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Showing 1 - 20 of 95 Items
Showing 1 - 20 of 95 Items
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Research

Diagnostic accuracy of lung ultrasound for pulmonary tuberculosis in out-patients from Papua New Guinea, a resource-limited setting

Lightowler M, Min J, Nape A, Galowa T, Hemo C,  et al.
2025-11-01 • International Journal of Infectious Diseases
2025-11-01 • International Journal of Infectious Diseases

OBJECTIVE

To evaluate the diagnostic accuracy of lung ultrasound (LUS) for pulmonary tuberculosis (PTB) in Papua New Guinea.

METHODS

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Pre-Print
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Abstract

Implementation of treatment-decision algorithms for children with pulmonary tuberculosis: cross-cutting lessons for operational scale-up

Conference Material
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Slide Presentation

Implementation of treatment-decision algorithms for children with pulmonary tuberculosis: cross-cutting lessons for operational scale-up

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Commentary
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Short Report

Behavioral HIV-serosurvey reveals clustering of risk factors likely plays a key role in sustaining HIV epidemic in rural KwaZulu-Natal, South Africa

Conan N, Ben-Farhat J, Ohler L, Kenyon C, Van Cutsem G,  et al.
2025-10-10 • BMC Public Health
2025-10-10 • BMC Public Health

New Human immunodeficiency virus (HIV) infections among adults have decreased in the last ten years in high HIV prevalent countries. However, unsuppressed individuals with high-risk s...

Effect of smoking on drug-resistant tuberculosis treatment outcomes and exploring potential pathways: A multicountry cohort study

Romo ML, LaHood A, Stagg HR, Mitnick CD, Trevisi L,  et al.
2025-08-24 • medRxiv
2025-08-24 • medRxiv

People who smoke are at increased risk of unfavorable tuberculosis (TB) treatment outcomes compared with tho...

Characterizing treatment adherence trajectories in the endTB multisite cohort of drug-resistant tuberculosis patients: an application of group-based trajectory modelling

Law S, Fulcher I, Ashraf S, Bastard M, Docteur W,  et al.
2025-08-22 • Clinical Infectious Diseases
2025-08-22 • Clinical Infectious Diseases

BACKGROUND

In tuberculosis (TB) care, adherence is often assessed using a simple 80% threshold, ...

The frequency and incidence of QT prolongation with extended use of bedaquiline or delamanid in a large, multi-country multidrug-resistant/rifampicin-resistant tuberculosis cohort

Khan U, Rich M, Franke MF, Lachenal N, Ahmed S,  et al.
2025-08-01 • Clinical Infectious Diseases
2025-08-01 • Clinical Infectious Diseases

BACKGROUND

The 2022 World Health Organization (WHO) guidelines on multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) recommend 6 months of bedaqu...

Armour-Marshall J, Scarpa G, Abdullahi MB, Farouk Moussa Mamane O, Fidelle Nyikayo L,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
Armour-Marshall J, Scarpa G, Abdullahi MB, Farouk Moussa Mamane O, Fidelle Nyikayo L,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

Leveraging nutritional rehabilitation and tuberculosis programmes to tackle tuberculosis and severe acute malnutrition in children

Vonasek BJ, Marcy O, Armour J, Casenghi M, Cazes C,  et al.
2025-03-23 • Lancet Child and Adolescent Health
2025-03-23 • Lancet Child and Adolescent Health

Each day more than 500 children younger than 15 years die from tuberculosis. Considerable progress has been...

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R,  et al.
2025-02-01 • Lancet Child and Adolescent Health
2025-02-01 • Lancet Child and Adolescent Health

BACKGROUND

There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially ...

Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data

Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C,  et al.
2024-12-19 • Lancet Microbe
2024-12-19 • Lancet Microbe

BACKGROUND

Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the p...

The frequency and incidence of QT prolongation with extended use of bedaquiline or delamanid in a large, multi-country MDR/RR-TB cohort

Khan U, Rich M, Franke M, Lachenal N, Ahmed S,  et al.
2024-12-10 • Clinical Infectious Diseases
2024-12-10 • Clinical Infectious Diseases

BACKGROUND

The 2022 WHO guidelines on multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) recommend six months of bedaquiline (Bdq) in the all-oral 9-month shorter regimen ...

Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests: rationale and guidance for future research

Broger T, Marx FM, Theron G, Marais BJ, Nicol MP,  et al.
2024-07-01 • Lancet Global Health
2024-07-01 • Lancet Global Health

Changes over time in the proportion of advanced HIV disease in two high HIV prevalence settings in Ndhiwa (Kenya) and Eshowe (South Africa)

Chihana M, Conan N, Ohler L, Huerga H, Wanjala S,  et al.
2024-06-17 • Journal of the International Association of Providers of AIDS Care
2024-06-17 • Journal of the International Association of Providers of AIDS Care
BACKGROUND
The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...

Evaluation of a lung ultrasound score in hospitalized adult patients with COVID-19 in Barcelona, Spain

Lightowler MS, Sander JV, García de Casasola Sánchez G, Mateos González M, Güerri-Fernández R,  et al.
2024-06-02 • Journal of Clinical Medicine
2024-06-02 • Journal of Clinical Medicine
BACKGROUND
During the COVID-19 pandemic and the burden on hospital resources, the rapid categorization of high-risk COVID-19 patients became essential, and lung ultrasound (LUS) emer...

Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis

Kho S, Seung KJ, Huerga H, Bastard M, Khan PY,  et al.
2024-05-09 • Nature Communications
2024-05-09 • Nature Communications
Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT032592...

Diagnostic performance and feasibility of two new treatment decision algorithms for pulmonary tuberculosis in children: A diagnostic and mixed-methods multi-country study

Abdullahi MB, Issa-Soumana A-M, Namulwana ML, Barry I, Fidelle Nyikayo L,  et al.
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024

Impact on paediatric tuberculosis diagnosis of implementing the new treatment decision algorithms in an MSF nutritional centre, Maiduguri, Nigeria

Chara A, Abdullahi M, Ogundipe K, Briskin E, Phelan S,  et al.
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024

Estimating post-treatment recurrence after multidrug-resistant tuberculosis treatment among patients with and without HIV: the impact of assumptions about death and missing follow-up

Sauer SM, Mitnick CD, Khan UT, Hewison CCH, Bastard M,  et al.
2024-01-25 • Clinical Infectious Diseases
2024-01-25 • Clinical Infectious Diseases
BACKGROUND
Quantification of recurrence risk following successful treatment is crucial to evaluating regimens for multidrug- or rifampicin-resistant (MDR/RR) tuberculosis (TB). Howev...

Pregnancy and birth outcomes in patients with multidrug-resistant tuberculosis treated with regimens that include new and repurposed drugs

Lotia Farrukh I, Lachenal N, Adenov MM, Ahmed SM, Algozhin Y,  et al.
2024-01-25 • Clinical Infectious Diseases
2024-01-25 • Clinical Infectious Diseases
Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of ...