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Journal Article > Research

embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation

Plinke C, Cox HS, Zarkua N, Karimovich HA, Braker K, Diel R, Rusch-Gerdes S, Feuerriegel S, Niemann S
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Abstract
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.
Countries
GermanyUzbekistan
Subject Area
tuberculosisgenetics & genomics
DOI
10.1093/jac/dkq120
Published Date
01-Jul-2010
PubMed ID
20427375
Languages
English
Journal
Journal of Antimicrobial Chemotherapy
Volume / Issue / Pages
Volume 65, Issue 7
Issue Date
28-Apr-2010
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