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Visceral leishmaniasis and HIV coinfection in East Africa | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Visceral leishmaniasis and HIV coinfection in East Africa

Diro EGJ, Lynen L, Ritmeijer KKD, Boelaert M, Hailu ADE, van Griensven J
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Abstract
Visceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload and first in VL-HIV coinfection rate. Because of the alteration in the disease course, the diagnostic challenges, and the poor treatment responses, VL with HIV coinfection has become a very serious challenge in East Africa today. Field experience with the use of liposomal amphotericin B in combination with miltefosine, followed by secondary prophylaxis and antiretroviral drugs, looks promising. However, this needs to be confirmed through clinical trials. Better diagnostic and follow-up methods for relapse and prediction of relapse should also be looked for. Basic research to understand the immunological interaction of the two infections may ultimately help to improve the management of the coinfection.

Countries

Ethiopia Kenya South Sudan Sudan

Subject Area

neglected tropical diseaseskala azarHIV/AIDS

Languages

English
DOI
10.1371/journal.pntd.0002869
Published Date
26 Jun 2014
PubMed ID
24968313
Journal
PLOS Neglected Tropical Diseases
Volume | Issue | Pages
Volume 8, Issue 6, Pages e2869
Issue Date
2014-06-26
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