Navigating considerable risk and uncertainty, including high rates of violence and recent tightening of migration policies, People on the Move (PoM) in Latin America face significant mental health challenges and barriers to care. From 2021 to 2025, Médecins Sans Frontières (MSF) has provided psychological and psychiatric services to PoM in Mexico, Guatemala, Honduras, Costa Rica, and Panama, conducting almost 17,000 consultations since 2024 alone. In our experience, patients face a complex clinical landscape characterized by limited patient-provider interaction time, constantly changing health systems, and inconsistent referral and medication availability, among other challenges. The urgent need to meet basic survival and protection needs often delays attention to mental health. The highly diverse patient population, both from the region and beyond, requires ongoing adaptation to different languages, cultures, and precipitating events and circumstances. In response, MSF adapts a holistic care package including single, brief therapy sessions; group psychoeducation sessions; pediatric recreational activities; cultural mediators; travel kits with psychiatric medication; and trainings for local providers through the Mental Health Gap Action Programme. Additionally, holistic care integrates mental health services with general medical care and social services, while telehealth and digital health promotion enable providers to reach PoM beyond in-person consults. Recent migration policy changes and funding cuts threaten to exacerbate both the mental health of PoM and barriers in service delivery. Ongoing innovation and adaption are essential to support mental health of PoM in a context of evolving and often punitive regional migration policies.