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Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 10 of 10 Items
Showing 1 - 10 of 10 Items
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Journal Article
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Research

Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis

Verrest L, Roseboom IC, Wasunna M, Mbui J, Njenga SN,  et al.
2023-09-20 • Journal of Antimicrobial Chemotherapy
2023-09-20 • Journal of Antimicrobial Chemotherapy
OBJECTIVES
To improve visceral leishmaniasis (VL) treatment in Eastern Africa, 14- and 28-day combination regimens of paromomycin plus allometrically dosed miltefosine were evaluated...
Journal Article
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Commentary

Antibiotic resistance in conflict settings: lessons learned in the Middle East

Kanapathipillai R, Malou N, Hopman J, Bowman C, Yousef N,  et al.
2019-04-10 • Journal of Antimicrobial Chemotherapy
2019-04-10 • Journal of Antimicrobial Chemotherapy
Médecins Sans Frontières (MSF) has designed context-adapted antibiotic resistance (ABR) responses in countries across the Middle East. There, some health systems have been severely damag...
Journal Article
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Research

Increased risk of acquisition and transmission of ESBL-producing Enterobacteriaceae in malnourished children exposed to amoxicillin

Maataoui N, Langendorf C, Berthé F, Bayjanov JR, van Schaik W,  et al.
2020-03-01 • Journal of Antimicrobial Chemotherapy
2020-03-01 • Journal of Antimicrobial Chemotherapy
Objectives
Routine amoxicillin for children with uncomplicated severe acute malnutrition raises concerns of increasing antibiotic resistance. We performed an ancillary study nested ...
Journal Article
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Research

Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis

Cohen K, van Cutsem G, Boulle AM, McIlleron HM, Goemaere E,  et al.
2008-02-01 • Journal of Antimicrobial Chemotherapy
2008-02-01 • Journal of Antimicrobial Chemotherapy
BACKGROUND AND OBJECTIVES: Nevirapine-containing antiretroviral therapy (ART) and rifampicin-based antitubercular therapy are commonly co-administered in Africa, where nevirapine is ofte...
Journal Article
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Research

embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation

Plinke C, Cox HS, Zarkua N, Karimovich HA, Braker K,  et al.
2010-07-01 • Journal of Antimicrobial Chemotherapy
2010-07-01 • Journal of Antimicrobial Chemotherapy
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key rol...
Journal Article
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Research

A comparison of liposomal Amphotericin B with sodium stibogluconate for the treatment of visceral leishmaniasis in pregnancy in Sudan

Mueller M, Balasegaram M, Koummuki Y, Ritmeijer KKD, Santana MR,  et al.
2006-10-01 • Journal of Antimicrobial Chemotherapy
2006-10-01 • Journal of Antimicrobial Chemotherapy
OBJECTIVES: Little is known about the treatment of visceral leishmaniasis (VL) in pregnancy, especially in resource-poor settings. We present a series of pregnant women with VL treated w...
Journal Article
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Research

Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug-drug interaction randomized trial

Atwine D, Baudin E, Gele T, Muyindike WR, Mworozi K,  et al.
2020-01-30 • Journal of Antimicrobial Chemotherapy
2020-01-30 • Journal of Antimicrobial Chemotherapy
Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown.

Objectives: To assess the effect o...
Journal Article
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Research

Nevirapine or efavirenz for tuberculosis and HIV coinfected patients: exposure and virological failure relationship

Bhatt NB, Baudin E, Meggi B, da Silva C, Barrail-Tran A,  et al.
2014-09-18 • Journal of Antimicrobial Chemotherapy
2014-09-18 • Journal of Antimicrobial Chemotherapy
OBJECTIVES
We describe nevirapine and efavirenz exposure on and off tuberculosis treatment and consequences for virological efficacy and tolerance in patients included in the ANRS 12...
Journal Article
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Review

Salmonella enterica serovar Typhi H58 clone has been endemic in Zimbabwe from 2012 to 2019

Mashe T, Leekitcharoenphon P, Mtapuri-Zinyowera S, Kingsley RA, Robertson V,  et al.
2020-12-21 • Journal of Antimicrobial Chemotherapy
2020-12-21 • Journal of Antimicrobial Chemotherapy
BACKGROUND
Typhoid fever, caused by S. enterica ser. Typhi, continues to be a substantial health burden in developing countries. Little is known of the genotypic diversity of S. ente...
Journal Article
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Research

Benznidazole treatment safety: The Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' Disease

Sperandio da Silva G, Felix Mediano M, Hasslocher-Moreno A, Holanda M, Silvestre de Sousa A,  et al.
2017-06-22 • Journal of Antimicrobial Chemotherapy
2017-06-22 • Journal of Antimicrobial Chemotherapy
BACKGROUND
Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment.
...