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Humanitarian action & health systems (MSF Scientific Days International 2022) | Collections | MSF Science Portal

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Expanding access to lifesaving new TB tools
Expanding access to lifesaving new TB tools
Many settings with a high burden of drug-resistant tuberculosis (DR-TB) lack access to advanced diagnostics and to groundbreaking new treatments. The Collection linked below spotlights work by MSF and collaborators to analyze barriers, identify gaps, and accelerate the roll-out of these tools to people whose lives hang in the balance. Several reports examine price, regulatory, and patent obstacles that persist despite considerable public investment into developing many of these tools. Other authors examine critical remaining weaknesses in care pathways—especially in screening and diagnosis, and particularly in children. Several studies describe new strategies that could be part of the solution, from a pilot program in Tajikisttan that trains family caregivers to treat children with DR-TB at home, to a person-centered care model adapted to a conflict zone in Afghanistan. Lastly, initial findings demonstrate that pregnant women—another vulnerable population—can be effectively treated for DR- and multidrug-resistant TB, improving maternal outcomes without harming neonates.
Snakebite envenoming: a neglected health crisis
Snakebite envenoming: a neglected health crisis

Every year 2 million or more people fall victim to snakebite envenoming, mostly in poor, rural communities of Africa, Asia and Latin America. Between 83,000—138,000 of them die, while hundreds of thousands more suffer debilitating long-term complications or disabilities.


Although some antivenom medicines are highly effective when used promptly and appropriately, many snakebite victims get no treatment at all. Those who do may receive antivenoms which don’t work against the type of snake that bit them, or were not rigorously tested for safety and effectiveness.


To mark World Snakebite Awareness Day on September 19th, the Collection linked below brings together recent MSF work on this highly neglected disease. Several articles and conference presentations help fill evidence gaps on the burden of disease and its impacts or on treatment outcomes with specific antivenoms. Others examine how to tackle the formidable challenges of availability and affordability, the absence of regulatory oversight for making, testing and registering antivenoms, and the anemic R&D pipeline for new products—all of which impede access for patients to safe, effective treatment tailored to local snake species.

TB-PRACTECAL Trial—Evidence for a shorter, safer, more effective treatment for drug-resistant tuberculosis
TB-PRACTECAL Trial—Evidence for a shorter, safer, more effect...
Drug-resistant tuberculosis (DR-TB) remains an especially deadly form of the ancient scourge of TB, while current treatments are long, toxic, and ineffective for half of all patients. Aiming to change this unacceptable status quo, in the mid-2010’s MSF and partners launched three clinical trials to test novel regimens containing the first new TB drugs in decades. On 22 December 2022 the New England Journal of Medicine published findings from TB-PRACTECAL, a three-country randomized controlled trial, showing that a shorter regimen is safer and cured 89% of DR-TB patients, compared with 52% on the standard of care. These findings have already been incorporated into the World Health Organization’s new TB treatment guidelines. A separate study shows that the new regimen is also more cost-effective. Alongside these results the content collection linked below highlights other aspects of the trial, from community engagement strategies that helped shape TB-PRACTECAL to setbacks arising from the Covid-19 pandemic. It also examines urgent challenges in scaling up access to these life-saving drugs, including affordability and patent barriers.
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Conference Material
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Video

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Video

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Humanitarian action & health systems (MSF Scientific Days International 2022)

Humanitarian action & health systems (MSF Scientific Days International 2022)

Conference Material
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Video

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Video

Fixed dose combination drugs for cardiovascular disease in Lebanon

Boulle P
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Abstract

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS, Niyonzima E, Cisse I, Pagola-Ugarte M, Savane I,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022

INTRODUCTION

Guinea’s Ministry of Health has proposed a standardized national community health program, including health promotion, case management, and referral; historically h...

Conference Material
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Slide Presentation

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS, Niyonzima E, Cisse I, Pagola-Ugarte M, Savane I,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM, Teal J, Schausberger B, Sankoh M, Conteh AB,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
MSF and the MoHS implemented a partnership model of free and accessible maternal and child healthcare at primary and hospital-level health facilities in Tonkolili Distri...
Conference Material
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Slide Presentation

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM, Teal J, Schausberger B, Sankoh M, Conteh AB,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings: an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A, Hetzel M, Tshefu AK, Omoluabi E, Awor P,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
In sub-Saharan Africa, over 400,000 children die annually from malaria and other preventable illnesses. Little is known about where these children die, from which causes...
Conference Material
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Slide Presentation

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A, Hetzel M, Tshefu AK, Omoluabi E, Awor P,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Fixed dose combination drugs for cardiovascular disease in Lebanon

Ansbro E, Masri S, Prieto-Merino D, Bahous SA, Molfino L,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
Cardiovascular disease (CVD) is the leading cause of death and disability globally, including in humanitarian contexts. Fixed-dose combination (FDC) drugs are cost-effec...
Conference Material
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Slide Presentation

Fixed dose combination drugs for cardiovascular disease in Lebanon

Ansbro E, Masri S, Prieto-Merino D, Bahous SA, Molfino L,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022