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Showing 1 - 20 of 21 Items
Showing 1 - 20 of 21 Items
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rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l’essai proches)

Watson CH, Gsell PS, Hall Y, Camacho A, Riveros X,  et al.
2024-11-07 • BMC Medicine
2024-11-07 • BMC Medicine

BACKGROUND

Zaire Ebolavirus disease (EVD) outbreaks can be controlled using rVSV-ZEBOV vaccination and other public health measures. People in high-risk areas m...

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Spatiotemporal modeling of cholera, Uvira, Democratic Republic of the Congo, 2016−2020

Ratnayake R, Knee J, Cumming O, Saidi JM, Rumedeka BB,  et al.
2024-08-01 • Emerging Infectious Diseases
2024-08-01 • Emerging Infectious Diseases

We evaluated the spatiotemporal clustering of rapid diagnostic test−positive cholera cases in Uvira, eastern Democratic Republic of the Congo. We detected spatiotemporal clusters that...

Assessing the performance of real-time epidemic forecasts: A case study of Ebola in the Western Area Region of Sierra Leone, 2014-15

Funk S, Camacho A, Kucharski AJ, Lowe R, Eggo RM,  et al.
2017-08-18 • bioRxiv
2017-08-18 • bioRxiv
Real-time forecasts based on mathematical models can inform critical decision-making during infectious disease outbreaks. Yet, epidemic forecasts are rarely evaluated during or after the...

Identifying human encounters that shape transmission of Streptococcus pneumoniae and other acute respiratory infections

le Polain de Waroux O, Flasche S, Kucharski AJ, Langendorf C, Ndazima D,  et al.
2018-12-01 • Epidemics
2018-12-01 • Epidemics
Although patterns of social contacts are believed to be an important determinant of infectious disease transmission, it remains unclear how the frequency and nature of human interactions...

Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: a survey in Southwest Uganda

le Polain de Waroux O, Cohuet S, Ndazima D, Kucharski AJ, Juan-Giner A,  et al.
2018-04-11 • BMC Infectious Diseases
2018-04-11 • BMC Infectious Diseases
BACKGROUND
Quantification of human interactions relevant to infectious disease transmission through social contact is central to predict disease dynamics, yet data from low-resource ...

Control of Ebola virus disease outbreaks: Comparison of health care worker-targeted and community vaccination strategies

Robert A, Camacho A, Edmunds WJ, Baguelin M, Muyembe JJT,  et al.
2019-03-02 • Epidemics
2019-03-02 • Epidemics
Health care workers (HCW) are at risk of infection during Ebola virus disease outbreaks and therefore may be targeted for vaccination before or during outbreaks. The effect of these stra...

The impact of reactive mass vaccination campaigns on measles outbreaks in the Katanga region, Democratic Republic of Congo

Funk S, Takahashi S, Hellewell J, Gadroen K, Carrion Martin AI,  et al.
2019-08-17 • medRxiv
2019-08-17 • medRxiv
The Katanga region in the Democratic Republic of Congo (DRC) has been struck by repeated epidemics of measles, with large outbreaks occurring in 2010–13 and 2015. In many of the affected...

Highly targeted spatiotemporal interventions against cholera epidemics, 2000–19: a scoping review

Ratnayake R, Finger F, Azman AS, Lantagne D, Funk S,  et al.
2021-03-01 • Lancet Infectious Diseases
2021-03-01 • Lancet Infectious Diseases
Globally, cholera epidemics continue to challenge disease control. Although mass campaigns covering large populations are commonly used to control cholera, spatial targeting of case hous...

Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach

Métras R, Fournié G, Dommerques L, Camacho A, Cavalerie L,  et al.
2017-07-21 • PLOS Neglected Tropical Diseases
2017-07-21 • PLOS Neglected Tropical Diseases
Rift Valley fever (RVF) is a major zoonotic and arboviral hemorrhagic fever. The conditions leading to RVF epidemics are still unclear, and the relative role of climatic and anthropogeni...

Measuring the unknown: an estimator and simulation study for assessing case reporting during epidemics

Jarvis CI, Gimma A, Finger F, Morris TP, Thompson JA,  et al.
2022-05-23 • PLoS Computational Biology
2022-05-23 • PLoS Computational Biology
The fraction of cases reported, known as 'reporting', is a key performance indicator in an outbreak response, and an essential factor to consider when modelling epidemics and assessing t...

