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endTB: finding shorter, less toxic, and more effective treatments for MDR-TB

endTB: finding shorter, less toxic, and more effective treatments for MDR-TB

The endTB project aims to find shorter, less toxic and more effective treatments for ‘multidrug-resistant TB’ (MDR-TB) through: 1) access to new drugs, 2) two clinical trials, and 3) advocacy at national and global levels.

The groundbreaking endTB clinical trial results were just published, where a personalized medicine approach highlights the benefits of a new shorter treatment strategy for extensively drug-resistant tuberculosis.

Read the new publication and over 40 research resources, publications, and protocol documents from the endTB project.

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Noma, a neglected disease

Noma, a neglected disease

Noma, also known as cancrum oris, is a rapidly progressing life-threatening infection that affects the mouth and face. Noma is preventable and easy to treat if addressed in the early reversible stages, but most often deadly if untreated. The disease most commonly affects children who are chronically malnourished or whose immune systems are otherwise compromised. Noma affects an estimated 140,000 children annually. Noma was added to the WHO's list of Neglected Tropical Diseases in 2023. 


MSF is working to discover more about noma. This collection highlights MSF's mixed methods research on treatment outcomes, burden of disease, attitudes towards the disease and other aspects of noma.

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Safe abortion care at MSF

Safe abortion care at MSF

Unsafe abortion is one of the main causes of maternal death, and the only one that is completely preventable. Yet over 30 million unsafe abortions occur each year, leading to at least 28,000 deaths and millions of serious complications—nearly all in low- and middle-income countries. MSF teams see these tragic consequences first-hand, treating thousands of patients every year with severe, potentially life-threatening effects from unsafe abortion.

To mark International Safe Abortion Awareness Day (28 September 2023) this Collection presents highlights of MSF’s work on providing SAC as a way to reduce maternal death and injury. By re-assessing and reshaping how our projects deliver SAC in fragile and conflict-affected settings, we have been able to significantly expand services not only in those contexts but across MSF projects globally. In parallel we also conducted in-depth studies of abortion-related dynamics in several complex settings, especially among women who experienced severe complications. Collectively these findings are helping to identify gaps in service delivery and inform operational decision-making. And in a shift accelerated by the Covid-19 pandemic, we are increasingly working towards and advocating for more community-led, self-managed SAC.

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Find MSF Ethics Review Board documents here, and other MSF research and publication guidance documents here.


Featured Content

Editor’s Picks

Journal Article > Letter
British Medical Journal (BMJ)

Environmental changes in South Sudan are changing the fabric of people’s lives and steering humanitarian operations

23-Oct-2024
Journal Article > Research
Reproductive Health

Assessing post-abortion care using the WHO quality of care framework for maternal and newborn health: a cross-sectional study in two African hospitals in humanitarian settings

05-Aug-2024
Journal Article > Commentary
Lancet Global Health

The role of humanitarian actors in global governance for AMR

01-Jul-2024
Technical Report > Evidence Brief

Prevalence of active HCV infection and associated risk factors among members of Forcibly Displaced Myanmar National (FDMN) Population residing in camps, Cox’s Bazar, Bangladesh

01-Nov-2023
Journal Article > Research
PLOS Global Public Health

High caseload of Scabies amongst Rohingya refugees in Cox’s Bazar, Bangladesh: a retrospective analysis of the epidemiological and clinical characteristics of cases, July 2022 to November 2023

09-Apr-2025
Journal Article > Research
Lancet Global Health

24-week, all-oral regimens for pulmonary rifampicin-resistant tuberculosis in TB-PRACTECAL trial sites: an economic evaluation

01-Feb-2025
Journal Article > Research
New England Journal of Medicine

Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis

29-Jan-2025
Conference Material > Abstract
International Papillomavirus 2024

Scaling up cervical cancer screening in Southern Malawi: Screening models for difficult-to-reach populations

12-Nov-2024
Conference Material > Slide Presentation
MSF Scientific Days Asia 2024

Transforming MSF’s approach to community-led initiatives

08-Nov-2024
Technical Report > Policy Brief

Joint brief: The Lancet Countdown on Health and Climate Change & Médecins Sans Frontières

29-Oct-2024
Journal Article > Letter
British Medical Journal (BMJ)

Environmental changes in South Sudan are changing the fabric of people’s lives and steering humanitarian operations

23-Oct-2024
Journal Article > Research
Reproductive Health

Assessing post-abortion care using the WHO quality of care framework for maternal and newborn health: a cross-sectional study in two African hospitals in humanitarian settings

