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Showing 1 - 19 of 19 Items
Showing 1 - 19 of 19 Items
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Journal Article
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Review

Optimal dosing and duration of linezolid for the treatment of multidrug-resistant and rifampicin-resistant tuberculosis: An individual patient data meta-analysis

Kwak N, Kim JY, Han A, Berry C, Beumont M,  et al.
2025-07-17 • European Respiratory Journal
2025-07-17 • European Respiratory Journal

BACKGROUND

The optimal dosing strategy of linezolid for treating multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) remains unclear. We condu...

Journal Article
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Commentary
Journal Article
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Research
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Research
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Research
Journal Article
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Research

Expanding the use of dolutegravir-based antiretroviral therapy in multidrug-resistant TB

Murphy RA, 
Journal Article
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Research
Journal Article
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Commentary
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research

Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa

Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
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Research
Journal Article
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Research

Multidrug-resistant chronic osteomyelitis complicating war injury in Iraqi civilians

Murphy RA, Ronat JB, Fakri R, Herard P, Blackwell N,  et al.
Journal Article
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Research
Journal Article
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Letter

Challenging the barriers to accessing surgery in low-resource settings: Lessons learned from burns

Elder G, Murphy RA, Herard P, Dilworth K, Olson D,  et al.
2015-07-01 • Surgery
2015-07-01 • Surgery

Simplifying switch to second-line antiretroviral therapy in sub Saharan Africa: predicted effect of using a single viral load to define efavirenz-based first-line failure

Shroufi A, van Cutsem G, Cambiano V, Bansi-Matharu L, Duncan K,  et al.
2019-08-01 • AIDS
2019-08-01 • AIDS
BACKGROUND
Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan Africa never initiate second-line ART or do so after significant delay. For people on ART w...

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options

Singh A, Sunpath H, Green TN, Padayachi N, Hiramen K,  et al.
2011-11-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-11-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
BACKGROUND
Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isol...

Highly drug-resistant pathogens implicated in burn-associated bacteremia in an Iraqi burn care unit

Ronat JB, Kakol J, Khoury M, Yun O, Brown V,  et al.
2014-08-11 • PLOS One
2014-08-11 • PLOS One
In low- and middle-income countries, bloodstream infections are an important cause of mortality in patients with burns. Increasingly implicated in burn-associated infections are highly d...
Douglas-Jones B, 
Mucinya G, 
Sunpath H, 
Govender T
2021-09-01 • International Journal of Tuberculosis and Lung Disease
2021-09-01 • International Journal of Tuberculosis and Lung Disease
The wider availability of dolutegravir (DTG) containing HIV therapy for patients living with multidrug-resistant TB (MDR-TB) presents several advantages. DTG-based antiretroviral therapy...

Time to embrace access programmes for medicines: Lessons from the South African flucytosine access programme

Shroufi A, Govender NP, Meintjes GA, Black JM, Nel J,  et al.
2020-06-01 • International Journal of Infectious Diseases
2020-06-01 • International Journal of Infectious Diseases
BACKGROUND
Cryptococcal Meningitis (CM) is estimated to cause 181,000 deaths annually; with the majority occurring in Sub Saharan Africa. Flucytosine is recommended by the World Heal...

Introducing an antibiotic stewardship program in a humanitarian surgical hospital

Bhalla N, Hussein N, Atari M, Fakhri RM, Lepora C,  et al.
2016-11-01 • American Journal of Infection Control
2016-11-01 • American Journal of Infection Control
Antibiotic stewardship program (ASP) implementation in humanitarian settings is a new endeavor. Doctors Without Borders/Médecins Sans Frontières introduced an ASP within a hospital in Am...

Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection

Kemigisha E, Nanjebe D, Langendorf C, Aberrane S, Nyehangane D,  et al.
2018-10-09 • PLOS One
2018-10-09 • PLOS One
Acute central nervous system (CNS) infections in children in sub-Saharan Africa are often fatal. Potential contributors include late presentation, limited diagnostic capacity and inadequ...

Invasive infection and outcomes in a humanitarian surgical burn program in Haiti

Murphy RA, Nisenbaum L, Labar AS, Sheridan RL, Ronat JB,  et al.
2016-02-25 • World Journal of Surgery
2016-02-25 • World Journal of Surgery
BACKGROUND
Compared to high-income settings, survival in burn units in low-income settings is lower with invasive infections one leading cause of death. Médecins Sans Frontières is i...

Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings

Murphy RA, Gounder L, Manzini TC, Ramdial PK, Castilla C,  et al.
2015-03-30 • Open Forum Infectious Diseases
2015-03-30 • Open Forum Infectious Diseases
The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and t...
Murphy RA, 
France H, 
Sunpath H, 
Gordon ML, 
Marconi VC, 
et al.
2009-02-01 • Journal of Tropical Pediatrics
2009-02-01 • Journal of Tropical Pediatrics
The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antire...

Coadministration of lopinavir/ritonavir and rifampicin in HIV and tuberculosis co-infected adults in South Africa

Murphy RA, Marconi VC, Gandhi R, Kuritzkes DR, Sunpath H
2012-09-28 • PLOS One
2012-09-28 • PLOS One
In HIV-infected patients receiving rifampicin-based treatment for tuberculosis (TB), the dosage of lopinavir/ritonavir (LPV/r) is adjusted to prevent sub-therapeutic lopinavir concentrat...

Low uptake of antiretroviral therapy after admission with human immunodeficiency virus and tuberculosis in KwaZulu-Natal, South Africa

Murphy RA, Sunpath H, Taha B, Kappagoda S, Maphasa KT,  et al.
2010-07-01 • International Journal of Tuberculosis and Lung Disease
2010-07-01 • International Journal of Tuberculosis and Lung Disease
OBJECTIVES
A prospective cohort study was conducted among human immunodeficiency virus (HIV) infected in-patients with tuberculosis (TB) or other opportunistic infections (OIs) in So...

Multidrug-resistant surgical site infections in a humanitarian surgery project

Murphy RA, Okoli O, Essien I, Teicher CL, Elder G,  et al.
2016-08-11 • Epidemiology and Infection
2016-08-11 • Epidemiology and Infection
The epidemiology of surgical site infections (SSIs) in surgical programmes in sub-Saharan Africa is inadequately described. We reviewed deep and organ-space SSIs occurring within a traum...

Early warning indicators for first-line virologic failure independent of adherence measures in a South African urban clinic

Marconi VC, Wu B, Hampton J, Ordonez CE, Johnson BA,  et al.
2013-12-09 • AIDS Patient Care and STDs
2013-12-09 • AIDS Patient Care and STDs
Abstract We sought to develop individual-level Early Warning Indicators (EWI) of virologic failure (VF) for clinicians to use during routine care complementing WHO population-level EWI. ...
2011-07-01 • Journal of Trauma - Injury Infection and Critical Care
2011-07-01 • Journal of Trauma - Injury Infection and Critical Care
War-related orthopedic injury is frequently complicated by environmental contamination and delays in management, placing victims at increased risk for long-term infectious complications....

The emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City

Murphy RA
2008-06-01 • Clinical Infectious Diseases
2008-06-01 • Clinical Infectious Diseases
Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency viru...

HIV viral load algorithm

Shroufi A, Van Cutsem G, Cambiano V, Bansi-Matharu L, Duncan K,  et al.
2020-01-01 • AIDS
2020-01-01 • AIDS