Search Results | MSF Science Portal

Journal Article

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Research

Ardizzoni E, Mulders W, De Diego Fuertes M, Hayrapetyan A, Mirzoyan A, et al.

2025-04-09 • Antimicrobial Agents and Chemotherapy

Risk factors for baseline bedaquiline (BDQ) resistance, amplification during treatment, and correlations with treatment outcomes are not fully understood. This cohort included Armenia...

Journal Article

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Research

Otshudiema J, Essomba R, Diagne M, Bitoungui V, Ebogo Y, et al.

2025-01-24 • Medical Research Archives

BACKGROUND

Two sub variants (BA.4 and BA.5) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant are concerning as they are sprea...

Journal Article

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Research

Cortes-Azuero O, Lefrancq N, Nikolay B, McKee C, Cappelle J, et al.

2024-12-16 • Journal of Infectious Diseases

BACKGROUND

Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats m...

Conference Material

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Poster

Nacis JS, Serafico ME, Frane RD, Domalanta-Ronquillo DGA, Licayan JJSL, et al.

2024-05-03 • MSF Paediatric Days 2024

Journal Article

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Pre-Print

Fuente IMdl, Benito MJS, Gisbert FB, García L, González V, et al.

2024-02-21 • Malaria Journal

BACKGROUND
Malaria genetic diversity is an important indicator of malaria transmission. Pfmsp1 and pfmsp2 are a frequent molecular epidemiology tool to assess the genetic diversity. ...

Journal Article

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Pre-Print

de Vrij N, Vandoren R, Ramadan K, Van Hul A, Kassa M, et al.

2024-02-18 • medRxiv

Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. VL-H...

Journal Article

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Research

Fokam J, Essomba RG, Njouom R, Okomo MCA, Eyangoh S, et al.

2023-12-08 • Scientific Reports

While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2...

Journal Article

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Research

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F, et al.

2023-10-19 • Lancet Microbe

BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...

Journal Article

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Research

Acford-Palmer H, Campos M, Bandibabone JB, N’Do S, Bantuzeko C, et al.

2023-10-13 • Scientific Reports

Vector control strategies have been successful in reducing the number of malaria cases and deaths globally, but the spread of insecticide resistance represents a significant threat to di...

Journal Article

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Research

Jacquier H, Assao B, Chau F, Guindo O, Condamine B, et al.

2023-06-25 • Journal of Infection

OBJECTIVE
Whole genome sequencing (WGS) of extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-E. coli) in developing countries is lacking. Here we describe the population...

Journal Article

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Research

Iyer AS, Ndlovu Z, Sharma J, Mansoor H, Bharati M, et al.

2023-06-21 • Public Health Action

BACKGROUND
Phenotypic drug susceptibility testing (pDST) for Mycobacterium tuberculosis can take up to 8 weeks, while conventional molecular tests identify a limited set of resistanc...

Journal Article

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Research

Goig GA, Menardo F, Salaam-Dreyer Z, Dippenaar A, Streicher EM, et al.

2023-06-06 • Lancet Microbe

BACKGROUND
Experimental data show that drug-resistance-conferring mutations are often associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitnes...

Journal Article

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Commentary

Calero-Cáceres W, Ortuño-Gutiérrez N, Sunyoto T, Gomes-Dias CA, Bastidas-Caldes C, et al.

2023-04-19 • Revista panamericana de salud publica (Pan American Journal of Public Health)

Whole-genome sequencing is becoming the gold standard for pathogen characterization and offers considerable advantages for understanding the evolution and dissemination of new determinan...

Journal Article

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Research

Mansoor H, Hirani N, Chavan VV, Das M, Sharma J, et al.

2023-01-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
In high TB burden countries, access to drug susceptibility testing is a major bottleneck. Targeted next-generation sequencing (tNGS) is a promising technology for rapid re...

Journal Article

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Research

Hounmanou YM, Njamkepo E, Rauzier J, Gallandat K, Jeandron A, et al.

2023-01-01 • Emerging Infectious Diseases

Africa’s Lake Tanganyika basin is a cholera hotspot. During 2001–2020, Vibrio cholerae O1 isolates obtained from the Democratic Republic of the Congo side of the lake belonged to 2 of th...

Journal Article

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Letter

Memani B, Furin J, Cox HS, Reuter A

2022-12-01 • International Journal of Tuberculosis and Lung Disease

Journal Article

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Research

Nouhin J, Iwamoto M, Prak S, Doussett JP, Phon K, et al.

2019-05-13 • Scientific Reports

In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we perfor...

Journal Article

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Research

Nicand E, Armstrong GL, Enouf V, Guthmann JP, Guerin JP, et al.

2005-12-01 • Journal of Medical Virology

The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced...

Journal Article

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Research

Ismail N, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.

2021-11-12 • Lancet Infectious Diseases

BACKGROUND
Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did...

Journal Article

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Research

Feuerriegel S, Cox HS, Zarkua N, Karimovich HA, Braker K, et al.

2009-05-26 • Antimicrobial Agents and Chemotherapy

The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is crucial for the institution of appropriate treatment regimens as early as possible. Although ...

Science Portal

Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis—experiences from Armenia

Initial detection of SARS-CoV-2 Omicron BA.4 and BA.5 subvariants associated with the onset of the fifth wave of COVID-19 in Cameroon between December 2021 and June 2022: Phylogenetic and whole genome analysis

The genetic diversity of Nipah virus across spatial scales

Eastern Visayas Birth Cohort (EVBC) study protocol: Unraveling the integrative omics and nutritional determinants of child development from prenatal to early childhood

Genetic diversity and allelic variability of pfmsp1 y pfmsp2 of P. falciparum and its association with syntomatology and antimalarial drugs resistance markers in Yambio county, South Sudan

HLA-A*03:01 is associated with visceral leishmaniasis development in people living with HIV in Ethiopia

Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel

Faecal carriage of extended-spectrum ß-lactamase-producing Escherichia coli in a remote region of Niger

Operationalising targeted next-generation sequencing for routine diagnosis of drug-resistant TB

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

Whole-genome sequencing for surveillance of antimicrobial resistance in Ecuador: present and future implications

Clinical utility of target-based next-generation sequencing for drug-resistant TB

Genomic microevolution of Vibrio cholerae O1, Lake Tanganyika Basin, Africa

A very sneaky bug: perspectives of front-line clinicians on whole-genome sequencing for drug-resistant TB

Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal study

Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment