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Showing 1 - 13 of 13 Items
Showing 1 - 13 of 13 Items
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Journal Article
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Research

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R,  et al.
2025-02-01 • Lancet Child and Adolescent Health
2025-02-01 • Lancet Child and Adolescent Health

BACKGROUND

There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially ...

Journal Article
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Letter

Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis

Cox HS, Sibilia C, Feuerriegel S, Kalon S, Polonsky JA,  et al.
2008-11-27 • New England Journal of Medicine
2008-11-27 • New England Journal of Medicine
Journal Article
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Research

The Epidemiology, Pathogenesis, Transmission, Diagnosis, and Management of Multidrug-Resistant, Extensively Drug-Resistant, and Incurable Tuberculosis

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R,  et al.
2017-03-15 • Lancet Respiratory Medicine
2017-03-15 • Lancet Respiratory Medicine
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tube...
Journal Article
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Research

Tuberculosis recurrence and mortality after successful treatment: impact of drug resistance

Cox HS, Kebede YYK, Allamuratova S, Ismailov G, Davletmuratova Z,  et al.
2006-10-01 • PLOS Medicine
2006-10-01 • PLOS Medicine
BACKGROUND: The DOTS (directly observed treatment short-course) strategy for tuberculosis (TB) control is recommended by the World Health Organization globally. However, there are few st...
Journal Article
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Research

MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era

Beckert P, Sanchez-Padilla E, Merker M, Dreyer V, Kohl TA,  et al.
2020-11-25 • Genome Medicine
2020-11-25 • Genome Medicine
Background
Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F ...
Journal Article
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Research

Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment

Feuerriegel S, Cox HS, Zarkua N, Karimovich HA, Braker K,  et al.
2009-05-26 • Antimicrobial Agents and Chemotherapy
2009-05-26 • Antimicrobial Agents and Chemotherapy
The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is crucial for the institution of appropriate treatment regimens as early as possible. Although ...
Journal Article
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Research

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q,  et al.
2016-10-31 • Nature Genetics
2016-10-31 • Nature Genetics
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collectio...
Journal Article
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Research

Whole genome sequencing reveals complex evolution patterns of multidrug-resistant mycobacterium tuberculosis Beijing strains in patients

Merker M, Kohl TA, Roetzer A, Truebe L, Richter E,  et al.
2013-12-06 • PLOS One
2013-12-06 • PLOS One
Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains represent a major threat for tuberculosis (TB) control. Treatment of MDR-TB patients is long and less effectiv...
Journal Article
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Research

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Merker M, Blin C, Mona S, Duforet-Frebourg N, Lecher S,  et al.
2015-01-19 • Nature Genetics
2015-01-19 • Nature Genetics
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here w...
Journal Article
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Research

embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation

Plinke C, Cox HS, Zarkua N, Karimovich HA, Braker K,  et al.
2010-07-01 • Journal of Antimicrobial Chemotherapy
2010-07-01 • Journal of Antimicrobial Chemotherapy
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key rol...
Journal Article
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Letter

Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland

Sanchez-Padilla E, Merker M, Jochims F, Dlamini T, Kahn P,  et al.
2015-03-19 • New England Journal of Medicine
2015-03-19 • New England Journal of Medicine
Journal Article
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Research

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection

Bonnet MMB, Pardini M, Meacci F, Orru G, Yesilkaya H,  et al.
2011-08-23 • PLOS One
2011-08-23 • PLOS One
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibil...
Journal Article
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Research

Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance

Cox HS, Niemann S, Ismailov G, Doshetov D, Orozco JD ,  et al.
2007-06-01 • Clinical Infectious Diseases
2007-06-01 • Clinical Infectious Diseases
BACKGROUND: Data on the performance of standardized short-course directly observed treatment (DOTS) of tuberculosis (TB) in areas with high levels of drug resistance and on the potential...