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Showing 1 - 20 of 59 Items
Showing 1 - 20 of 59 Items
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Journal Article
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Research

Prediction of visceral leishmaniasis development in a highly exposed HIV cohort in Ethiopia based on Leishmania infection markers: results from the PreLeisH study

van Griensven J, van Henten S, Kibret A, Kassa M, Beyene H,  et al.
2024-12-01 • EBioMedicine
2024-12-01 • EBioMedicine

BACKGROUND

Tar...

Journal Article
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Research

A preliminary indication that HLA-A*03:01 may be associated with visceral leishmaniasis development in people living with HIV in Ethiopia

de Vrij N, Vandoren R, Ramadan K, Van Hul A, Ceulemans A,  et al.
2024-09-30 • PLOS Neglected Tropical Diseases
2024-09-30 • PLOS Neglected Tropical Diseases

Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. V...

Journal Article
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Research

Chronic high-level parasitemia in HIV-infected individuals with or without visceral leishmaniasis in an endemic area in Northwest Ethiopia: Potential superspreaders?

van Griensven J, van Henten S, Kibret A, Kassa M, Beyene H,  et al.
2024-07-19 • Clinical Infectious Diseases
2024-07-19 • Clinical Infectious Diseases

Background

People with human immunodeficiency virus (PWH) with recurrent visceral leishmaniasis (VL) could potentially drive Leishmania transmission in areas wi...

Journal Article
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Research

Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients

de Vrij N, Pollmann J, Rezende AM, Ibarra-Meneses AV, Pham TT,  et al.
2024-05-03 • Communications Biology
2024-05-03 • Communications Biology
A large proportion of HIV-coinfected visceral leishmaniasis (VL-HIV) patients exhibit chronic disease with frequent VL recurrence. However, knowledge on immunological determinants underl...
Journal Article
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Pre-Print

HLA-A*03:01 is associated with visceral leishmaniasis development in people living with HIV in Ethiopia

de Vrij N, Vandoren R, Ramadan K, Van Hul A, Kassa M,  et al.
2024-02-18 • medRxiv
2024-02-18 • medRxiv
Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. VL-H...
Journal Article
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Case Report/Series

Chronic high level parasitemia in HIV-infected individuals with or without visceral leishmaniasis in an endemic area in North-West Ethiopia: potential superspreaders?

van Griensven J, van Henten S, Kibret A, Kassa M, Beyene H,  et al.
2024-01-09 • Clinical Infectious Diseases
2024-01-09 • Clinical Infectious Diseases
BACKGROUND
HIV patients with recurrent visceral leishmaniasis (VL) could potentially drive Leishmania transmission in areas with anthroponotic transmission such as East-Africa, but s...
Journal Article
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Review

The status of combination therapy for visceral leishmaniasis: an updated review

van Griensven J, Dorlo TPC, Diro EGJ, Costa CH, Burza S
2024-01-01 • Lancet Infectious Diseases
2024-01-01 • Lancet Infectious Diseases
For the past 15 years, trials of combination therapy options for visceral leishmaniasis have been conducted with the aim of identifying effective, and safe treatment regimens that were s...
Journal Article
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Commentary

Anticipating visceral leishmaniasis epidemics due to the conflict in Northern Ethiopia

Boodman C, van Griensven J, Gupta N, Diro EGJ, Ritmeijer KKD
2023-03-23 • PLOS Neglected Tropical Diseases
2023-03-23 • PLOS Neglected Tropical Diseases
Journal Article
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Research

High prevalence of lipoatrophy among patients on stavudine-containing first-line antiretroviral therapy regimens in Rwanda

van Griensven J, De Naeyer L, Mushi T, Ubarijoro S, Gashumba D,  et al.
2007-08-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2007-08-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
This study was conducted among individuals placed on WHO-recommended first-line antiretroviral therapy (ART) at two urban health centres in Kigali, Rwanda, in order to determine (a) the ...
Journal Article
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Research

Development and external validation of a clinical prognostic score for death in visceral leishmaniasis patients in a high HIV co-infection burden area in Ethiopia

Abongomera C, Ritmeijer KKD, Vogt F, Buyze J, Mekonnen Z,  et al.
2017-06-05 • PLOS One
2017-06-05 • PLOS One
BACKGROUND
In Ethiopia, case fatality rates among subgroups of visceral leishmaniasis (VL) patients are high. A clinical prognostic score for death in VL patients could contribute to...
Journal Article
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Research

