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Mini-Lab—MSF's simplified bacteriology laboratory for low-resource settings | Collections | MSF Science Portal

Resistance to antibiotics is a growing public health crisis, especially in countries with fragile health systems and in regions at war. One key limitation in most of these settings is a lack of clinical bacteriology laboratory capacity, which leaves medical providers without ways to accurately diagnose patient infections and to tailor antibiotic treatment accordingly.

To help fill this critical gap, MSF and partners have developed the Mini-Lab—a small-scale, standalone lab that is easy to transport, set up and operate by staff after only a short training. Its six modules are stocked with everything needed to diagnose common bloodstream and urinary tract infections and to perform antibiotic sensitivity testing using methods adapted to extremely hot climates and remote settings.

With Mini-Lab now being rolled out to selected MSF projects, here we highlight the background to its development and some of the research behind the bacteriological tests it incorporates.

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Nursing care at MSF
Nursing care at MSF
Nurses spend more time at the bedside than any other healthcare workers and are a cornerstone of quality, person-centered clinical care in MSF health facilities. Through research, MSF has also shown that empowering nurses can also help expand patient access to care. In this collection, we highlight some of the evidence gathered on nurse-led care models at MSF projects, including through strategies that strengthen nurses through innovative training approaches and bedside tools.
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Costs, cost-effectiveness, and financing of tuberculosis trea...

Tuberculosis (TB) is the world's deadliest infectious disease, and the leading killer of people with HIV. TB is curable, but it can be difficult to diagnose and tough to treat, especially for increasingly prevalent drug-resistant TB. In 2023, 22,700 people started TB treatment in MSF programs. Understanding the costs and cost-effectiveness associated with TB treatment and innovations, ranging from TB diagnostics and medications to TB care models, can help to plan resource needs and allocate resources effectively. Analyzing financing mechanisms can support developing sustainable funding models for TB control.

This collection spotlights articles by MSF and collaborators to analyze and document the costs of care, particularly diagnostics and medications.

Humanitarian action & health systems (MSF Scientific Days International 2022)
Humanitarian action & health systems (MSF Scientific Days Int...
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Journal Article
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Research

Validation of three MicroScan® antimicrobial susceptibility testing plates designed for low-resource settings

Ronat JB, Oueslati S, Natale A, Kesteman T, Elamin W,  et al.
2022-08-30 • Diagnostics
2022-08-30 • Diagnostics
Easy and robust antimicrobial susceptibility testing (AST) methods are essential in clinical bacteriology laboratories (CBL) in low-resource settings (LRS). We evaluated the Beckman Coul...
Journal Article
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Research

Biphasic versus monophasic manual blood culture bottles for low-resource settings: an in-vitro study

Ombelet S, Natale A, Ronat JB, Kesteman T, Vandenberg O,  et al.
2021-12-13 • Lancet Microbe
2021-12-13 • Lancet Microbe
BACKGROUND
Manual blood culture bottles (BCBs) are frequently used in low-resource settings. There are few BCB performance evaluations, especially evaluations comparing them with aut...
Journal Article
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Review

AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

Ronat JB, Natale A, Kesteman T, Andremont A, Elamin W,  et al.
2021-10-01 • Clinical Microbiology and Infection
2021-10-01 • Clinical Microbiology and Infection
BACKGROUND
In low- and middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental ...
Conference Material
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Video

Development of an all-in-one transportable clinical bacteriology laboratory: Feedback from testing the MSF Mini-Lab development project in Haiti

Ronat JB
2021-08-25 • MSF Scientific Days Asia 2021
2021-08-25 • MSF Scientific Days Asia 2021
Journal Article
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Research

Evaluation of MicroScan bacterial identification panels for low-resource settings

Ombelet S, Natale A, Ronat JB, Vandenberg O, Hardy L,  et al.
2021-02-19 • Diagnostics
2021-02-19 • Diagnostics
Bacterial identification is challenging in low-resource settings (LRS). We evaluated the MicroScan identification panels (Beckman Coulter, Brea, CA, USA) as part of Médecins Sans Frontiè...
Journal Article
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Commentary

The Mini-Lab: accessible clinical bacteriology for low-resource settings

Natale A, Ronat JB, Mazoyer A, Rochard A, Boillot B,  et al.
2020-06-01 • Lancet Microbe
2020-06-01 • Lancet Microbe
Journal Article
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Commentary

Antibiotic resistance in conflict settings: lessons learned in the Middle East

Kanapathipillai R, Malou N, Hopman J, Bowman C, Yousef N,  et al.
2019-04-10 • Journal of Antimicrobial Chemotherapy
2019-04-10 • Journal of Antimicrobial Chemotherapy
Médecins Sans Frontières (MSF) has designed context-adapted antibiotic resistance (ABR) responses in countries across the Middle East. There, some health systems have been severely damag...
Journal Article
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Commentary

Clinical bacteriology in low-resource settings: today's solutions

Ombelet S, Ronat JB, Walsh T, Yansouni CP, Cox J,  et al.
2018-03-05 • Lancet Infectious Diseases
2018-03-05 • Lancet Infectious Diseases
Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference laborat...
Mini-Lab—MSF's simplified bacteriology laboratory for low-resource settings

Mini-Lab—MSF's simplified bacteriology laboratory for low-resource settings