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Journal Article
|Research

High mortality in tuberculosis patients despite HIV interventions in Swaziland

Mchunu G, van Griensven J, Hinderaker SG, Kizito W, Sikhondze W, Manzi M, Dlamini T, Harries AD
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High mortality in tuberculosis patients despite HIV interventions in Swaziland | Journal Article / Research | MSF Science Portal
Abstract
SETTING
All health facilities providing tuberculosis (TB) care in Swaziland.

OBJECTIVE
To describe the impact of human immunodeficiency virus (HIV) interventions on the trend of TB treatment outcomes during 2010-2013 in Swaziland; and to describe the evolution in TB case notification, the uptake of HIV testing, antiretroviral therapy (ART) and cotrimoxazole preventive therapy (CPT), and the proportion of TB-HIV co-infected patients with adverse treatment outcomes, including mortality, loss to follow-up and treatment failure.

DESIGN
A retrospective descriptive study using aggregated national TB programme data.

RESULTS
Between 2010 and 2013, TB case notifications in Swaziland decreased by 40%, HIV testing increased from 86% to 96%, CPT uptake increased from 93% to 99% and ART uptake among TB patients increased from 35% to 75%. The TB-HIV co-infection rate remained around 70% and the proportion of TB-HIV cases with adverse outcomes decreased from 36% to 30%. Mortality remained high, at 14-16%, over the study period, and anti-tuberculosis treatment failure rates were stable over time (<5%).

CONCLUSION
Despite high CPT and ART uptake in TB-HIV patients, mortality remained high. Further studies are required to better define high-risk patient groups, understand the reasons for death and design appropriate interventions.

Countries

Eswatini

Subject Area

tuberculosisSORT-ITHIV/AIDS

Languages

English
DOI
10.5588/pha.15.0081
Published Date
21 Jun 2016
PubMed ID
27358803
Journal
Public Health Action
Volume | Issue | Pages
Volume 6, Issue 2, Pages 105-10
Issue Date
2016-06-21
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