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Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013 | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Risk factors for measles mortality and the importance of decentralized case management during an unusually large measles epidemic in eastern Democratic Republic of Congo in 2013

Gignoux EM, Polonsky JA, Ciglenecki I, Bichet M, Coldiron ME, Thuambe Lwiyo E, Akonda I, Serafini M, Porten K
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Abstract
In 2013, a large measles epidemic occurred in the Aketi Health Zone of the Democratic Republic of Congo. We conducted a two-stage, retrospective cluster survey to estimate the attack rate, the case fatality rate, and the measles-specific mortality rate during the epidemic. 1424 households containing 7880 individuals were included. The estimated attack rate was 14.0%, (35.0% among children aged <5 years). The estimated case fatality rate was 4.2% (6.1% among children aged <5 years). Spatial analysis and linear regression showed that younger children, those who did not receive care, and those living farther away from Aketi Hospital early in the epidemic had a higher risk of measles related death. Vaccination coverage prior to the outbreak was low (76%), and a delayed reactive vaccination campaign contributed to the high attack rate. We provide evidences suggesting that a comprehensive case management approach reduced measles fatality during this epidemic in rural, inaccessible resource-poor setting.

Countries

Democratic Republic of Congo

Subject Area

measlesoutbreaks

Languages

English
DOI
10.1371/journal.pone.0194276
Published Date
14 Mar 2018
PubMed ID
29538437
Journal
PLOS One
Volume | Issue | Pages
Volume 13, Issue 3
Issue Date
2018-03-14
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