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Humanitarian action & health systems (MSF Scientific Days International 2022) | Collections | MSF Science Portal

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TB-PRACTECAL Trial—Evidence for a shorter, safer, more effective treatment for drug-resistant tuberculosis
TB-PRACTECAL Trial—Evidence for a shorter, safer, more effect...
Drug-resistant tuberculosis (DR-TB) remains an especially deadly form of the ancient scourge of TB, while current treatments are long, toxic, and ineffective for half of all patients. Aiming to change this unacceptable status quo, in the mid-2010’s MSF and partners launched three clinical trials to test novel regimens containing the first new TB drugs in decades. On 22 December 2022 the New England Journal of Medicine published findings from TB-PRACTECAL, a three-country randomized controlled trial, showing that a shorter regimen is safer and cured 89% of DR-TB patients, compared with 52% on the standard of care. These findings have already been incorporated into the World Health Organization’s new TB treatment guidelines. A separate study shows that the new regimen is also more cost-effective. Alongside these results the content collection linked below highlights other aspects of the trial, from community engagement strategies that helped shape TB-PRACTECAL to setbacks arising from the Covid-19 pandemic. It also examines urgent challenges in scaling up access to these life-saving drugs, including affordability and patent barriers.
TB Union Conference 2022
TB Union Conference 2022
Innovation in preventing, diagnosing and treating drug-resistant tuberculosis (DR-TB) cannot come fast enough—especially given the ground lost due to the Covid-19 pandemic, and with only 1 in 3 people who have DR-TB now receiving care. The content collection linked below offers a snapshot of recent TB work by MSF and collaborators to help change this picture. The TB-PRACTECAL and endTB studies have delivered clear evidence for shorter, safer, more effective treatments against drug-resistant (DR)-TB. Faced with the many hurdles that lie ahead before these and other critical interventions can be widely accessible, other studies investigate patient/family-based models of care adapted to complex settings and neglected groups, including children. Last, several authors explore limited but potentially important options for expanding diagnosis and preventive treatment.
The climate crisis and health in humanitarian settings
The climate crisis and health in humanitarian settings
The climate crisis is also a health and humanitarian crisis, disproportionately impacting people in the world’s most climate-sensitive regions—mainly low- and low-middle income countries with the least capacity to respond. MSF and other humanitarian organizations witness the consequences daily. More frequent, intense weather events and a warming planet contribute to food and water scarcity, more severe and widespread disease outbreaks, and more injuries and preventable deaths. They also drive massive population displacement, with over 32 million people fleeing their homes in 2022 alone due to floods, drought, storms and fire—nearly triple the number displaced by violence and conflict. To mark Earth Day 2024 (22 April) we present a cross-section of work by MSF and collaborators, drawing from a range of data sources and from first-hand experience at our medical projects. Emphasizing the urgency of adapting humanitarian operations to the climate crisis, the collection also explores loss and damage through a health lens, proposes policies and practices for creating climate-resilient health organizations, and advocates for embedding fair, just ethics perspectives into humanitarian action and research on climate.
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Conference Material
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Video

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Humanitarian action & health systems (MSF Scientific Days International 2022)

Humanitarian action & health systems (MSF Scientific Days International 2022)

Conference Material
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Video

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Video

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Video

Fixed dose combination drugs for cardiovascular disease in Lebanon

Boulle P
2022-06-07 • MSF Scientific Days International 2022
2022-06-07 • MSF Scientific Days International 2022
Conference Material
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Abstract

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS, Niyonzima E, Cisse I, Pagola-Ugarte M, Savane I,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022

INTRODUCTION

Guinea’s Ministry of Health has proposed a standardized national community health program, including health promotion, case management, and referral; historically h...

Conference Material
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Slide Presentation

Models for community health programmes supported by different actors: mixed methods study, Guinea

Komano MS, Niyonzima E, Cisse I, Pagola-Ugarte M, Savane I,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM, Teal J, Schausberger B, Sankoh M, Conteh AB,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
MSF and the MoHS implemented a partnership model of free and accessible maternal and child healthcare at primary and hospital-level health facilities in Tonkolili Distri...
Conference Material
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Slide Presentation

Safe motherhood and childhood in Sierra Leone: key findings from mixed-methods health-seeking behaviour study

Lavilla KM, Teal J, Schausberger B, Sankoh M, Conteh AB,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings: an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A, Hetzel M, Tshefu AK, Omoluabi E, Awor P,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
In sub-Saharan Africa, over 400,000 children die annually from malaria and other preventable illnesses. Little is known about where these children die, from which causes...
Conference Material
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Slide Presentation

Understanding and improving case management of severe febrile illness in highly malaria-endemic settings an observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda

Signorell A, Hetzel M, Tshefu AK, Omoluabi E, Awor P,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
Conference Material
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Abstract

Fixed dose combination drugs for cardiovascular disease in Lebanon

Ansbro E, Masri S, Prieto-Merino D, Bahous SA, Molfino L,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022
INTRODUCTION
Cardiovascular disease (CVD) is the leading cause of death and disability globally, including in humanitarian contexts. Fixed-dose combination (FDC) drugs are cost-effec...
Conference Material
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Slide Presentation

Fixed dose combination drugs for cardiovascular disease in Lebanon

Ansbro E, Masri S, Prieto-Merino D, Bahous SA, Molfino L,  et al.
2022-05-11 • MSF Scientific Days International 2022
2022-05-11 • MSF Scientific Days International 2022