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Clinical best practices for caring for people with expanded resistance to newer TB drugs

Nkomo T, Udwadia Z, Vambe D, van Rie A, Thi S, et al.

2025-06-13 • IJTLD OPEN

BACKGROUND

Strains of Mycobacterium tuberculosis

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Operational aspects of bedaquiline implementation in Swaziland: report from the field

Vambe D, Dlamini T, Furin J, Gracia-Edwards C, Keus K, et al.

2017-09-21 • Public Health Action

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Short Report

Operational aspects of bedaquiline implementation in Swaziland: report from the field

Vambe D, Dlamini T, Furin J, Gracia-Edwards C, Keus K, et al.

2017-09-21 • Public Health Action

Understanding the role of video direct observed therapy for patients on an oral short-course regimen for multi-drug resistant tuberculosis: findings from a qualitative study in Eswatini

Mukooza E, Schausberger B, Mmema N, Dlamini V, Aung A, et al.

2024-08-15 • BMC Infectious Diseases

BACKGROUND

Improving treatment success rates among multi drug-resistant tuberculosis (MDR-TB) patients is critical to reducing its incidence and mortality, but adherence poses a...

The introduction of video-enabled directly observed therapy (video-DOT) for patients with drug-resistant TB disease in Eswatini amid the COVID-19 pandemic: a retrospective cohort study

Kerschberger B, Daka M, Shongwe B, Dlamini T, Ngwenya S, et al.

2024-06-03 • BMC Health Services Research

BACKGROUND

Video-enabled directly observed therapy (video-DOT) has been proposed as an additional option for&nb...

Sustained high fatality during TB therapy amid rapid decline in TB mortality at population level: A retrospective cohort and ecological analysis from Shiselweni, Eswatini

Kerschberger B, Vambe D, Schomaker M, Mabhena E, Daka M, et al.

2024-03-01 • Tropical Medicine and International Health

OBJECTIVES
Despite declining TB notifications in Southern Africa, TB‐related deaths remain high. We describe patient‐ and population‐level trends in TB‐related deaths in Eswatini ove...

The introduction of video-enabled directly observed therapy (video-DOT) for patients with drug-resistant TB disease in Eswatini amid the COVID-19 pandemic – a retrospective cohort study

Kerschberger B, Daka M, Shongwe B, Dlamini T, Ngwenya SM, et al.

2023-08-09 • BMC Health Services Research

BACKGROUND
Video-enabled directly observed therapy (video-DOT) has been proposed as an additional option for treatment provision besides in-person DOT for patients with drug-resistan...

"We have to learn to cooperate with each other": a qualitative study to explore integration of traditional healers into the provision of HIV self-testing and tuberculosis screening in Eswatini

Schausberger B, Mmema N, Dlamini V, Dube L, Aung A, et al.

2021-12-06 • BMC Health Services Research

BACKGROUND
Traditional healing plays an important role in healthcare in Eswatini, and innovative collaborations with traditional healers may enable hard-to-reach men to access HIV an...

Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB

Cox V, McKenna L, Acquah R, Reuter A, Wasserman S, et al.

2020-11-01 • International Journal of Tuberculosis and Lung Disease

Rapid diagnostics, newer drugs, repurposed medications, and shorter regimens have radically altered the landscape for treating rifampicin-resistant TB (RR-TB) and multidrug-resistant TB ...

Video/Virtually Observed Therapy for patients with drug-resistant tuberculosis in Eswatini: a rapid response to COVID-19 lockdown measures

Aung A, Daka M, Tamrat A, Gwitima T, Chidhuro T, et al.

2021-05-20 • MSF Scientific Days International 2021: Innovation

WHAT CHALLENGE OR OPPORTUNITY DID YOU TRY TO ADDRESS? WERE EXISTING SOLUTIONS NOT AVAILABLE OR NOT GOOD ENOUGH?
The COVID-19 pandemic has prompted lockdown measures in many places, b...

Successful expansion of community-based drug-resistant TB care in rural Eswatini - a retrospective cohort study

Kerschberger B, Telnov A, Yano N, Cox HS, Zabsonre I, et al.

2019-10-01 • Tropical Medicine and International Health

OBJECTIVES
Provision of drug-resistant tuberculosis (DR-TB) treatment is scarce in resource-limited settings. We assessed the feasibility of ambulatory DR-TB care for treatment expan...

Decreased risk of HIV-associated TB during antiretroviral therapy expansion in rural Eswatini from 2009 to 2016: a cohort and population-based analysis

Kerschberger B, Schomaker M, Telnov A, Vambe D, Kisyeri N, et al.

2019-09-19 • Tropical Medicine and International Health

OBJECTIVES
This paper assesses patient- and population-level trends in TB notifications during rapid expansion of antiretroviral therapy in Eswatini which has an extremely high incid...

Bedaquiline and delamanid result in low rates of unfavourable outcomes among TB patients in Eswatini

Vambe D, Kay AW, Furin J, Howard AA, Dlamini T, et al.

2020-10-01 • International Journal of Tuberculosis and Lung Disease

SETTING: Since 2015, Eswatini has been scaling up bedaquiline (BDQ) and delamanid (DLM) based drug-resistant TB treatment regimens under programmatic conditions.

OBJECTIVE: Id...

Model of care and risk factors for poor outcomes in patients on multi-drug resistant tuberculosis treatment at two facilities in Eswatini (formerly Swaziland), 2011–2013

Verdecchia M, Keus K, Blankley S, Vambe D, Ssonko C, et al.

2018-10-17 • PLOS One

INTRODUCTION
Since 2011 Médecins sans Frontières together with the eSwatini Ministry of Health have been managing patients with multi-drug resistant tuberculosis (MDR-TB) at Matsapha...

'She is like my mother': Community-based care of drug-resistant tuberculosis in rural Eswatini

Burtscher D, Bjertrup PJ, Vambe D, Dlamini V, Mmema N, et al.

2020-08-20 • Global Public Health

Patients with drug-resistant tuberculosis (DR-TB) have received community-based care in Eswatini since 2009. Trained and compensated community treatment supporters (CTSs) provide directl...

2017-09-21 • Public Health Action