logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5145.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5145.produseast1
Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults

Furin J, Alirol E, Allen E, Fielding K, Merle CS, Abubakar I, Andersen J, Davies G, Dheda K, Diacon A, Dooley KE, Dravnice G, Eisenach K, Everitt D, Ferstenberg D, Goolam-Mahomed A, Grobusch MP, Gupta RS, Harausz EP, Harrington M, Horsburgh Jr CR, Lienhardt C, McNeeley D, Mitnick CD, Nachman S, Nahid P, Nunn AJ, Phillips PPJ, Rodriguez CA, Shah SK, Wells C, Nyang'wa BT, du Cros PAK
Download

Similar Content
Loading...
Loading...
Loading...
Abstract
Drug-resistant tuberculosis (DR-TB) is a growing public health problem, and for the first time in decades, new drugs for the treatment of this disease have been developed. These new drugs have prompted strengthened efforts in DR-TB clinical trials research, and there are now multiple ongoing and planned DR-TB clinical trials. To facilitate comparability and maximise policy impact, a common set of core research definitions is needed, and this paper presents a core set of efficacy and safety definitions as well as other important considerations in DR-TB clinical trials work. To elaborate these definitions, a search of clinical trials registries, published manuscripts and conference proceedings was undertaken to identify groups conducting trials of new regimens for the treatment of DR-TB. Individuals from these groups developed the core set of definitions presented here. Further work is needed to validate and assess the utility of these definitions but they represent an important first step to ensure there is comparability in clinical trials on multidrug-resistant TB.

Subject Area

antibiotic resistancetuberculosisantimicrobial resistance

Languages

English
DOI
10.5588/ijtld.15.0490
Published Date
01 Mar 2016
PubMed ID
27046707
Journal
International Journal of Tuberculosis and Lung Disease
Volume | Issue | Pages
Volume 20, Issue 3, Pages 290-294
Dimensions Badge