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Household drug-resistant TB contact tracing in Tajikistan | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Household drug-resistant TB contact tracing in Tajikistan

Rekart ML, Aung A, Cullip T, Mulanda WK, Mun L, Pirmahmadzoda B, Kliescokova J, Achar J, Alvarez JL, Sitali N, Sinha A
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Abstract
BACKGROUND
Tajikistan has a high burden of rifampicin-resistant TB (RR-TB), with 2,700 new cases estimated for 2021 (28/100,000 population). TB is spread among household members through close interaction and children exposed through household contact progress to disease rapidly and frequently.

METHODS
We retrospectively analysed programmatic data from household contact tracing in Dushanbe over 50 months. We calculated person-years of follow-up, contact tracing yield, number needed to screen (NNS) and number needed to test (NNT) to find one new case, and time to diagnosis.

RESULTS
We screened 6,654 household contacts of 830 RR-TB index cases; 47 new RR-TB cases were detected, 43 in Year 1 and 4 in Years 2 or 3. Ten were aged <5 years; 46/47 had TB symptoms, 34/45 had chest radiographs consistent with TB, 11/35 were Xpert Ultra-positive, 29/32 were tuberculin skin test-positive and 28/47 had positive TB culture and phenotypic drug susceptibility results. The NNS to find one RR-TB case was 141.57 and the NNT was 34.49. The yields for different types of contacts were as follows: 0.7% for screened contacts, 2.9% for tested contacts, 17.0% for symptomatic contacts and 12.1% for symptomatic contacts aged below 5 years.

CONCLUSION
RR-TB household contact tracing was feasible and productive in Tajikistan, a low middle-income country with an inefficient healthcare delivery system.

Countries

Tajikistan

Subject Area

antibiotic resistancetuberculosisantimicrobial resistance

Languages

English
DOI
10.5588/ijtld.23.0066
Published Date
01 Oct 2023
PubMed ID
37749832
Journal
International Journal of Tuberculosis and Lung Disease
Volume | Issue | Pages
Volume 27, Issue 10, Pages 748-753
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