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Showing 1 - 20 of 22 Items
Showing 1 - 20 of 22 Items
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Journal Article
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Review

Lateral flow assay-based CD4 cell count testing for advanced HIV disease

Ndlovu Z, Moore A, Casas EC, Fatti G
2025-05-01 • Lancet HIV
2025-05-01 • Lancet HIV
Journal Article
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Research
Journal Article
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Commentary

From equitable access to equitable innovation: rethinking bioengineering for global health

Street A, Kersaudy Kerhoas M, Ndlovu Z
2024-04-02 • Nature Reviews Bioengineering
2024-04-02 • Nature Reviews Bioengineering
Journal Article
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Research
Conference Material
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Slide Presentation
Conference Material
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Abstract
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research

Performance of Cepheid Xpert HIV-1 viral load plasma assay to accurately detect treatment failure

Sacks JA, Fong Y, 
Journal Article
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Commentary
Conference Material
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Abstract
Journal Article
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Review
Journal Article
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Research
Conference Material
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Slide Presentation
Journal Article
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Commentary

Framework for the implementation of advanced HIV disease diagnostics in sub-Saharan Africa: programmatic perspectives

Ndlovu Z, Burton R, Stewart RC, Bygrave H, Roberts TR,  et al.
2020-05-27 • Lancet HIV
Conference Material
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Video

Clinical utility of target-based next-generation sequencing for drug-resistant tuberculosis: a pilot from Mumbai, India

Mansoor H, Hirani N, Chavan VV, 

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

What does global health equity mean? In bioengineering, ‘equity’ is often interpreted as global ‘access’ to technologies, thereby neglecting wider structural inequalities. Here we sug...

Operationalising targeted next-generation sequencing for routine diagnosis of drug-resistant TB

Iyer AS, Ndlovu Z, Sharma J, Mansoor H, Bharati M,  et al.
2023-06-21 • Public Health Action
2023-06-21 • Public Health Action
BACKGROUND
Phenotypic drug susceptibility testing (pDST) for Mycobacterium tuberculosis can take up to 8 weeks, while conventional molecular tests identify a limited set of resistanc...

High prevalence of bedaquiline and linezolid resistance in extensively drug-resistant tuberculosis patients in a Médecins Sans Frontières clinic, Mumbai, India

Silsarma A, Iyer AS, Galindo MA, Chavan VV, Khan Su,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023

High prevalence of bedaquiline and linezolid resistance in extensively drug-resistant tuberculosis patients in a Médecins Sans Frontières clinic, Mumbai, India

Silsarma A, Iyer AS, Galindo MA, Chavan VV, Khan Su,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
INTRODUCTION
Bedaquiline (BDQ) and linezolid (LZD) are Group A drugs and form part of shorter and longer BDQ-based regimens under India’s National Tuberculosis (TB) Programme. A syst...

Clinical utility of target-based next-generation sequencing for drug-resistant TB

Mansoor H, Hirani N, Chavan VV, Das M, Sharma J,  et al.
2023-01-01 • International Journal of Tuberculosis and Lung Disease
2023-01-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
In high TB burden countries, access to drug susceptibility testing is a major bottleneck. Targeted next-generation sequencing (tNGS) is a promising technology for rapid re...

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study

Huerga H, Bastard M, Lubega AV, Akinyi M, Antabak NT,  et al.
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...

Feasibility and acceptability of using the novel urine-based FujiLAM test to detect tuberculosis: A multi-country mixed-methods study

Rucker SCM, Lissouba P, Akinyi M, Lubega AV, Stewart RC,  et al.
2022-05-01 • Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
2022-05-01 • Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
BACKGROUND
The novel urine-based FujiLAM test identifies tuberculosis in HIV-positive patients but may be challenging to use at point-of-care (POC).

OBJECTIVES
We assess...

Performance of cepheid GeneXpert HIV-1 viral load plasma assay to accurately detect treatment failure: a clinical meta-analysis

Sacks JA, Fong Y, Gonzalez MP, Andreotti M, Baliga S,  et al.
2019-10-01 • AIDS
2019-10-01 • AIDS
BACKGROUND
Coverage of viral load testing remains low with only half of the patients in need having adequate access. Alternative technologies to high throughput centralized machines ...

Scaling up HIV viral load monitoring in Manicaland, Zimbabwe: challenges and opportunities from the field

Nyagadza B, Kudya N, Mbofana E, Masaka S, Garone DB,  et al.
2019-12-21 • Public Health Action
2019-12-21 • Public Health Action
Background: Demand for viral load (VL) monitoring is expected to increase; however, implementation of the multifaceted VL testing poses numerous challenges. We report experiences from Mé...

Diagnostic performance and usability of the VISITECT CD4 semi-quantitative test for advanced HIV disease screening

Ndlovu Z, Massaquoi L, Bangwen NE, Batumba JN, Bora RU,  et al.
2020-04-03 • PLOS One
2020-04-03 • PLOS One
BACKGROUND
In sub-Saharan Africa, a third of people starting antiretroviral therapy and majority of patients returning to HIV-care after disengagement, present with advanced HIV dise...
Gonzalez MP, 
Andreotti M, 
Baliga S, 
et al.
2019-10-01 • AIDS
2019-10-01 • AIDS

Lay testing cadres and point-of-care diagnostic tests for HIV and other diseases: An essential combination in health service delivery

Ndlovu Z, Ellman T
2021-11-24 • PLOS Medicine
2021-11-24 • PLOS Medicine
SUMMARY POINTS

-- Lack of access to testing plays a major role in the underdiagnosis of infectious and noncommunicable diseases, leading to higher morbidity and mortality.
<...

Validation of GeneXpert testing for human papillomavirus and self-collected sampling for cervical cancer screening in Gutu District, Zimbabwe

Ronoh Y, Some D, Ortuno R, Kuwenyi K, Mupepe T,  et al.
2020-05-20 • MSF Scientific Days International 2020
2020-05-20 • MSF Scientific Days International 2020
INTRODUCTION
Cervical cancer is now largely a preventable disease; however, implementation of highly sensitive molecular screening technologies in low-resource settings is partly hin...

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices

Ongaro AE, Ndlovu Z, Sollier E, Otieno C, Ondoa P,  et al.
2021-12-31 • Lab on a Chip
2021-12-31 • Lab on a Chip
Single-use, disposable, point-of-care diagnostic devices carry great promise for global health, including meeting urgent needs for testing and diagnosis in places with limited laboratory...

Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions: a multisite study

Cossa L, Harrison RE, Mpunga J, Lobo S, Kisaka Kimupelenge P,  et al.
2019-10-15 • Global Health Action
2019-10-15 • Global Health Action
Background: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB).
Objective: To assess the feasibility of using LAM to diagnose TB in adult HIV-...

Clinical utility of target-based next-generation sequencing for drug-resistant tuberculosis: a pilot from Mumbai, India

Mansoor H, Hirani N, Chavan VV, Joshi A, Oswal V,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
2020-05-27 • Lancet HIV
Joshi A, 
Oswal V, 
et al.
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
No abstract available.