Search Results | MSF Science Portal

Journal Article

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Research

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M, et al.

2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

Journal Article

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Commentary

Vonasek BJ, Marcy O, Armour J, Casenghi M, Cazes C, et al.

2025-03-23 • Lancet Child and Adolescent Health

Each day more than 500 children younger than 15 years die from tuberculosis. Considerable progress has been...

Journal Article

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Research

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R, et al.

2025-02-01 • Lancet Child and Adolescent Health

BACKGROUND

There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially ...

Journal Article

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Research

Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, et al.

2024-12-19 • Lancet Microbe

BACKGROUND

Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the p...

Journal Article

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Research

Khan U, Rich M, Franke M, Lachenal N, Ahmed S, et al.

2024-12-10 • Clinical Infectious Diseases

BACKGROUND

The 2022 WHO guidelines on multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) recommend six months of bedaquiline (Bdq) in the all-oral 9-month shorter regimen ...

Journal Article

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Short Report

Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, et al.

2024-07-01 • Lancet Global Health

Journal Article

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Research

Chihana M, Conan N, Ohler L, Huerga H, Wanjala S, et al.

2024-06-17 • Journal of the International Association of Providers of AIDS Care

BACKGROUND
The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...

Journal Article

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Research

Lightowler MS, Sander JV, García de Casasola Sánchez G, Mateos González M, Güerri-Fernández R, et al.

2024-06-02 • Journal of Clinical Medicine

BACKGROUND
During the COVID-19 pandemic and the burden on hospital resources, the rapid categorization of high-risk COVID-19 patients became essential, and lung ultrasound (LUS) emer...

Journal Article

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Research

Kho S, Seung KJ, Huerga H, Bastard M, Khan PY, et al.

2024-05-09 • Nature Communications

Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT032592...

Conference Material

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Poster

Abdullah MB, Issa-Soumana A-M, Namulwana ML, Barry I, Fidelle Nyikayo L, et al.

2024-05-03 • MSF Paediatric Days 2024

Conference Material

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Poster

Chara A, Abdullahi M, Ogundipe K, Briskin E, Phelan S, et al.

2024-05-03 • MSF Paediatric Days 2024

Journal Article

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Research

Sauer SM, Mitnick CD, Khan UT, Hewison CCH, Bastard M, et al.

2024-01-25 • Clinical Infectious Diseases

BACKGROUND
Quantification of recurrence risk following successful treatment is crucial to evaluating regimens for multidrug- or rifampicin-resistant (MDR/RR) tuberculosis (TB). Howev...

Journal Article

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Short Report

Lotia Farrukh I, Lachenal N, Adenov MM, Ahmed SM, Algozhin Y, et al.

2024-01-25 • Clinical Infectious Diseases

Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of ...

Journal Article

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Research

Zeng C, Hernán MA, Trevisi L, Sauer S, Mitnick CD, et al.

2024-01-20 • medRxiv

RATIONALE

Treatment outcomes may be compromised among patients with multidrug- or rifampicin-resistant tuberculosis with additional fluoroquinolone resis...

Journal Article

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Research

Huerga H, Farhat JB, Maman D, Conan N, Van Cutsem G, et al.

2023-12-22 • PLOS Global Public Health

Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcome...

Journal Article

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Research

Lissouba P, Rücker SCM, Otieno LA, Akatukwasa C, Xulu S, et al.

2023-11-30 • BMJ Open

OBJECTIVES
Evidence on the acceptability of urine-based assays for tuberculosis (TB) diagnosis among patients remains limited. We sought to describe patients’ experiences and percept...

Journal Article

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Research

Mhlanga L, Welte A, Grebe E, Ohler L, Van Cutsem G, et al.

2023-07-13 • IJID Regions

OBJECTIVE
We estimated changes in the HIV incidence from 2013 to 2018 in Eshowe/Mbongolwane, KwaZulu Natal, South Africa where Médecins Sans Frontières is engaged in providing HIV te...

Journal Article

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Research

Trevisi L, Hernán MA, Mitnick CD, Khan UT, Seung KJ, et al.

2023-06-01 • American Journal of Respiratory and Critical Care Medicine

RATIONALE
Current recommendations for the treatment of rifampin- and multidrug-resistant tuberculosis include bedaquiline used for six months or longer. Evidence is needed to inform ...

Journal Article

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Research

Rich ML, Khan UT, Zeng C, LaHood AN, Franke MF, et al.

2023-06-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
Evidence of the effectiveness of the WHO-recommended design of longer individualized regimens for multidrug- or rifampicin-resistant TB (MDR/RR-TB) is limited.

OB...

Journal Article

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Research

Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, et al.

2023-06-01 • Lancet Global Health

BACKGROUND
Sputum is the most widely used sample to diagnose active tuberculosis, but many people living with HIV are unable to produce sputum. Urine, in contrast, is readily availab...

Science Portal

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Leveraging nutritional rehabilitation and tuberculosis programmes to tackle tuberculosis and severe acute malnutrition in children

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data

The frequency and incidence of QT prolongation with extended use of bedaquiline or delamanid in a large, multi-country MDR/RR-TB cohort

Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests: rationale and guidance for future research

Changes over time in the proportion of advanced HIV disease in two high HIV prevalence settings in Ndhiwa (Kenya) and Eshowe (South Africa)

Evaluation of a lung ultrasound score in hospitalized adult patients with COVID-19 in Barcelona, Spain

Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis

Diagnostic performance and feasibility of two new treatment decision algorithms for pulmonary tuberculosis in children: A diagnostic and mixed-methods multi-country study

Impact on paediatric tuberculosis diagnosis of implementing the new treatment decision algorithms in an MSF nutritional centre, Maiduguri, Nigeria

Estimating post-treatment recurrence after multidrug-resistant tuberculosis treatment among patients with and without HIV: the impact of assumptions about death and missing follow-up

Pregnancy and birth outcomes in patients with multidrug-resistant tuberculosis treated with regimens that include new and repurposed drugs

Effectiveness of a bedaquiline, linezolid, clofazimine “core” for multidrug-resistant tuberculosis

Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa: Pooled analyses from five population-based surveys

Experiences and perceptions of urine sampling for tuberculosis testing among HIV patients: a multisite qualitative descriptive study

Evidence of HIV incidence reduction in young women, but not in adolescent girls, in KwaZulu-Natal, South Africa

Effectiveness of bedaquiline use beyond six months in patients with multidrug-resistant tuberculosis

Outcomes of WHO-conforming, longer, all-oral multidrug-resistant TB regimens and analysis implications

Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data