Showing 1 - 20 of 20 Items
Showing 1 - 20 of 20 Items
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Journal Article
|Research
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
INTRODUCTION
People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore cri...
People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore cri...
Journal Article
|Research
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing chi...
Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing chi...
Journal Article
|Research
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children. The CONTACT trial found in...
WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children. The CONTACT trial found in...
Journal Article
|Research
2023-09-01 • NEJM Evidence
2023-09-01 • NEJM Evidence
BACKGROUND
Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid a...
Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid a...
Journal Article
|Research
2023-03-01 • Burns
2023-03-01 • Burns
BACKGROUND
Burn injuries are a major cause of morbidity and mortality within Low- and Middle-income countries (LMICs). Most of these burn injuries occur at home with children most a...
Burn injuries are a major cause of morbidity and mortality within Low- and Middle-income countries (LMICs). Most of these burn injuries occur at home with children most a...
Journal Article
|Research
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...
Journal Article
|Research
2017-03-31 • East African Medical Journal
2017-03-31 • East African Medical Journal
BACKGROUND
To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that ...
To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that ...
Journal Article
|Research
2015-05-01 • International Journal of Tuberculosis and Lung Disease
2015-05-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Tuberculosis (TB) diagnosis is challenging in patients who are unable to produce sputum. The string test, a method for retrieving enteropathogens, is a potential alternative ...
Tuberculosis (TB) diagnosis is challenging in patients who are unable to produce sputum. The string test, a method for retrieving enteropathogens, is a potential alternative ...
Conference Material
|Abstract
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
CONTEXT
In tuberculosis (TB) endemic countries, the screening and management of household contacts remains low including the uptake of TB preventive treatment (TPT). One of the chall...
In tuberculosis (TB) endemic countries, the screening and management of household contacts remains low including the uptake of TB preventive treatment (TPT). One of the chall...
Journal Article
|Research
2016-06-01 • International Journal of Tuberculosis and Lung Disease
2016-06-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Randomised Phase IIB clinical trial.
OBJECTIVES
To assess whether increasing the dose of rifampicin (RMP) from 10 mg/kg to 15 or 20 mg/kg results in an increase ...
Randomised Phase IIB clinical trial.
OBJECTIVES
To assess whether increasing the dose of rifampicin (RMP) from 10 mg/kg to 15 or 20 mg/kg results in an increase ...
Journal Article
|Research
2016-08-01 • International Journal of Tuberculosis and Lung Disease
2016-08-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Although it is now widely used for tuberculosis (TB) diagnosis, Xpert® MTB/RIF availability remains inadequate in low-resource settings. Moreover, its accuracy in testing sto...
Although it is now widely used for tuberculosis (TB) diagnosis, Xpert® MTB/RIF availability remains inadequate in low-resource settings. Moreover, its accuracy in testing sto...
Journal Article
|Research
2017-08-01 • International Journal of Tuberculosis and Lung Disease
2017-08-01 • International Journal of Tuberculosis and Lung Disease
SETTING
Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficult...
Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficult...
Journal Article
|Research
2020-01-24 • PLOS One
2020-01-24 • PLOS One
Background
Tuberculosis (TB) non-disclosure by adult patients to all household members is a setback to TB control efforts. It reduces the likelihood that household contacts will see...
Tuberculosis (TB) non-disclosure by adult patients to all household members is a setback to TB control efforts. It reduces the likelihood that household contacts will see...
Journal Article
|Research
Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug-drug interaction randomized trial
2020-01-30 • Journal of Antimicrobial Chemotherapy
2020-01-30 • Journal of Antimicrobial Chemotherapy
Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown.
Objectives: To assess the effect o...
Objectives: To assess the effect o...
Journal Article
|Research
2013-05-08 • Journal of Clinical Microbiology
2013-05-08 • Journal of Clinical Microbiology
Despite recent advances, tuberculosis (TB) diagnosis remains imperfect in resource-limited settings due to its complexity and costs, poor sensitivity of available tests, or long times to...
Journal Article
|Research
2017-12-04 • Journal of Nutrition and Metabolism
2017-12-04 • Journal of Nutrition and Metabolism
Undernutrition among children less than 5 years is still a public health concern in most developing countries. Fathers play a critical role in providing support in improving maternal and...
Journal Article
|Research
2017-04-24 • BMC Infectious Diseases
2017-04-24 • BMC Infectious Diseases
BACKGROUND
Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower...
Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower...
Journal Article
|Research
2014-12-10 • BMC Infectious Diseases
2014-12-10 • BMC Infectious Diseases
BackgroundLittle is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculo...
Journal Article
|Research
2022-02-11 • Pilot and Feasibility Studies
2022-02-11 • Pilot and Feasibility Studies
BACKGROUND
One of the main barriers of the management of household tuberculosis child contacts is the necessity for parents to bring healthy children to the facility. We assessed the...
One of the main barriers of the management of household tuberculosis child contacts is the necessity for parents to bring healthy children to the facility. We assessed the...
Journal Article
|Review
2018-05-22 • British Journal of Clinical Pharmacology
2018-05-22 • British Journal of Clinical Pharmacology
AIMS
Efavirenz (EFV) and rifampicin-isoniazid (RH) are cornerstone drugs in human immunodeficiency virus (HIV)-tuberculosis (TB) coinfection treatment but with complex drug interacti...
Efavirenz (EFV) and rifampicin-isoniazid (RH) are cornerstone drugs in human immunodeficiency virus (HIV)-tuberculosis (TB) coinfection treatment but with complex drug interacti...