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Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine

Graupner J, Göbels K, Grobusch MP, Lund A, Richter J, Häussinger D
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Abstract
Falciparum malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (+/-1.9) and more pronounced in children with anaemia<10 g/dl on enrollment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.

Countries

Nigeria

Subject Area

malariaantimicrobial resistanceantimalarial drug efficacy

Languages

English
DOI
10.1007/s00436-005-1325-7
Published Date
28 Apr 2005
PubMed ID
15864651
Journal
Parasitology Research
Volume | Issue | Pages
Volume 96, Issue 3, Pages 162-165
Issue Date
2005-04-28
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