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Journal Article
|Case Report/Series

Bedaquiline overdose: A case report

Telnov O, Alvarez V, Gragila E, Molfino L, du Cros PAK, Rich ML
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Bedaquiline overdose: A case report | Journal Article / Case Report/Series | MSF Science Portal
Abstract
We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm. Toxic effects at this dosage were therefore not observed.

Countries

Mozambique

Subject Area

antibiotic resistancetuberculosisantimicrobial resistance

Languages

English
DOI
10.1016/j.ijid.2019.03.035
Published Date
02 Apr 2019
PubMed ID
30951878
Journal
International Journal of Infectious Diseases
Volume | Issue | Pages
Volume 84, Pages 138-140
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