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Showing 1 - 20 of 22 Items
Showing 1 - 20 of 22 Items
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Journal Article
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Review

Lateral flow assay-based CD4 cell count testing for advanced HIV disease

Ndlovu Z, Moore A, Casas EC, Fatti G
2025-05-01 • Lancet HIV
2025-05-01 • Lancet HIV
Journal Article
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Research

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

Journal Article
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Commentary

From equitable access to equitable innovation: rethinking bioengineering for global health

Street A, Kersaudy Kerhoas M, Ndlovu Z
2024-04-02 • Nature Reviews Bioengineering
2024-04-02 • Nature Reviews Bioengineering

What does global health equity mean? In bioengineering, ‘equity’ is often interpreted as global ‘access’ to technologies, thereby neglecting wider structural inequalities. Here we sug...

Journal Article
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Research

Operationalising targeted next-generation sequencing for routine diagnosis of drug-resistant TB

Iyer AS, Ndlovu Z, Sharma J, Mansoor H, Bharati M,  et al.
2023-06-21 • Public Health Action
2023-06-21 • Public Health Action
BACKGROUND
Phenotypic drug susceptibility testing (pDST) for Mycobacterium tuberculosis can take up to 8 weeks, while conventional molecular tests identify a limited set of resistanc...
Conference Material
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Slide Presentation

High prevalence of bedaquiline and linezolid resistance in extensively drug-resistant tuberculosis patients in a Médecins Sans Frontières clinic, Mumbai, India

Khan S, Silsarma A, Iyer AS, Galindo MA, Chavan VV,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
Conference Material
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Abstract

High prevalence of bedaquiline and linezolid resistance in extensively drug-resistant tuberculosis patients in a Médecins Sans Frontières clinic, Mumbai, India

Khan S, Silsarma A, Iyer AS, Galindo MA, Chavan VV,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
INTRODUCTION
Bedaquiline (BDQ) and linezolid (LZD) are Group A drugs and form part of shorter and longer BDQ-based regimens under India’s National Tuberculosis (TB) Programme. A syst...
Journal Article
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Research

Clinical utility of target-based next-generation sequencing for drug-resistant TB

Mansoor H, Hirani N, Chavan VV, Das M, Sharma J,  et al.
2023-01-01 • International Journal of Tuberculosis and Lung Disease
2023-01-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
In high TB burden countries, access to drug susceptibility testing is a major bottleneck. Targeted next-generation sequencing (tNGS) is a promising technology for rapid re...
Journal Article
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Research

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study

Huerga H, Bastard M, Lubega AV, Akinyi M, Antabak NT,  et al.
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...
Journal Article
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Research

Scaling up HIV viral load monitoring in Manicaland, Zimbabwe: challenges and opportunities from the field

Nyagadza B, Kudya N, Mbofana E, Masaka S, Garone DB,  et al.
2019-12-21 • Public Health Action
2019-12-21 • Public Health Action
Background: Demand for viral load (VL) monitoring is expected to increase; however, implementation of the multifaceted VL testing poses numerous challenges. We report experiences from Mé...
Journal Article
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Research

Performance of cepheid GeneXpert HIV-1 viral load plasma assay to accurately detect treatment failure: a clinical meta-analysis

Sacks JA, Fong Y, Gonzalez MP, Andreotti M, Baliga S,  et al.
2019-10-01 • AIDS
2019-10-01 • AIDS
BACKGROUND
Coverage of viral load testing remains low with only half of the patients in need having adequate access. Alternative technologies to high throughput centralized machines ...
Journal Article
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Research

Feasibility and acceptability of using the novel urine-based FujiLAM test to detect tuberculosis: A multi-country mixed-methods study

Rucker SCM, Lissouba P, Akinyi M, Lubega AV, Stewart RC,  et al.
2022-05-01 • Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
2022-05-01 • Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
BACKGROUND
The novel urine-based FujiLAM test identifies tuberculosis in HIV-positive patients but may be challenging to use at point-of-care (POC).

OBJECTIVES
We assess...
Journal Article
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Research

Diagnostic performance and usability of the VISITECT CD4 semi-quantitative test for advanced HIV disease screening

Ndlovu Z, Massaquoi L, Bangwen NE, Batumba JN, Bora RU,  et al.
2020-04-03 • PLOS One
2020-04-03 • PLOS One
BACKGROUND
In sub-Saharan Africa, a third of people starting antiretroviral therapy and majority of patients returning to HIV-care after disengagement, present with advanced HIV dise...
Journal Article
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Research

Performance of Cepheid Xpert HIV-1 viral load plasma assay to accurately detect treatment failure

Sacks JA, Fong Y, Gonzalez MP, Andreotti M, Baliga S,  et al.
2019-10-01 • AIDS
2019-10-01 • AIDS
Journal Article
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Commentary

Lay testing cadres and point-of-care diagnostic tests for HIV and other diseases: An essential combination in health service delivery

Ndlovu Z, Ellman T
2021-11-24 • PLOS Medicine
2021-11-24 • PLOS Medicine
SUMMARY POINTS

-- Lack of access to testing plays a major role in the underdiagnosis of infectious and noncommunicable diseases, leading to higher morbidity and mortality.
<...
Conference Material
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Abstract

Validation of GeneXpert testing for human papillomavirus and self-collected sampling for cervical cancer screening in Gutu District, Zimbabwe

Ronoh Y, Some D, Ortuno R, Kuwenyi K, Mupepe T,  et al.
2020-05-20 • MSF Scientific Days International 2020: Research
2020-05-20 • MSF Scientific Days International 2020: Research
INTRODUCTION
Cervical cancer is now largely a preventable disease; however, implementation of highly sensitive molecular screening technologies in low-resource settings is partly hin...
Journal Article
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Research

Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions: a multisite study

Cossa L, Harrison RE, Mpunga J, Lobo S, Kisaka Kimupelenge P,  et al.
2019-10-15 • Global Health Action
2019-10-15 • Global Health Action
Background: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB).
Objective: To assess the feasibility of using LAM to diagnose TB in adult HIV-...
Journal Article
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Review

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices

Ongaro AE, Ndlovu Z, Sollier E, Otieno C, Ondoa P,  et al.
2021-12-31 • Lab on a Chip
2021-12-31 • Lab on a Chip
Single-use, disposable, point-of-care diagnostic devices carry great promise for global health, including meeting urgent needs for testing and diagnosis in places with limited laboratory...
Conference Material
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Slide Presentation

Clinical utility of target-based next-generation sequencing for drug-resistant tuberculosis: a pilot from Mumbai, India

Mansoor H, Hirani N, Chavan VV, Joshi A, Oswal V,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Journal Article
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Commentary

Framework for the implementation of advanced HIV disease diagnostics in sub-Saharan Africa: programmatic perspectives

Ndlovu Z, Burton R, Stewart RC, Bygrave H, Roberts TR,  et al.
2020-05-27 • Lancet HIV
2020-05-27 • Lancet HIV
Conference Material
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Video

Clinical utility of target-based next-generation sequencing for drug-resistant tuberculosis: a pilot from Mumbai, India

Mansoor H, Hirani N, Chavan VV, Joshi A, Oswal V,  et al.
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
No abstract available.