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Showing 1 - 20 of 44 Items
Showing 1 - 20 of 44 Items
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Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger

Sands K, Lankapalli AK, Lai G, Hassan B, Portal EA,  et al.
2025-08-01 • Nature Communications
2025-08-01 • Nature Communications

Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute...

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The microbiology of noma: insights from a pilot deep shotgun metagenomic project of patients presenting at the Noma Children’s Hospital, Sokoto, Nigeria

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The microbiology of noma: insights from a pilot deep shotgun metagenomic project of patients presenting at the Noma Children’s Hospital, Sokoto, Nigeria

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Olaleye M, O'Ferrell AM, Goodman R, Kabila DW, Peters M,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
Olaleye M, O'Ferrell AM, Goodman R, Kabila DW, Peters M,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025

Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis—experiences from Armenia

Ardizzoni E, Mulders W, De Diego Fuertes M, Hayrapetyan A, Mirzoyan A,  et al.
2025-04-09 • Antimicrobial Agents and Chemotherapy
2025-04-09 • Antimicrobial Agents and Chemotherapy

Risk factors for baseline bedaquiline (BDQ) resistance, amplification during treatment, and correlations with treatment outcomes are not fully understood. This cohort included Armenia...

Initial detection of SARS-CoV-2 Omicron BA.4 and BA.5 subvariants associated with the onset of the fifth wave of COVID-19 in Cameroon between December 2021 and June 2022: Phylogenetic and whole genome analysis

Otshudiema J, Essomba R, Diagne M, Bitoungui V, Ebogo Y,  et al.
2025-01-24 • Medical Research Archives
2025-01-24 • Medical Research Archives

BACKGROUND

Two sub variants (BA.4 and BA.5) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant are concerning as they are sprea...

The genetic diversity of Nipah virus across spatial scales

Cortes-Azuero O, Lefrancq N, Nikolay B, McKee C, Cappelle J,  et al.
2024-12-16 • Journal of Infectious Diseases
2024-12-16 • Journal of Infectious Diseases

BACKGROUND

Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats m...

Eastern Visayas Birth Cohort (EVBC) study protocol: Unraveling the integrative omics and nutritional determinants of child development from prenatal to early childhood

Nacis JS, Serafico ME, Frane RD, Domalanta-Ronquillo DGA, Licayan JJSL,  et al.
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024

Genetic diversity and allelic variability of pfmsp1 y pfmsp2 of P. falciparum and its association with syntomatology and antimalarial drugs resistance markers in Yambio county, South Sudan

Fuente IMdl, Benito MJS, Gisbert FB, García L, González V,  et al.
2024-02-21 • Malaria Journal
2024-02-21 • Malaria Journal
BACKGROUND
Malaria genetic diversity is an important indicator of malaria transmission. Pfmsp1 and pfmsp2 are a frequent molecular epidemiology tool to assess the genetic diversity. ...

HLA-A*03:01 is associated with visceral leishmaniasis development in people living with HIV in Ethiopia

de Vrij N, Vandoren R, Ramadan K, Van Hul A, Kassa M,  et al.
2024-02-18 • medRxiv
2024-02-18 • medRxiv
Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. VL-H...

Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon

Fokam J, Essomba RG, Njouom R, Okomo MCA, Eyangoh S,  et al.
2023-12-08 • Scientific Reports
2023-12-08 • Scientific Reports
While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2...

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F,  et al.
2023-10-19 • Lancet Microbe
2023-10-19 • Lancet Microbe
BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...

Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel

Acford-Palmer H, Campos M, Bandibabone JB, N’Do S, Bantuzeko C,  et al.
2023-10-13 • Scientific Reports
2023-10-13 • Scientific Reports
Vector control strategies have been successful in reducing the number of malaria cases and deaths globally, but the spread of insecticide resistance represents a significant threat to di...

Faecal carriage of extended-spectrum ß-lactamase-producing Escherichia coli in a remote region of Niger

Jacquier H, Assao B, Chau F, Guindo O, Condamine B,  et al.
2023-06-25 • Journal of Infection
2023-06-25 • Journal of Infection
OBJECTIVE
Whole genome sequencing (WGS) of extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-E. coli) in developing countries is lacking. Here we describe the population...

Operationalising targeted next-generation sequencing for routine diagnosis of drug-resistant TB

Iyer AS, Ndlovu Z, Sharma J, Mansoor H, Bharati M,  et al.
2023-06-21 • Public Health Action
2023-06-21 • Public Health Action
BACKGROUND
Phenotypic drug susceptibility testing (pDST) for Mycobacterium tuberculosis can take up to 8 weeks, while conventional molecular tests identify a limited set of resistanc...

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

Goig GA, Menardo F, Salaam-Dreyer Z, Dippenaar A, Streicher EM,  et al.
2023-06-06 • Lancet Microbe
2023-06-06 • Lancet Microbe
BACKGROUND
Experimental data show that drug-resistance-conferring mutations are often associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitnes...

Whole-genome sequencing for surveillance of antimicrobial resistance in Ecuador: present and future implications

Calero-Cáceres W, Ortuño-Gutiérrez N, Sunyoto T, Gomes-Dias CA, Bastidas-Caldes C,  et al.
2023-04-19 • Revista panamericana de salud publica (Pan American Journal of Public Health)
2023-04-19 • Revista panamericana de salud publica (Pan American Journal of Public Health)
Whole-genome sequencing is becoming the gold standard for pathogen characterization and offers considerable advantages for understanding the evolution and dissemination of new determinan...

Clinical utility of target-based next-generation sequencing for drug-resistant TB

Mansoor H, Hirani N, Chavan VV, Das M, Sharma J,  et al.
2023-01-01 • International Journal of Tuberculosis and Lung Disease
2023-01-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
In high TB burden countries, access to drug susceptibility testing is a major bottleneck. Targeted next-generation sequencing (tNGS) is a promising technology for rapid re...

Genomic microevolution of Vibrio cholerae O1, Lake Tanganyika Basin, Africa

Hounmanou YM, Njamkepo E, Rauzier J, Gallandat K, Jeandron A,  et al.
2023-01-01 • Emerging Infectious Diseases
2023-01-01 • Emerging Infectious Diseases
Africa’s Lake Tanganyika basin is a cholera hotspot. During 2001–2020, Vibrio cholerae O1 isolates obtained from the Democratic Republic of the Congo side of the lake belonged to 2 of th...

Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017

Nouhin J, Iwamoto M, Prak S, Doussett JP, Phon K,  et al.
2019-05-13 • Scientific Reports
2019-05-13 • Scientific Reports
In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we perfor...

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Nicand E, Armstrong GL, Enouf V, Guthmann JP, Guerin JP,  et al.
2005-12-01 • Journal of Medical Virology
2005-12-01 • Journal of Medical Virology
The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced...