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Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Van Anh DT,  et al.
2025-09-01 • Lancet Child and Adolescent Health
2025-09-01 • Lancet Child and Adolescent Health

BACKGROUND

Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activatio...

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Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • MSF Scientific Days International 2025
2025-02-05 • MSF Scientific Days International 2025

Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • MSF Scientific Days International 2025
2025-02-05 • MSF Scientific Days International 2025

Risk stratification of childhood infection using host markers of immune and endothelial activation: A multi-country prospective cohort study in Asia (Spot Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • medRxiv
2025-02-05 • medRxiv

BACKGROUND

Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in c...

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

Taylor WRJ, Hoglund RM, Peerawaranun P, Nguyen TN, Hien TT,  et al.
2021-09-09 • Malaria Journal
2021-09-09 • Malaria Journal
BACKGROUND
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed tar...

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Kloprogge F, Workman L, Borrmann S, Tekete M, Lefevre G,  et al.
2018-06-12 • PLOS Medicine
2018-06-12 • PLOS Medicine
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine...

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...

Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites

Anderson TJC, Nair SA, Sudimack D, Williams JT, Mayxay M,  et al.
2005-12-01 • Molecular Biology and Evolution
2005-12-01 • Molecular Biology and Evolution
Loci targeted by directional selection are expected to show elevated geographical population structure relative to neutral loci, and a flurry of recent papers have used this rationale to...

Prediction of disease severity in young children presenting with acute febrile illness in resource-limited settings: a protocol for a prospective observational study

Chandna A, Aderie EM, Ahmad R, Arguni E, Ashley EA,  et al.
2021-01-25 • BMJ Open
2021-01-25 • BMJ Open
INTRODUCTION
In rural and difficult-to-access settings, early and accurate recognition of febrile children at risk of progressing to serious illness could contribute to improved pati...

Selection strength and hitchhiking around two anti-malarial resistance genes

Nash D, Nair SA, Mayxay M, Newton PN, Guthmann JP,  et al.
2005-06-02 • Proceedings. Biological sciences / The Royal Society
2005-06-02 • Proceedings. Biological sciences / The Royal Society
Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is though...

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis

Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis FM,  et al.
2009-07-29 • PLOS One
2009-07-29 • PLOS One
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patien...

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant plasmodium falciparum distributions in Southeast Asia

Grist EP, Fleqq JA, Humphreys G, Mas IS, Anderson TJC,  et al.
2016-10-24 • International Journal of Health Geographics
2016-10-24 • International Journal of Health Geographics
BACKGROUND
Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their...

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Lee SJ, Stepniewska K, Anstey NM, Ashley EA, Barnes KI,  et al.
2008-08-01 • Malaria Journal
2008-08-01 • Malaria Journal
BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For compari...

In vivo parasitological measures of artemisinin susceptibility

Stepniewska K, Ashley EA, Lee SJ, Anstey NM, Barnes KI,  et al.
2010-02-15 • Journal of Infectious Diseases
2010-02-15 • Journal of Infectious Diseases
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of mal...

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Hossain MS, Commons RJ, Douglas NM, Thriemer KL, Alemayehu BH,  et al.
2020-11-19 • PLOS Medicine
2020-11-19 • PLOS Medicine
Background: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using a...