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Showing 1 - 16 of 16 Items
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Research

Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children

Delmas V, Vasiliu A, Tchakounté Youngui B, Ssekyanzi B, Kuate Kuate A,  et al.
2025-06-27 • International Journal of Tuberculosis and Lung Disease
2025-06-27 • International Journal of Tuberculosis and Lung Disease

BACKGROUND

The ‘CaP-TB’ project enhanced paediatric TB care through decentralized services, including screening, specimen collection, chest X-rays and implement...

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COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

Leveraging nutritional rehabilitation and tuberculosis programmes to tackle tuberculosis and severe acute malnutrition in children

Vonasek BJ, Marcy O, Armour J, Casenghi M, Cazes C,  et al.
2025-03-23 • Lancet Child and Adolescent Health
2025-03-23 • Lancet Child and Adolescent Health

Each day more than 500 children younger than 15 years die from tuberculosis. Considerable progress has been...

Integration of HIV testing in a community intervention for tuberculosis screening among household contacts of patients with tuberculosis in Cameroon and Uganda

Youngui BT, Atwine D, Otai D, Vasiliu A, Ssekyanzi B,  et al.
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2024-04-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
INTRODUCTION
People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore cri...

Effectiveness of a community-based approach for the investigation and management of children with household tuberculosis contact in Cameroon and Uganda: a cluster-randomised trial

Bonnet MMB, Vasiliu A, Tchounga BK, Cuer B, Fielding K,  et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing chi...

Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial

Mafirakureva N, Tchounga BK, Mukherjee S, Youngui BT, Ssekyanzi B,  et al.
2023-10-30 • Lancet Global Health
2023-10-30 • Lancet Global Health
BACKGROUND
WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children. The CONTACT trial found in...

Reversing the neglect of children and adolescents affected by tuberculosis

Deborggraeve S, Casenghi M, Hewison CCH, Ditekemena J, Ditiu L,  et al.
2023-09-11 • Lancet Child and Adolescent Health
2023-09-11 • Lancet Child and Adolescent Health

Lots of considerations when evaluating the FujiLAM assay – Author's reply

Huerga H, Gupta-Wright A, Muyindike WR, Hewison CCH, Casenghi M,  et al.
2023-04-01 • Lancet Global Health
2023-04-01 • Lancet Global Health

Implementing the Xpert MTB/RIF diagnostic test for tuberculosis and rifampicin resistance: outcomes and lessons learned in 18 countries

Ardizzoni E, Fajardo E, Saranchuk P, Casenghi M, Page AL,  et al.
2015-12-15 • PLOS One
2015-12-15 • PLOS One
BACKGROUND
The Xpert® MTB/RIF (Xpert) is an automated molecular test for simultaneous detection of tuberculosis (TB) and rifampicin resistance, recommended by the World Health Organi...

New diagnostics for tuberculosis: fulfilling patient needs first

Lemaire J-F, Casenghi M
2010-01-01 • Journal of the International AIDS Society
2010-01-01 • Journal of the International AIDS Society
BACKGROUND

An effective tuberculosis (TB) control programme requires early diagnosis and immediate initiation of treatment. Any delays in diagnosing TB not only impair a patient...

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities

McNerney R, Maeurer M, Abubakar I, Marais BJ, McHugh TD,  et al.
2012-04-10 • Journal of Infectious Diseases
2012-04-10 • Journal of Infectious Diseases
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to...

New approaches to filling the gap in tuberculosis drug discovery

Casenghi M, Cole ST, Nathan CF
2007-11-06 • PLOS Medicine
2007-11-06 • PLOS Medicine

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study

Huerga H, Bastard M, Lubega AV, Akinyi M, Antabak NT,  et al.
2023-01-01 • Lancet Global Health
2023-01-01 • Lancet Global Health
BACKGROUND
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnost...

Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel

Graham SM, Ahmed T, Amanullah F, Browning R, Cardenas V,  et al.
2012-05-15 • Journal of Infectious Diseases
2012-05-15 • Journal of Infectious Diseases
There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tubercul...

Defining the Needs for Next Generation Assays for Tuberculosis

Denkinger CM, Kik S, Cirillo DM, Casenghi M, Shinnick T,  et al.
2015-04-01 • Journal of Infectious Diseases
2015-04-01 • Journal of Infectious Diseases
To accelerate the fight against tuberculosis, major diagnostic challenges need to be addressed urgently. Post-2015 targets are unlikely to be met without the use of novel diagnostics tha...

Feasibility of a randomized clinical trial evaluating a community intervention for household tuberculosis child contact management in Cameroon and Uganda

Vasiliu A, Tiendrebeogo G, Mbunka Awolu M, Akatukwasa C, Youngui Tchakounte B,  et al.
2022-02-11 • Pilot and Feasibility Studies
2022-02-11 • Pilot and Feasibility Studies
BACKGROUND
One of the main barriers of the management of household tuberculosis child contacts is the necessity for parents to bring healthy children to the facility. We assessed the...