05-Aug-2024
Journal Article > Commentary
Lancet Global Health

The role of humanitarian actors in global governance for AMR

01-Jul-2024
Technical Report > Evidence Brief

Prevalence of active HCV infection and associated risk factors among members of Forcibly Displaced Myanmar National (FDMN) Population residing in camps, Cox’s Bazar, Bangladesh

01-Nov-2023
Journal Article > Research
PLOS Global Public Health

High caseload of Scabies amongst Rohingya refugees in Cox’s Bazar, Bangladesh: a retrospective analysis of the epidemiological and clinical characteristics of cases, July 2022 to November 2023

09-Apr-2025
Journal Article > Research
Lancet Global Health

24-week, all-oral regimens for pulmonary rifampicin-resistant tuberculosis in TB-PRACTECAL trial sites: an economic evaluation

01-Feb-2025
Journal Article > Research
New England Journal of Medicine

Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis

29-Jan-2025
Conference Material > Abstract
International Papillomavirus 2024

Scaling up cervical cancer screening in Southern Malawi: Screening models for difficult-to-reach populations

12-Nov-2024
Conference Material > Slide Presentation
MSF Scientific Days Asia 2024

Transforming MSF’s approach to community-led initiatives

08-Nov-2024
Technical Report > Policy Brief

Joint brief: The Lancet Countdown on Health and Climate Change & Médecins Sans Frontières

29-Oct-2024
Journal Article > Letter
British Medical Journal (BMJ)

Environmental changes in South Sudan are changing the fabric of people’s lives and steering humanitarian operations

23-Oct-2024
Journal Article > Research
Reproductive Health

Assessing post-abortion care using the WHO quality of care framework for maternal and newborn health: a cross-sectional study in two African hospitals in humanitarian settings

05-Aug-2024
Journal Article > Commentary
Lancet Global Health

The role of humanitarian actors in global governance for AMR

01-Jul-2024
Technical Report > Evidence Brief

Prevalence of active HCV infection and associated risk factors among members of Forcibly Displaced Myanmar National (FDMN) Population residing in camps, Cox’s Bazar, Bangladesh

01-Nov-2023

Newest Content

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Journal Article > Research
PLOS Global Public Health
Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens
23-Apr-2025
Journal Article > Research
PLOS Global Public Health
COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa
23-Apr-2025
Journal Article > Short Report
PLOS Neglected Tropical Diseases
Defining the noma research agenda
21-Apr-2025
Journal Article > Research
BMC Infectious Diseases
Mycoplasma genitalium infection in Eswatini amid syndromic case management: Prevalence, coinfections, diagnostic challenges and treatment gaps
17-Apr-2025
Journal Article > Research
PLOS Global Public Health
Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo
02-May-2025
Journal Article > Review
Lancet HIV
Lateral flow assay-based CD4 cell count testing for advanced HIV disease
01-May-2025
Journal Article > Research
Clinical Infectious Diseases
Body mass index trajectories and association with tuberculosis risk in a cohort of household contacts in Southern Africa
28-Apr-2025
Journal Article > Research
Scientific Reports
Enhancing tuberculosis (TB) case detection among hospitalized patients through lay health worker led screening: a before-and-after study in KwaZulu-Natal, South Africa
23-Apr-2025
Journal Article > Research
PLOS Global Public Health
Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens
23-Apr-2025
Journal Article > Research
PLOS Global Public Health
COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa
23-Apr-2025
Journal Article > Short Report
PLOS Neglected Tropical Diseases
Defining the noma research agenda
21-Apr-2025
Journal Article > Research
BMC Infectious Diseases
Mycoplasma genitalium infection in Eswatini amid syndromic case management: Prevalence, coinfections, diagnostic challenges and treatment gaps
17-Apr-2025
Journal Article > Research
PLOS Global Public Health
Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo
02-May-2025
Journal Article > Review
Lancet HIV
Lateral flow assay-based CD4 cell count testing for advanced HIV disease
01-May-2025
Journal Article > Research
Clinical Infectious Diseases
Body mass index trajectories and association with tuberculosis risk in a cohort of household contacts in Southern Africa
28-Apr-2025
Journal Article > Research
Scientific Reports
Enhancing tuberculosis (TB) case detection among hospitalized patients through lay health worker led screening: a before-and-after study in KwaZulu-Natal, South Africa
23-Apr-2025
Journal Article > Research
PLOS Global Public Health
Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens
23-Apr-2025
Journal Article > Research
PLOS Global Public Health
COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa
23-Apr-2025
Journal Article > Short Report
PLOS Neglected Tropical Diseases
Defining the noma research agenda
21-Apr-2025
Journal Article > Research
BMC Infectious Diseases
Mycoplasma genitalium infection in Eswatini amid syndromic case management: Prevalence, coinfections, diagnostic challenges and treatment gaps
17-Apr-2025
>