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Journal Article
|Research

Ebola Virus Disease: An Update On Current Prevention and Management Strategies

Trad MA, Naughton W, Yeung A, Mazlin L, O’sullivan M, Gilroy N, Fisher DA, Stuart RL
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Abstract
Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.

Subject Area

Ebola

Languages

English
DOI
10.1016/j.jcv.2016.11.005
Published Date
11 Nov 2016
PubMed ID
27893999
Journal
Journal of Clinical Virology
Volume | Issue | Pages
Volume 86
Issue Date
2017-01-01
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Ebola Virus Disease: An Update On Current Prevention and Management Strategies | Journal Article / Research | MSF Science Portal