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Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor WRJ, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J, Amambua AN, Affara M, Nwakanma D, Van Geertruyden JP, Mavoko M, Lutumba P, Matangila J, Brasseur P, Piola P, Randremanana R, Lasry E, Fanello CI, Onyamboko MA, Schramm B, Yah Z, Jones JJ, Fairhurst RM, Diakite M, Malenga G, Molyneux M, Rwangacondo C, Obonyo C, Gadisa E, Aseffa A, Loolpapit M, Henry MJ, Dorsey G, John C, Sirima SB, Barnes KI, Kremsner PG, Day NPJ, White NJ, Mukaka M
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Abstract
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.

Subject Area

malaria

Languages

English
DOI
10.1186/s12916-017-0990-6
Published Date
18 Jan 2018
PubMed ID
29347975
Journal
BMC Medicine
Volume | Issue | Pages
Volume 16, Issue 1
Issue Date
2018-01-18
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