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Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 17 of 17 Items
Showing 1 - 17 of 17 Items
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Journal Article
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Research

Xpert-Ultra assay on stool and urine to improve tuberculosis diagnosis in children: the Médecins Sans Frontières experience in Guinea-Bissau and South Sudan

Moretó-Planas L, Mahajan R, Fidelle Nyikayo L, Ajack YBP, Tut Chol B,  et al.
2024-05-02 • Open Forum Infectious Diseases
2024-05-02 • Open Forum Infectious Diseases
BACKGROUND
Over half of childhood tuberculosis (TB) remains undiagnosed yearly. WHO recommends Xpert-Ultra as a first paediatric diagnosis test, but microbiological confirmation rema...
Journal Article
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Research

Aetiology of non-malaria acute febrile illness fever in children in rural Guinea-Bissau: a prospective cross-sectional investigation

Gutierrez R, Landa M, Sambou M, Bassane H, Dia N,  et al.
2024-03-21 • Frontiers in Epidemiology
2024-03-21 • Frontiers in Epidemiology
BACKGROUND
With growing use of parasitological tests to detect malaria and decreasing incidence of the disease in Africa; it becomes necessary to increase the understanding of causes...
Conference Material
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Poster

Innovative laboratory tools to improve tuberculosis diagnosis in children

Moreto-Planas L, Mahajan R, Sagrado MJ, Flevaud L, Gallo J,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
Journal Article
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Short Report

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan

Molina-de la Fuente I, Benito MJS, Flevaud L, Ousley J, Pasquale HA,  et al.
2023-01-01 • Emerging Infectious Diseases
2023-01-01 • Emerging Infectious Diseases
Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for ...
Journal Article
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Commentary

Target product profile (TPP) for Chagas disease point-of-care diagnosis and assessment of response to treatment

Porras AI, Yadon ZE, Altcheh J, Britto C, Chaves GC,  et al.
2015-06-04 • PLOS Neglected Tropical Diseases
2015-06-04 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières

Yun O, Lima MA, Ellman T, Chambi W, Castillo S,  et al.
2009-07-07 • PLOS Neglected Tropical Diseases
2009-07-07 • PLOS Neglected Tropical Diseases
BACKGROUND:
Chagas disease (American trypanosomiasis) is a zoonotic or anthropozoonotic disease caused by the parasite Trypanosoma cruzi. Predominantly affecting populations in poor...
Journal Article
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Research

Diagnostic accuracy of commercially available immunochromatographic rapid tests for diagnosis of dengue in India

Mahajan R, Nair MM, Saldanha AM, Harshana A, de Lima Pereira A,  et al.
2021-07-01 • Journal of Vector Borne Diseases
2021-07-01 • Journal of Vector Borne Diseases
BACKGROUND AND OBJECTIVES
There is limited evidence regarding the accuracy of dengue rapid diagnostic kits despite their extensive use in India. We evaluated the performance of four ...
Journal Article
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Commentary

NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

Yun O, Priotto G, Tong J, Flevaud L, Chappuis F
2010-05-25 • PLOS Neglected Tropical Diseases
2010-05-25 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Real-Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates

Parrado R, Ramirez JC, de la Barra A, Alonso-Vega C, Juiz N,  et al.
2018-12-03 • Antimicrobial Agents and Chemotherapy
2018-12-03 • Antimicrobial Agents and Chemotherapy
This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time PCR (qPCR) for baseline detection and quantification of parasitic loads and post-trea...
Journal Article
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Short Report

Human African trypanosomiasis in areas without surveillance

Chappuis F, Lima MA, Flevaud L, Ritmeijer KKD
2010-02-01 • Emerging Infectious Diseases
2010-02-01 • Emerging Infectious Diseases
Journal Article
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Research

First external Quality Assurance Program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease

Ramirez JC, Parrado R, Sulleiro E, de la Barra A, Rodriguez M,  et al.
2017-11-27 • PLOS One
2017-11-27 • PLOS One
Real-Time PCR (qPCR) testing is recommended as both a diagnostic and outcome measurement of etiological treatment in clinical practice and clinical trials of Chagas disease (CD), but no ...
Journal Article
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Research

Early prediction of treatment efficacy in Second-Stage Gambiense Human African Trypanosomiasis

Priotto G, Chappuis F, Bastard M, Flevaud L, Etard JF
2012-06-05 • PLOS Neglected Tropical Diseases
2012-06-05 • PLOS Neglected Tropical Diseases
Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in ...
Journal Article
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Research

Evaluation of Clinical and Immunological Markers for predicting Virological Failure in a HIV/AIDS treatment cohort in Busia, Kenya

Ferreyra C, Yun O, Eisenberg N, Alonso E, Khamadi AS,  et al.
2012-11-21 • PLOS One
2012-11-21 • PLOS One
In resource-limited settings where viral load (VL) monitoring is scarce or unavailable, clinicians must use immunological and clinical criteria to define HIV virological treatment failur...
Journal Article
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Commentary

Development of diagnostics for Chagas disease: where should we put our limited resources?

Picado A, Angheben A, Marchiol A, Alarcón de Noya B, Flevaud L,  et al.
2017-01-05 • PLOS Neglected Tropical Diseases
2017-01-05 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Copan eNAT Transport System to Address Challenges in COVID-19 Diagnostics in Regions with Limited Testing Access

Richard-Greenblatt M, Comar CE, Flevaud L, Berti M, Harris RM,  et al.
2021-04-20 • Journal of Clinical Microbiology
2021-04-20 • Journal of Clinical Microbiology
Community-based healthcare clinics and hospital outreach services have the potential to expand coronavirus disease 2019 (COVID-19) diagnostics to rural areas. However, reduced specimen s...
Journal Article
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Research

Liposomal amphotericin B for visceral leishmaniasis in human immunodeficiency virus-coinfected patients: 2-year treatment outcomes in Bihar, India

Sinha PK, van Griensven J, Pandey K, Kumar N, Verma N,  et al.
2011-10-01 • Clinical Infectious Diseases
2011-10-01 • Clinical Infectious Diseases
Reports on treatment outcomes of visceral leishmaniasis (VL)-human immunodeficiency virus (HIV) coinfection in India are lacking. To our knowledge, none have studied the efficacy of lipo...
Journal Article
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Research

Natural history of a visceral leishmaniasis outbreak in highland Ethiopia

Herrero M, Orfanos G, Argaw D, Mulugeta A, Aparicio P,  et al.
2009-09-01 • American Journal of Tropical Medicine and Hygiene
2009-09-01 • American Journal of Tropical Medicine and Hygiene
In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemken, Ethiopia, a highland region where only few cases had been reported before. We analyzed records ...