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Showing 1 - 20 of 23 Items
Showing 1 - 20 of 23 Items
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Conference Material
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Abstract

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a new tool for disease elimination

Baudin E, Mordt OV, Alves D, Seixas J, Lemerani M,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
Trypanosoma brucei rhodesiense human African trypanosomiasis (r-HAT), the zoonotic, acute form of sleeping sickness in eastern Africa, is lethal if untreated. Today, onl...
Conference Material
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Video

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a new tool for disease elimination

Baudin E
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Slide Presentation

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense a new tool for disease elimination

Baudin E, Mordt OV, Alves D, Seixas J, Lemerani M,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Journal Article
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Editorial

Therapeutic strategies against leishmania and trypanosoma

Santos ALS, Rodrigues IA, d’Avila-Levy CM, Sodré CL, Ritmeijer KKD,  et al.
2023-10-19 • Pathogens
2023-10-19 • Pathogens
Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (als...
Journal Article
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Research

Human African trypanosomiasis amongst urban residents in Kinshasa: a case-control study

Robays J, Ebeja Kadima A, Lutumba P, Miaka mia Bilenge C, Kande Betu Ku Mesu V,  et al.
2004-08-01 • Tropical Medicine and International Health
2004-08-01 • Tropical Medicine and International Health
BACKGROUND: Increasing numbers of human African trypanosomiasis (HAT) cases have been reported in urban residents of Kinshasa, Democratic Republic Congo since 1996. We set up a case-cont...
Journal Article
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Short Report

Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis

Checchi F, Funk S, Chandramohan D, Haydon DT, Chappuis F
2015-07-04 • BMC Research Notes
2015-07-04 • BMC Research Notes
BACKGROUND
The duration of the stages of HAT is an important factor in epidemiological studies and intervention planning. Previously, we published estimates of the duration of the ha...
Conference Material
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Slide Presentation

Identifying high-risk villages to screen for human African trypanosomiasis in Maniema, Democratic Republic of Congo: findings from an active screening campaign

Beko P, Woudenberg T
2020-05-13 • MSF Scientific Days International 2020
2020-05-13 • MSF Scientific Days International 2020
Journal Article
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Research

In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness

Schmid C, Kuemmerle A, Blum J, Ghabri S, Kande V,  et al.
2012-11-29 • PLOS Neglected Tropical Diseases
2012-11-29 • PLOS Neglected Tropical Diseases
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to us...
Journal Article
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Research

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

Burri C, Yeramian PD, Allen JL, Merolle A, Serge KK,  et al.
2016-02-16 • PLOS Neglected Tropical Diseases
2016-02-16 • PLOS Neglected Tropical Diseases
BACKGROUND
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several ye...
Journal Article
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Commentary

Human african trypanosomiasis in the democratic republic of the congo: a looming emergency?

Hasker E, Lutumba P, Chappuis F, Kande V, Potet J,  et al.
2012-12-13 • PLOS Neglected Tropical Diseases
2012-12-13 • PLOS Neglected Tropical Diseases
Conference Material
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Video

Identifying high-risk villages to screen for human African trypanosomiasis in Maniema, Democratic Republic of Congo: findings from an active screening campaign

Beko P, Woudenberg T
2020-05-26 • MSF Scientific Days International 2020
2020-05-26 • MSF Scientific Days International 2020
Journal Article
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Commentary

NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

Yun O, Priotto G, Tong J, Flevaud L, Chappuis F
2010-05-25 • PLOS Neglected Tropical Diseases
2010-05-25 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo

Tong J, Valverde O, Mahoudeau C, Yun O, Chappuis F
2011-05-26 • Conflict and Health
2011-05-26 • Conflict and Health
Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often...
Journal Article
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Research

Integration of traditional healers in Human African Trypanosomiasis case finding in Central Africa: a quasi-experimental study

Kwedi Nolna S, Ntone R, Fouda Mbarga N, Mbainda S, Mutangala W,  et al.
2020-11-17 • Tropical Medicine and Infectious Disease
2020-11-17 • Tropical Medicine and Infectious Disease
BACKGROUND
Based on the premise that Africans in rural areas seek health care from traditional healers, this study investigated a collaborative model between traditional healers and...
Journal Article
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Short Report

Human African trypanosomiasis in areas without surveillance

Chappuis F, Lima MA, Flevaud L, Ritmeijer KKD
2010-02-01 • Emerging Infectious Diseases
2010-02-01 • Emerging Infectious Diseases
Journal Article
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Commentary

Human African trypanosomiasis

Brun R, Blum J, Chappuis F, Burri C
2009-10-14 • Lancet
2009-10-14 • Lancet
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases a...
Journal Article
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Commentary

Human African trypanosomiasis [review]

Brun R, Blum J, Chappuis F, Burri C
2010-01-09 • Lancet
2010-01-09 • Lancet
Journal Article
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Research

Nifurtimox-eflornithine combination therapy for second-stage Gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo

Alirol E, Schrumpf D, Amici Heradi J, Riedel A, de Patoul C,  et al.
2013-01-01 • Clinical Infectious Diseases
2013-01-01 • Clinical Infectious Diseases
BACKGROUND
Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of nifurtimox-eflornithine combination therapy (NECT) h...
Journal Article
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Review

Sleeping sickness

Malvy D, Chappuis F
2011-04-04 • Clinical Microbiology and Infection
2011-04-04 • Clinical Microbiology and Infection
Human African trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease that flourishes in impoverished, rural parts of sub-Saharan Africa. It is caused by infection with th...
Journal Article
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Research

Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis

Checchi F, Chappuis F, Karunakara U, Priotto G, Chandramohan D
2011-07-05 • PLOS Neglected Tropical Diseases
2011-07-05 • PLOS Neglected Tropical Diseases
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and...