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Clinical best practices for caring for people with expanded resistance to newer TB drugs

Nkomo T, Udwadia Z, Vambe D, van Rie A, Thi S, et al.

2025-06-13 • IJTLD OPEN

BACKGROUND

Strains of Mycobacterium tuberculosis

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Equitable access needed in clinical research

Dang G, Perrin C, Furin J

2025-03-28 • Science

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Equitable access needed in clinical research

Dang G, Perrin C, Furin J

2025-03-28 • Science

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Research

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Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis

Seddon JA, Achar J, Malik AA, Hughes J, Burzynski J, et al.

2025-06-06 • Lancet Infectious Diseases

End of treatment and 12-month post-treatment outcomes in patients treated with all-oral regimens for rifampicin-resistant tuberculosis in Ukraine: a prospective cohort study

Fardhdiani V, Trush O, Lytvynenko N, Pylypchuk S, Terleeva Y, et al.

2025-05-23 • PLOS Global Public Health

The World Health Organization has called for operational research on all-oral shorter regimens for rifampin-resistant and multidrug-resistant forms of tuberculosis (RR/MDR-TB). We fol...

Enhancing tuberculosis (TB) case detection among hospitalized patients through lay health worker led screening: a before-and-after study in KwaZulu-Natal, South Africa

Bulti AB, Dumicho AY, Shigayeva A, Van Cutsem G, Steele SJ, et al.

2025-04-23 • Scientific Reports

Tuberculosis (TB) among hospitalized patients is underdiagnosed. This study assessed systematic TB-screenin...

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R, et al.

2025-02-01 • Lancet Child and Adolescent Health

BACKGROUND

There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially ...

Enhancing tuberculosis (TB) diagnosis among hospitalized patients in KwaZulu-Natal, South Africa: a before-and-after study of a lay health worker-driven intervention

Bulti AB, Dumicho AY, Shigayeva A, van Cutsem G, Steele SJ, et al.

2024-03-08 • Scientific Reports

BACKGROUND

Tuberculosis (TB) among hospitalized patients is underdiagnosed. This study assessed systematic TB-screen...

Standards for clinical trials for treating TB

du Cros PAK, Greig J, Cross GB, Cousins C, Berry C, et al.

2023-12-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
The value, speed of completion and robustness of the evidence generated by TB treatment trials could be improved by implementing standards for best practice.

METH...

Clinical standards for drug-susceptible TB in children and adolescents

Chiang SS, Graham SM, Schaaf HS, Marais BJ, Sant’Anna CC, et al.

2023-08-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
These clinical standards aim to provide guidance for diagnosis, treatment, and management of drug-susceptible TB in children and adolescents.

METHODS
Fifty-tw...

Diagnostics to support the scaling up of shorter, safer tuberculosis regimens

Branigan D, Denkinger CM, Furin J, Heitkamp P, Deborggraeve S, et al.

2023-07-31 • Lancet Microbe

Caring for adolescents and young adults with tuberculosis or at risk of tuberculosis: Consensus statement from an international expert panel

Chiang SS, Waterous PM, Atieno VF, Bernays S, Bondarenko Y, et al.

2023-03-01 • Journal of Adolescent Health

Tuberculosis diagnosis and preventive monotherapy among children and adolescents exposed to rifampicin-resistant tuberculosis in the household

Apolisi I, Cox HS, Tyeku N, Daniels J, Mathee S, et al.

2023-02-21 • Open Forum Infectious Diseases

BACKGROUND
Children and adolescents with household exposure to multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) are at high risk of developing TB disease. Tuberculosis pre...

Demanding an end to tuberculosis: treatment of tuberculosis infection among persons living with and without HIV

Fargher J, Reuter A, Furin J

2019-01-01 • Current Opinion in HIV and AIDS

PURPOSE OF REVIEW
More than two billion people are infected with Mycobacterium tuberculosis and few of them are ever offered therapy in spite of such treatment being associated with ...

The need to accelerate access to new drugs for multidrug-resistant tuberculosis

Cox HS, Furin J, Mitnick CD, Daniels C, Cox V, et al.

2015-07-01 • Bulletin of the World Health Organization

Approximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10...

The Epidemiology, Pathogenesis, Transmission, Diagnosis, and Management of Multidrug-Resistant, Extensively Drug-Resistant, and Incurable Tuberculosis

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, et al.

2017-03-15 • Lancet Respiratory Medicine

Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tube...

TB screening, prevention and treatment cascade in a Malawi prison

Mangochi P, Bossard C, Catacutan C, Van Laeken D, Kwitonda C, et al.

2022-10-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
Incarcerated individuals, especially in high HIV and TB burden settings, are at increased risk of latent TB infection and/or TB disease. We implemented a comprehensive HIV...

How COVID-19 could benefit tuberculosis and HIV services in South Africa

Keene CM, Mohr-Holland E, Cassidy T, Scott V, Nelson AM, et al.

2020-09-01 • Lancet Respiratory Medicine

A positive COVID-19 test is associated with high mortality in RR-TB-HIV patients

Mohr-Holland E, Daniels J, Douglas-Jones B, Mema N, Scott V, et al.

2021-05-01 • International Journal of Tuberculosis and Lung Disease

'I'm fed up': experiences of prior anti-tuberculosis treatment in patients with drug-resistant tuberculosis and HIV

Furin J, Isaakidis P, Reid AJ, Kielmann K

2014-10-03 • International Journal of Tuberculosis and Lung Disease

OBJECTIVES
To understand the impact of past experiences of anti-tuberculosis treatment among patients co-infected with the human immunodeficiency virus and multidrug-resistant tuberc...

Universal regimens or universal access to drug susceptibility testing for tuberculosis?

Acquah R, Furin J

2019-03-01 • Lancet Infectious Diseases

A universal regimen. At times this appears to be the Holy Grail in tuberculosis treatment. For decades, policy makers, public health specialists, and donors have argued that in order to ...