Visceral leishmaniasis and HIV co-infection in Bihar, India: long-term effectiveness and treatment outcomes with liposomal amphotericin B (AmBisome)

Burza S, Mahajan R, Singh A, van Griensven J, Pandey K,  et al.
2014-08-07 • PLOS Neglected Tropical Diseases
2014-08-07 • PLOS Neglected Tropical Diseases
Visceral Leishmaniasis (VL; also known as kala-azar) is an ultimately fatal disease endemic in the Indian state of Bihar, while HIV/AIDS is an emerging disease in this region. A 2011 obs...
Journal Article
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Research

Mortality among PCR negative admitted Ebola suspects during the 2014/15 outbreak in Conakry, Guinea: A retrospective cohort study

Ingelbeen B, Bah EI, Decroo T, Balde I, Nordenstedt H,  et al.
2017-06-30 • PLOS One
2017-06-30 • PLOS One
Non-cases are suspect Ebola Virus Disease (EVD) cases testing negative by EVD RT-PCR after admission to an Ebola Treatment Centre (ETC). Admitting non-cases to an ETC prompts concerns on...
Journal Article
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Commentary

Open access for operational research publications from low- and middle-income countries: who pays?

Zachariah R, Kumar AMV, Reid A, Van der Bergh R, Isaakidis P,  et al.
2014-09-21 • Public Health Action
2014-09-21 • Public Health Action
Journal Article
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Research

Visceral leishmaniasis and HIV coinfection in East Africa

Diro EGJ, Lynen L, Ritmeijer KKD, Boelaert M, Hailu ADE,  et al.
2014-06-26 • PLOS Neglected Tropical Diseases
2014-06-26 • PLOS Neglected Tropical Diseases
Visceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload a...
Journal Article
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Research

Weight loss after the first year of stavudine-containing antiretroviral therapy and its association with lipoatrophy, virological failure, adherence and CD4 counts at primary health care level in Kigali, Rwanda

van Griensven J, Zachariah R, Mugabo J, Reid AJ
2010-12-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2010-12-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
This study was conducted among 609 adults on stavudine-based antiretroviral treatment (ART) for at least one year at health center level in Kigali, Rwanda to (a) determine the proportion...
Journal Article
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Commentary

The use of Ebola convalescent plasma to treat Ebola Virus Disease in resource constrained settings: a perspective from the field

van Griensven J, De Weiggheleire A, Delamou A, Smith PJ, Edwards T,  et al.
2015-08-10 • Clinical Infectious Diseases
2015-08-10 • Clinical Infectious Diseases
The clinical evaluation of convalescent plasma (CP) for the treatment of Ebola Virus Disease (EVD) in the current outbreak, predominantly affecting Guinea, Sierra Leone and Liberia, was ...
Journal Article
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Research

The initial effectiveness of liposomal amphotericin B (AmBisome) and miltefosine combination for treatment of visceral leishmaniasis in HIV co-infected patients in Ethiopia: A retrospective cohort study

Abongomera C, Diro EGJ, de Lima Pereira A, Buyze J, Stille K,  et al.
2018-05-25 • PLOS Neglected Tropical Diseases
2018-05-25 • PLOS Neglected Tropical Diseases
North-west Ethiopia faces the highest burden world-wide of visceral leishmaniasis (VL) and HIV co-infection. VL-HIV co-infected patients have higher (initial) parasitological failure and...
Journal Article
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Research

Malaria profiles and challenges in artemisinin resistance containment in Myanmar

Nwe TW, Oo T, Wai KT, Zhou SS, van Griensven J,  et al.
2017-04-25 • Infectious Diseases of Poverty
2017-04-25 • Infectious Diseases of Poverty
BACKGROUND
This study examined evolving malaria profiles from January, 2010 to December, 2014 to evaluate achievements and challenges of implementing measures to prevent and control ...
Journal Article
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Commentary

Oops, what about ethics?

Oladimeji O, Isaakidis P, Zachariah R, Hinderaker SG, Koghali M,  et al.
2013-09-21 • Public Health Action
2013-09-21 • Public Health Action
Ethics approval of research studies is essential for the protection and rights of study subjects, whether this is for prospective research or record reviews. This article shares a painfu...
Journal Article
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Research

Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015

van Griensven J, Bah EI, Haba N, Delamou A, Camara BS,  et al.
2016-12-01 • Emerging Infectious Diseases
2016-12-01 • Emerging Infectious Diseases
By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predic...