Journal Article
|ResearchSingle low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa
Taylor WRJ, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J, Amambua AN, Affara M, Nwakanma D, Van Geertruyden JP, Mavoko M, Lutumba P, Matangila J, Brasseur P, Piola P, Randremanana R, Lasry E, Fanello CI, Onyamboko MA, Schramm B, Yah Z, Jones JJ, Fairhurst RM, Diakite M, Malenga G, Molyneux M, Rwangacondo C, Obonyo C, Gadisa E, Aseffa A, Loolpapit M, Henry MJ, Dorsey G, John C, Sirima SB, Barnes KI, Kremsner PG, Day NPJ, White NJ, Mukaka M
Abstract
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.
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