Evaluation of the benefits and risks of introducing Ebola community care centers, Sierra Leone

Kucharski AJ, Camacho A, Checchi F, Waldman RJ, Grais RF,  et al.
2015-03-01 • Emerging Infectious Diseases
2015-03-01 • Emerging Infectious Diseases
In some parts of western Africa, Ebola treatment centers (ETCs) have reached capacity. Unless capacity is rapidly scaled up, the chance to avoid a generalized Ebola epidemic will soon di...

Assessing the performance of real-time epidemic forecasts: a case study of the 2013–16 Ebola epidemic

Funk S, Camacho A, Kucharski AJ, Lowe R, Eggo RM,  et al.
2019-02-11 • PLoS Computational Biology
2019-02-11 • PLoS Computational Biology
Real-time forecasts based on mathematical models can inform critical decision-making during infectious disease outbreaks. Yet, epidemic forecasts are rarely evaluated during or after the...

Efficacy and Effectiveness of an rVSV-Vectored Vaccine in Preventing Ebola Virus Disease: Final Results from the Guinea Ring Vaccination, Open-Label, Cluster-Randomised Trial (Ebola Ça Suffit!)

Henao-Restrepo AM, Camacho A, Longini I, Watson CH, Edmunds WJ,  et al.
2017-02-01 • Lancet
2017-02-01 • Lancet
BACKGROUND
rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the ...

Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study

Ratnayake R, Peyraud N, Ciglenecki I, Gignoux EM, Lightowler M,  et al.
2022-07-06 • BMJ Open
2022-07-06 • BMJ Open
INTRODUCTION
Cholera outbreaks in fragile settings are prone to rapid expansion. Case-area targeted interventions (CATIs) have been proposed as a rapid and efficient response strateg...

Temporal Changes in Ebola Transmission in Sierra Leone and Implications for Control Requirements: a Real-time Modelling Study

Camacho A, Kucharski AJ, Aki-Sawyerr Y, White M, Flasche S,  et al.
2015-02-10 • PLoS Currents
2015-02-10 • PLoS Currents
Between August and November 2014, the incidence of Ebola virus disease (EVD) rose dramatically in several districts of Sierra Leone. As a result, the number of cases exceeded the capacit...

Estimation of Rift Valley fever virus spillover to humans during the Mayotte 2018–2019 epidemic

Metras R, Edmunds WJ, Youssouffi C, Dommergues L, Fournié G,  et al.
2020-09-29 • Proceedings of the National Academy of Sciences
2020-09-29 • Proceedings of the National Academy of Sciences
Rift Valley fever (RVF) is an emerging, zoonotic, arboviral hemorrhagic fever threatening livestock and humans mainly in Africa. RVF is of global concern, having expanded its geographica...

The impact of control strategies and behavioural changes on the elimination of ebola from Lofa County, Liberia

Funk S, Ciglenecki I, Tiffany A, Gignoux EM, Camacho A,  et al.
2017-04-10 • Philosophical Transactions of the Royal Society B: Biological Sciences
2017-04-10 • Philosophical Transactions of the Royal Society B: Biological Sciences
The Ebola epidemic in West Africa was stopped by an enormous concerted effort of local communities and national and international organizations. It is not clear, however, how much the pu...

Measuring the unknown: an estimator and simulation study for assessing case reporting during epidemics

Jarvis CI, Gimma A, Finger F, Morris TP, Thompson JA,  et al.
2021-02-17 • bioRxiv
2021-02-17 • bioRxiv
The fraction of cases reported, known as ‘reporting’, is a key performance indicator in an outbreak response, and an essential factor to consider when modelling epidemics and assessing t...

Protocol for a phase 3 trial to evaluate the effectiveness and safety of a heterologous, two-dose vaccine for Ebola virus disease in the Democratic Republic of the Congo

Watson-Jones D, Kavunga-Membo H, Grais RF, Ahuka S, Roberts N,  et al.
2022-03-08 • BMJ Open
2022-03-08 • BMJ Open
INTRODUCTION
Ebola virus disease (EVD) continues to be a significant public health problem in sub-Saharan Africa, especially in the Democratic Republic of the Congo (DRC). Large-scal...

Inference is bliss: simulation for power estimation for an observational study of a cholera outbreak intervention

Ratnayake R, Checchi F, Jarvis CI, Edmunds WJ, Finger F
2022-02-16 • PLOS Neglected Tropical Diseases
2022-02-16 • PLOS Neglected Tropical Diseases
BACKGROUND
The evaluation of ring vaccination and other outbreak-containment interventions during severe and rapidly-evolving epidemics presents a challenge for the choice of a feasi...