logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5145.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5145.produseast1
Showing 1 - 20 of 38 Items
Showing 1 - 20 of 38 Items
Sort By: Relevance
  • Newest to oldest
  • Oldest to newest
  • Relevance
Journal Article
|
Research

Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar

Guthmann JP, Pittet A, Lesage A, Imwong M, Lindegardh N,  et al.
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar. METHODS: Enrolled patients at Sonsinphya clinic >6 m...
Journal Article
|
Research

The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos

Guthmann JP, Kasparian S, Phetsouvanh R, Nathan N, Garcia MG,  et al.
2002-09-01 • Annals of Tropical Medicine and Parasitology
2002-09-01 • Annals of Tropical Medicine and Parasitology
To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low...
Journal Article
|
Research

Use of Lot Quality Assurance Sampling (LQAS) to estimate vaccination coverage helps guide future vaccination efforts

Alberti KP, Guthmann JP, Fermon F, Nargaye KD, Grais RF
2008-03-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-03-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Inadequate evaluation of vaccine coverage after mass vaccination campaigns, such as used in national measles control programmes, can lead to inappropriate public health responses. Overes...
Journal Article
|
Research

High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola

Guthmann JP, Cohuet S, Rigutto C, Fortes F, Saraiva N,  et al.
2006-07-01 • American Journal of Tropical Medicine and Hygiene
2006-07-01 • American Journal of Tropical Medicine and Hygiene
In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Co...
Journal Article
|
Research

Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

Rolland E, Checchi F, Pinoges LLP, Balkan S, Guthmann JP,  et al.
2006-04-01 • Tropical Medicine and International Health
2006-04-01 • Tropical Medicine and International Health
OBJECTIVE: To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs). METHODS: We calcul...
Journal Article
|
Research

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Journal Article
|
Research

Outbreak of hepatitis E virus infection in Darfur, Sudan: effectiveness of real-time reverse transcription-PCR analysis of dried blood spots

Merens A, Guerin PJ, Guthmann JP, Nicand E
2009-06-01 • Journal of Clinical Microbiology
2009-06-01 • Journal of Clinical Microbiology
Biological samples collected in refugee camps during an outbreak of hepatitis E were used to compare the accuracy of hepatitis E virus RNA amplification by real-time reverse transcriptio...
Journal Article
|
Research

Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan

Stivanello E, Cavailler P, Cassano F, Omar SV, Kariuki D,  et al.
2004-09-01 • Tropical Medicine and International Health
2004-09-01 • Tropical Medicine and International Health
To provide advice on the rational use of antimalarial drugs, Médecins Sans Frontières conducted a randomized, an open label efficacy study in Kajo Keji, an area of high transmission of m...
Journal Article
|
Research

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: The role of Médecins Sans Frontières

Guthmann JP, Checchi F, van den Broek IVF, Balkan S, Van Herp M,  et al.
2008-08-05 • PLOS Medicine
2008-08-05 • PLOS Medicine
Journal Article
|
Research

Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda

Checchi F, Piola P, Kosack CS, Ardizzoni E, Klarkowski DB,  et al.
2004-04-01 • Tropical Medicine and International Health
2004-04-01 • Tropical Medicine and International Health
We report below an in vivo antimalarial efficacy study conducted in 2002 in Bundi Bugyo, a district of western Uganda housing a large displaced population. We tested sulfadoxine-pyrimeth...
Journal Article
|
Research

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Nicand E, Armstrong GL, Enouf V, Guthmann JP, Guerin JP,  et al.
2005-12-01 • Journal of Medical Virology
2005-12-01 • Journal of Medical Virology
The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced...
Journal Article
|
Research

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone

Grandesso F, Hagerman A, Kamara S, Lam E, Checchi F,  et al.
2006-07-01 • Tropical Medicine and International Health
2006-07-01 • Tropical Medicine and International Health
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous stu...
Journal Article
|
Research

Malaria in camps for internally-displaced persons in Uganda: evaluation of an insecticide-treated bednet distribution programme

Spencer S, Grant AD, Piola P, Tukpo K, Okia M,  et al.
2004-12-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2004-12-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Malaria is a key health problem among displaced populations in malaria-endemic areas. Mass distribution of insecticide-treated bednets (ITN) to prevent malaria is often carried out in co...
Journal Article
|
Research

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JH,  et al.
2007-04-01 • Journal of Infectious Diseases
2007-04-01 • Journal of Infectious Diseases
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudesce...
Journal Article
|
Research

Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial

Piola P, Fogg C, Bajunirwe F, Biraro S, Grandesso F,  et al.
2005-04-23 • Lancet
2005-04-23 • Lancet
BACKGROUND: The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa. However, i...
Journal Article
|
Research

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment

Mugittu K, Priotto G, Guthmann JP, Kiguli J, Adjuik M,  et al.
2007-02-01 • Tropical Medicine and International Health
2007-02-01 • Tropical Medicine and International Health
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115)...
Journal Article
|
Research

Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment

Olliaro PL, Pinoges LLP, Checchi F, Vaillant M, Guthmann JP
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: Parasites may recur asymptomatically after initial clearance by antimalarial treatment. Current guidelines recommend treatment only when patients develop symptoms or at the en...
Journal Article
|
Research

Unacceptably high mortality related to measles epidemics in Niger, Nigeria, and Chad

Grais RF, Dubray C, Gerstl S, Guthmann JP, Djibo A,  et al.
2007-01-01 • PLOS Medicine
2007-01-01 • PLOS Medicine
BACKGROUND: Despite the comprehensive World Health Organization (WHO)/United Nations Children's Fund (UNICEF) measles mortality-reduction strategy and the Measles Initiative, a partnersh...
Journal Article
|
Research

Methodological issues in the assessment of antimalarial drug treatment: Analysis of 13 studies in eight African countries from 2001 to 2004

Guthmann JP, Pinoges LLP, Checchi F, Cousens S, Balkan S,  et al.
2006-11-01 • Antimicrobial Agents and Chemotherapy
2006-11-01 • Antimicrobial Agents and Chemotherapy
The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy ...
Journal Article
|
Research

Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda

Guthmann JP, Ruiz A, Priotto G, Kiguli J, Bonte L,  et al.
2008-02-14 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-02-14 • Transactions of the Royal Society of Tropical Medicine and Hygiene
A study was conducted to measure the overall performance of several rapid diagnostic tests for Plasmodium falciparum infection, in order to select the most appropriate test to be used in...