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Showing 1 - 20 of 23 Items
Showing 1 - 20 of 23 Items
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Journal Article
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Research

Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar

Guthmann JP, Pittet A, Lesage A, Imwong M, Lindegardh N,  et al.
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar. METHODS: Enrolled patients at Sonsinphya clinic >6 m...
Journal Article
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Research

Population pharmacokinetics of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

Kloprogge F, Piola P, Dhorda M, Muwanga S, Turyakira E,  et al.
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and...
Journal Article
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Research

Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Ashley EA, Touabi M, Ahrer M, Hutagalung R, Htun K,  et al.
2009-10-27 • Malaria Journal
2009-10-27 • Malaria Journal
BACKGROUND: In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the...
Journal Article
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Research

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C,  et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Journal Article
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Research

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B,  et al.
2012-05-03 • Malaria Journal
2012-05-03 • Malaria Journal
BACKGROUND
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, rando...
Journal Article
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Research

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

Taylor WRJ, Hoglund RM, Peerawaranun P, Nguyen TN, Hien TT,  et al.
2021-09-09 • Malaria Journal
2021-09-09 • Malaria Journal
BACKGROUND
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed tar...
Journal Article
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Research

Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria

Mytton OT, Ashley EA, Peto L, Price RN, La Y,  et al.
2007-09-01 • American Journal of Tropical Medicine and Hygiene
2007-09-01 • American Journal of Tropical Medicine and Hygiene
Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical tri...
Journal Article
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Research

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JH,  et al.
2007-04-01 • Journal of Infectious Diseases
2007-04-01 • Journal of Infectious Diseases
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudesce...
Journal Article
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Research

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Kloprogge F, Workman L, Borrmann S, Tekete M, Lefevre G,  et al.
2018-06-12 • PLOS Medicine
2018-06-12 • PLOS Medicine
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine...
Journal Article
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Research

Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites

Anderson TJC, Nair SA, Sudimack D, Williams JT, Mayxay M,  et al.
2005-12-01 • Molecular Biology and Evolution
2005-12-01 • Molecular Biology and Evolution
Loci targeted by directional selection are expected to show elevated geographical population structure relative to neutral loci, and a flurry of recent papers have used this rationale to...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Journal Article
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Research

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis

Pfeffer DA, Ley B, Howes RE, Adu P, Alam MS,  et al.
2020-05-14 • PLOS Medicine
2020-05-14 • PLOS Medicine

BACKGROUND

The...

Journal Article
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Research

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial

Piola P, Nabasumba C, Turyakira E, Dhorda M, Lindegardh N,  et al.
2010-11-01 • Lancet Infectious Diseases
2010-11-01 • Lancet Infectious Diseases
BACKGROUND: Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second...
Journal Article
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Research

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...
Journal Article
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Research

Selection strength and hitchhiking around two anti-malarial resistance genes

Nash D, Nair SA, Mayxay M, Newton PN, Guthmann JP,  et al.
2005-06-02 • Proceedings. Biological sciences / The Royal Society
2005-06-02 • Proceedings. Biological sciences / The Royal Society
Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is though...
Journal Article
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Research

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis

Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis FM,  et al.
2009-07-29 • PLOS One
2009-07-29 • PLOS One
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patien...
Journal Article
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Research

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine and quinine in pregnant women with uncomplicated falciparum malaria in Uganda

Tarning J, Kloprogge F, Dhorda M, Jullien V, Nosten F,  et al.
2013-08-05 • Antimicrobial Agents and Chemotherapy
2013-08-05 • Antimicrobial Agents and Chemotherapy
ABSTRACTPregnancy alters the pharmacokinetic properties of many drugs used in the treatment of malaria, usually resulting in lower drug exposures. This i...
Journal Article
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Research

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L,  et al.
2008-03-01 • Antimicrobial Agents and Chemotherapy
2008-03-01 • Antimicrobial Agents and Chemotherapy
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-pi...
Journal Article
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Research

Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development

Guerin PJ, Olliaro PL, Nosten F, Druilhe P, Laxminarayan R,  et al.
2002-09-01 • Lancet Infectious Diseases
2002-09-01 • Lancet Infectious Diseases
Rolling back malaria is possible. Tools are available but they are not used. Several countries deploy, as their national malaria control treatment policy, drugs that are no longer effect...
Journal Article
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Research

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant plasmodium falciparum distributions in Southeast Asia

Grist EP, Fleqq JA, Humphreys G, Mas IS, Anderson TJC,  et al.
2016-10-24 • International Journal of Health Geographics
2016-10-24 • International Journal of Health Geographics
BACKGROUND
Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their...