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Showing 1 - 20 of 23 Items
Showing 1 - 20 of 23 Items
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Research

Pharmacokinetics of rifampicin and isoniazid in patients with HIV–tuberculosis coinfection receiving efavirenz-based antiretroviral treatment: an ANRS12292–RIFAVIRENZ sub-study

Gelé T, Atwine D, Baudin E, Muyindike W, Mworozi K,  et al.
2025-08-29 • Journal of Antimicrobial Chemotherapy
2025-08-29 • Journal of Antimicrobial Chemotherapy

BACKGROUND

Increasing rifampicin dosing is considered a potent strategy for shortening TB treatment ...

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Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children

Delmas V, Vasiliu A, Tchakounté Youngui B, Ssekyanzi B, Kuate Kuate A,  et al.
2025-06-27 • International Journal of Tuberculosis and Lung Disease
2025-06-27 • International Journal of Tuberculosis and Lung Disease

BACKGROUND

The ‘CaP-TB’ project enhanced paediatric TB care through decentralized services, including screening, specimen collection, chest X-rays and implement...

Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study

Lounnas M, Masama EN, Beneteau S, Kasakwa K, Kaitano R,  et al.
2025-06-01 • Lancet Microbe
2025-06-01 • Lancet Microbe

BACKGROUND

WHO recommends Xpert MTB/RIF Ultra (Ultra) for stool testing for tuberculosis diagnosis in children. Stool processing requires removal of debris and ...

Integration of HIV testing in a community intervention for tuberculosis screening among household contacts of patients with tuberculosis in Cameroon and Uganda

Youngui BT, Atwine D, Otai D, Vasiliu A, Ssekyanzi B,  et al.
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
INTRODUCTION
People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore cri...

Effectiveness of a community-based approach for the investigation and management of children with household tuberculosis contact in Cameroon and Uganda: a cluster-randomised trial

Bonnet MMB, Vasiliu A, Tchounga BK, Cuer B, Fielding K,  et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing chi...

Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial

Mafirakureva N, Tchounga BK, Mukherjee S, Youngui BT, Ssekyanzi B,  et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children. The CONTACT trial found in...

Four-month high-dose rifampicin regimens for pulmonary tuberculosis

Jindani A, Atwine D, Grint D, Bah B, Adams J,  et al.
2023-09-01 • NEJM Evidence
2023-09-01 • NEJM Evidence
BACKGROUND
Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid a...

Assessment of the proportion of households with burn victims, associated risk factors and knowledge of burn injury prevention strategies in South Western Uganda. A population based cross sectional survey

Martin T, Nanjebe D, Atwine D
2023-03-01 • Burns
2023-03-01 • Burns
BACKGROUND
Burn injuries are a major cause of morbidity and mortality within Low- and Middle-income countries (LMICs). Most of these burn injuries occur at home with children most a...

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study

Huerga H, Bastard M, Lubega AV, Akinyi M, Antabak NT,  et al.
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...

Evaluation of the SD Bioline TB Ag MPT64 test for identification of Mycobacterium tuberculosis complex from liquid cultures in southwestern Uganda

Orikiriza P, Nyehangane D, Atwine D, Kisakye JJ, Kassaza K,  et al.
2017-03-31 • East African Medical Journal
2017-03-31 • East African Medical Journal
BACKGROUND
To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that ...

Increased child contact investigation and tuberculosis preventive treatment management through a community-based intervention in Cameroon and Uganda: Results of the contact cluster randomized trial

Atwine D
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
CONTEXT
In tuberculosis (TB) endemic countries, the screening and management of household contacts remains low including the uptake of TB preventive treatment (TPT). One of the chall...

A randomised phase II trial to evaluate the toxicity of high-dose rifampicin to treat pulmonary tuberculosis

Jindani A, Borgulya G, de Patino IW, Gonzales T, de Fernandes RA,  et al.
2016-06-01 • International Journal of Tuberculosis and Lung Disease
2016-06-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Randomised Phase IIB clinical trial.

OBJECTIVES
To assess whether increasing the dose of rifampicin (RMP) from 10 mg/kg to 15 or 20 mg/kg results in an increase ...

Intra-gastric string test: an effective tool for diagnosing tuberculosis in adults unable to produce sputum

Atwine D, Nansumba M, Orikiriza P, Riera M, Nackers F,  et al.
2015-05-01 • International Journal of Tuberculosis and Lung Disease
2015-05-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Tuberculosis (TB) diagnosis is challenging in patients who are unable to produce sputum. The string test, a method for retrieving enteropathogens, is a potential alternative ...

Xpert(®) MTB/RIF for detection of Mycobacterium tuberculosis from frozen string and induced sputum sediments

Atwebembeire J, Orikiriza P, Bonnet MMB, Atwine D, Katawera V,  et al.
2016-08-01 • International Journal of Tuberculosis and Lung Disease
2016-08-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Although it is now widely used for tuberculosis (TB) diagnosis, Xpert® MTB/RIF availability remains inadequate in low-resource settings. Moreover, its accuracy in testing sto...

Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda

Bonnet MMB, Kyakwera C, Kyomugasho N, Atwine D, Mugabe F,  et al.
2017-08-01 • International Journal of Tuberculosis and Lung Disease
2017-08-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficult...

Non-disclosure of tuberculosis diagnosis by patients to their household members in south western Uganda

Nyangoma M, Bajunirwe F, Atwine D
2020-01-24 • PLOS One
2020-01-24 • PLOS One
Background
Tuberculosis (TB) non-disclosure by adult patients to all household members is a setback to TB control efforts. It reduces the likelihood that household contacts will see...

Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug-drug interaction randomized trial

Atwine D, Baudin E, Gele T, Muyindike WR, Mworozi K,  et al.
2020-01-30 • Journal of Antimicrobial Chemotherapy
2020-01-30 • Journal of Antimicrobial Chemotherapy
Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown.

Objectives: To assess the effect o...

Use of Colorimetric Culture Methods for Detection of Mycobacterium Tuberculosis Complex Isolates from Sputum Samples in Resource-Limited Settings

Orikiriza P, Rojas-Ponce G, Riera-Montes M, Atwine D, Nansumba M,  et al.
2013-05-08 • Journal of Clinical Microbiology
2013-05-08 • Journal of Clinical Microbiology
Despite recent advances, tuberculosis (TB) diagnosis remains imperfect in resource-limited settings due to its complexity and costs, poor sensitivity of available tests, or long times to...

Effect of Male Involvement on the Nutritional Status of Children Less Than 5 Years: A Cross Sectional Study in a Rural Southwestern District of Uganda

Kansiime N, Atwine D, Nuwamanya S, Bagenda F
2017-12-04 • Journal of Nutrition and Metabolism
2017-12-04 • Journal of Nutrition and Metabolism
Undernutrition among children less than 5 years is still a public health concern in most developing countries. Fathers play a critical role in providing support in improving maternal and...

Predictors of delayed culture conversion among Ugandan patients

Atwine D, Orikiriza P, Taremwa IM, Ayebare A, Logoose S,  et al.
2017-04-24 • BMC Infectious Diseases
2017-04-24 • BMC Infectious Diseases
BACKGROUND
Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower...