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A four-year nationwide molecular epidemiological study in Estonia: risk factors for tuberculosis transmission | Journal Article / Research | MSF Science Portal
Journal Article
|Research

A four-year nationwide molecular epidemiological study in Estonia: risk factors for tuberculosis transmission

Toit K, Altraja A, Acosta CD, Viiklepp P, Kremer K, Kummik T, Danilovits M, Van der Bergh R, Harries AD, Supply P
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Abstract
SETTING
Estonia has a high proportion of multidrug-resistant tuberculosis (MDR-TB). It is important to link molecular and epidemiological data to understand TB transmission patterns.

OBJECTIVE
To use 24-locus variable numbers of tandem repeat (VNTR) typing and national TB registry data in Estonia from 2009 to 2012 to identify the distribution of drug resistance patterns, Mycobacterium tuberculosis isolate clustering as an index for recent transmission, socio-demographic and clinical characteristics associated with recent transmission, and the distribution of transmission between index and secondary cases.

DESIGN
A retrospective nationwide cross-sectional study.

RESULTS
Of 912 cases with isolate and patient information, 39.1% of isolates were from the Beijing lineage. Cluster analysis identified 87 clusters encompassing 69.1% of isolates. The largest cluster comprised 178 isolates from the Beijing lineage, of which 92.1% were MDR- or extensively drug-resistant TB (XDR-TB). Factors associated with recent transmission were polyresistant TB, MDR- and XDR-TB, human immunodeficiency virus positivity, Russian ethnicity, non-permanent living situation, alcohol abuse and detention. XDR-TB cases had the highest risk of recent transmission. The majority of transmission cases involved individuals aged 30–39 years.

CONCLUSION
Recent TB transmission in Estonia is high and is particularly associated with MDR- and XDR-TB and the Beijing lineage.

Countries

Estonia

Subject Area

tuberculosisSORT-IT

Languages

English
DOI
10.5588/pha.14.0045
Published Date
21 Oct 2014
PubMed ID
26393096
Journal
Public Health Action
Volume | Issue | Pages
Volume 4, Issue 2, Pages S34-S40
Issue Date
2014-10-21
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