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Showing 1 - 14 of 14 Items
Showing 1 - 14 of 14 Items
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Research

Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis—experiences from Armenia

Ardizzoni E, Mulders W, De Diego Fuertes M, Hayrapetyan A, Mirzoyan A,  et al.
2025-04-09 • Antimicrobial Agents and Chemotherapy
2025-04-09 • Antimicrobial Agents and Chemotherapy

Risk factors for baseline bedaquiline (BDQ) resistance, amplification during treatment, and correlations with treatment outcomes are not fully understood. This cohort included Armenia...

Journal Article
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Research
Journal Article
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Letter

Reduced critical concentration might not have improved MGIT-based DST’s sensitivity to rifampicin

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Research
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Research
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Research
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Short Report

How much should we still worry about QTc prolongation in rifampicin-resistant tuberculosis? ECG findings from TB-PRACTECAL clinical trial

Motta I, Cusinato M, Ludman AJ, Lachenal N, Dodd M,  et al.
2024-06-06 • Antimicrobial Agents and Chemotherapy
2024-06-06 • Antimicrobial Agents and Chemotherapy
Regimens for the treatment of rifampicin-resistant tuberculosis currently rely on the use of QT-prolonging agents. Using data from the randomized controlled trial, TB-PRACTECAL, we inves...
Rupasinghe P, 
Ashraf A, 
Barreda N, 
Parveen S, 
Zubair M, 
et al.
2024-05-02 • Antimicrobial Agents and Chemotherapy
2024-05-02 • Antimicrobial Agents and Chemotherapy

Rifampicin mono-resistant tuberculosis is not the same as multidrug-resistant tuberculosis: a descriptive study from Khayelitsha, South Africa

Salaam-Dreyer Z, Streicher EM, Sirgel FA, Menardo F, Borrell S,  et al.
2021-08-30 • Antimicrobial Agents and Chemotherapy
2021-08-30 • Antimicrobial Agents and Chemotherapy
Rifampicin mono-resistant TB (RMR-TB, rifampicin resistance and isoniazid susceptibility) constitutes 38% of all rifampicin-resistant TB (RR-TB) in South Africa and is increasing. We aim...

Pharmacokinetics of rifampin and isoniazid in tuberculosis-HIV-coinfected patients receiving nevirapine- or efavirenz-based antiretroviral treatment

Bhatt NB, Barau C, Amin A, Baudin E, Meggi B,  et al.
2014-03-24 • Antimicrobial Agents and Chemotherapy
2014-03-24 • Antimicrobial Agents and Chemotherapy
This is a substudy of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patien...

Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment

Feuerriegel S, Cox HS, Zarkua N, Karimovich HA, Braker K,  et al.
2009-05-26 • Antimicrobial Agents and Chemotherapy
2009-05-26 • Antimicrobial Agents and Chemotherapy
The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is crucial for the institution of appropriate treatment regimens as early as possible. Although ...

Real-Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates

Parrado R, Ramirez JC, de la Barra A, Alonso-Vega C, Juiz N,  et al.
2018-12-03 • Antimicrobial Agents and Chemotherapy
2018-12-03 • Antimicrobial Agents and Chemotherapy
This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time PCR (qPCR) for baseline detection and quantification of parasitic loads and post-trea...

Rifampicin-monoresistant tuberculosis is not the same as multidrug-resistant tuberculosis: a descriptive study from Khayelitsha, South Africa

Salaam-Dreyer Z, Streicher EM, Sirgel FA, Menardo F, Borrell S,  et al.
2021-10-18 • Antimicrobial Agents and Chemotherapy
2021-10-18 • Antimicrobial Agents and Chemotherapy
Rifampin monoresistance (RMR; rifampin resistance and isoniazid susceptibility) accounts for 38% of all rifampin-resistant tuberculosis (RR-TB) in South Africa and is increasing. We aime...

Methodological issues in the assessment of antimalarial drug treatment: Analysis of 13 studies in eight African countries from 2001 to 2004

Guthmann JP, Pinoges LLP, Checchi F, Cousens S, Balkan S,  et al.
2006-11-01 • Antimicrobial Agents and Chemotherapy
2006-11-01 • Antimicrobial Agents and Chemotherapy
The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy ...

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L,  et al.
2008-03-01 • Antimicrobial Agents and Chemotherapy
2008-03-01 • Antimicrobial Agents and Chemotherapy
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-pi...

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine and quinine in pregnant women with uncomplicated falciparum malaria in Uganda

Tarning J, Kloprogge F, Dhorda M, Jullien V, Nosten F,  et al.
2013-08-05 • Antimicrobial Agents and Chemotherapy
2013-08-05 • Antimicrobial Agents and Chemotherapy
ABSTRACTPregnancy alters the pharmacokinetic properties of many drugs used in the treatment of malaria, usually resulting in lower drug exposures. This i...

Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from mycobacterium fortuitum

Aínsa J, Martin C, Gicquel B, Gomez-Lus R
1996-10-01 • Antimicrobial Agents and Chemotherapy
1996-10-01 • Antimicrobial Agents and Chemotherapy
A novel gene encoding an aminoglycoside 2'-N-acetyltransferase (AAC) was cloned from Mycobacterium fortuitum. DNA sequencing results identified an open reading frame that we have called ...

High mortality among older patients treated with pentavalent antimonials for visceral leishmaniasis in East Africa and rationale for switch to liposomal amphotericin B

Chappuis F, Alirol E, Worku DT, Mueller YK, Ritmeijer KKD
2011-01-01 • Antimicrobial Agents and Chemotherapy
2011-01-01 • Antimicrobial Agents and Chemotherapy
Visceral leishmaniasis (VL; kala azar), a fatal disease if left untreated, is one of the most neglected tropical diseases....