreaves S, Shanks L
2012-08-30 • PLOS One
2012-08-30 • PLOS One
Sepsis is one of the leading causes of childhood mortality, yet controversy surrounds the current treatment approach. We conducted a systematic review to assess the evidence base for flu...
Journal Article
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Research

Detecting tuberculosis: rapid tools but slow progress

England K, Masini T, Fajardo E
2019-09-21 • Public Health Action
2019-09-21 • Public Health Action
The World Health Organization (WHO) currently recommends Xpert® MTB/RIF as the initial test for all people with presumptive tuberculosis (TB). A number of challenges have been reported, ...
Journal Article
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Research

Building leadership capacity and future leaders in operational research in low-income countries: why and how?

Zachariah R, Reid AJ, Srinath S, Chakaya JM, Legins K,  et al.
2011-11-01 • International Journal of Tuberculosis and Lung Disease
2011-11-01 • International Journal of Tuberculosis and Lung Disease
Very limited operational research (OR) emerges from programme settings in low-income countries where the greatest burden of disease lies. The price paid for this void includes a lack of ...
Protocol
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Research Protocol

Prediction of disease severity in young children presenting with acute febrile illness in resource-limited settings: a protocol for a prospective observational study

Chandna A, Aderie EM, Ahmad R, Arguni E, Ashley EA,  et al.
2021-01-25 • BMJ Open
2021-01-25 • BMJ Open
INTRODUCTION
In rural and difficult-to-access settings, early and accurate recognition of febrile children at risk of progressing to serious illness could contribute to improved pati...
Journal Article
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Research

Global programmatic use of bedaquiline and delamanid for the treatment of multidrug-resistant tuberculosis

Cox V, Brigden G, Crespo RH, Lessem E, Lynch S,  et al.
2018-04-01 • International Journal of Tuberculosis and Lung Disease
2018-04-01 • International Journal of Tuberculosis and Lung Disease
SETTING
The World Health Organization recommended two new drugs, bedaquiline (BDQ) and delamanid (DLM), for the treatment of multidrug-resistant tuberculosis (MDR-TB) in 2013 and 201...
Journal Article
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Research

Clonal reconquest of antibiotic-susceptible Salmonella enterica serotype Typhi in Son La Province, Vietnam

Weill FX, Tran HT, Roumagnac P, Fabre L, Minh NB,  et al.
2007-06-01 • American Journal of Tropical Medicine and Hygiene
2007-06-01 • American Journal of Tropical Medicine and Hygiene
In the last three decades, high rates of resistance to common first-line antimicrobial agents have been reported in Salmonella enterica serotype Typhi (Typhi), the causative organism of ...