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The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos | Journal Article / Research | MSF Science Portal
Journal Article
|Research

The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos

Guthmann JP, Kasparian S, Phetsouvanh R, Nathan N, Garcia MG, Phompida S, Brockman A, Gastellu M, Legros D
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Abstract
To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.

Languages

English
DOI
10.1179/000349802125001654
Published Date
01 Sep 2002
PubMed ID
12396318
Journal
Annals of Tropical Medicine and Parasitology
Volume | Issue | Pages
Volume 96, Issue 6
Issue Date
2002-09-01
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