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Showing 1 - 6 of 6 Items
Showing 1 - 6 of 6 Items
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Journal Article
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Research

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Schilling WHK, Mukaka M, Callery JJ, Llewelyn MJ, Cruz CV,  et al.
2024-09-12 • PLOS Medicine
2024-09-12 • PLOS Medicine

BACKGROUND

Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety an...

Journal Article
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Research

Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar

Guthmann JP, Pittet A, Lesage A, Imwong M, Lindegardh N,  et al.
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar. METHODS: Enrolled patients at Sonsinphya clinic >6 m...
Journal Article
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Research

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JH,  et al.
2007-04-01 • Journal of Infectious Diseases
2007-04-01 • Journal of Infectious Diseases
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudesce...
Journal Article
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Research

Assessing the asymptomatic reservoir and dihydroartemisinin-piperaquine effectiveness in a low transmission setting threatened by artemisinin resistant Plasmodium falciparum

Falq G, Van der Bergh R, de Smet M, Etienne W, Nguon C,  et al.
2016-09-01 • Malaria Journal
2016-09-01 • Malaria Journal
BACKGROUND
In Cambodia, elimination of artemisinin resistance through direct elimination of the Plasmodium falciparum parasite may be the only strategy. Prevalence and incidence at d...
Journal Article
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Research

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

Smithuis FM, Kyaw MK, Phe O, Win T, Aung PP,  et al.
2010-10-01 • Lancet Infectious Diseases
2010-10-01 • Lancet Infectious Diseases
BACKGROUND: Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whe...
Journal Article
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Research

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant plasmodium falciparum distributions in Southeast Asia

Grist EP, Fleqq JA, Humphreys G, Mas IS, Anderson TJC,  et al.
2016-10-24 • International Journal of Health Geographics
2016-10-24 • International Journal of Health Geographics
BACKGROUND
Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their...