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Journal Article
|Research

Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings

Murphy RA, Gounder L, Manzini TC, Ramdial PK, Castilla C, Moosa MY
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Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings | Journal Article / Research | MSF Science Portal
Abstract
The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.

Languages

English
DOI
10.1093/ofid/ofv025
Published Date
30 Mar 2015
PubMed ID
26034774
Journal
Open Forum Infectious Diseases
Volume | Issue | Pages
Volume 2, Issue 1
Issue Date
2015-01-01
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