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Copyright © Médecins Sans Frontières
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Showing 1 - 20 of 50 Items
Showing 1 - 20 of 50 Items
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Journal Article
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Research

Mycoplasma genitalium infection in Eswatini amid syndromic case management: Prevalence, coinfections, diagnostic challenges and treatment gaps

Kerschberger B, Lekelem S, Daka M, Ntshalintshali N, Mabhena E,  et al.
2025-04-17 • BMC Infectious Diseases
2025-04-17 • BMC Infectious Diseases

BACKGROUND

The global epidemic of Mycoplasma genitalium (MG) is marked by its widespread prevalence, varied resistance patterns, and significant impact on sexua...

Journal Article
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Research

An automated literature review tool (LiteRev) for streamlining and accelerating research using natural language processing and machine learning: Descriptive performance evaluation study

Orel EB, Ciglenecki I, Thiabaud A, Temerev A, Calmy A,  et al.
2023-09-15 • ACG Case Reports Journal
2023-09-15 • ACG Case Reports Journal
BACKGROUND
Literature reviews (LRs) identify, evaluate, and synthesize relevant papers to a particular research question to advance understanding and support decision-making. However...
Conference Material
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Abstract

High burden of sexually transmitted infections and poor diagnostic performance of syndromic approaches within a decentralised HIV care setting in Eswatini

Kerschberger B, Ntshalintshali N, Mafomisa M, Mabhena E, Daka M,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
INTRODUCTION
Sexually transmitted infections (STI’s) are a public health threat. Syndromic approaches based on clinical symptoms have been suggested as having poor diagnostic perform...
Journal Article
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Commentary

Generating evidence to improve the response to neglected diseases: how operational research in a Médecins Sans Frontières Buruli ulcer treatment programme informed international management guidance

O'Brien DP, Ford NP, Vitoria M, Asiedu K, Calmy A,  et al.
2015-11-12 • PLOS Neglected Tropical Diseases
2015-11-12 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

Bonnet MMB, Bhatt NB, Baudin E, Silva C, Michon C,  et al.
2013-04-01 • Lancet Infectious Diseases
2013-04-01 • Lancet Infectious Diseases
BACKGROUND
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antitube...
Journal Article
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Research

Highly active antiretroviral therapy in resource-poor settings: the experience of Médecins Sans Frontières

Tassie JM, Szumilin E, Calmy A, Goemaere E
2003-09-05 • AIDS
2003-09-05 • AIDS
We describe the short-term results of highly active antiretroviral therapy (HAART) in seven projects in low and middle income countries. A total of 743 adults were included, and clinical...
Journal Article
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Review

Female Genital Schistosomiasis and HIV: Research urgently needed to improve understanding of the health impacts of this important co-infection

O'Brien DP, Ford NP, Djirmay AG, Calmy A, Victoria M,  et al.
2019-01-25 • Journal of Acquired Immune Deficiency Syndromes (1999)
2019-01-25 • Journal of Acquired Immune Deficiency Syndromes (1999)
Evidence suggests that there are important interactions between HIV and Female Genital Schistosomiasis (FGS) that may have significant effects on individual and population health. Howeve...
Journal Article
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Research

Causes of hospital admission among people living with HIV worldwide: a systematic review and meta-analysis

Ford NP, Shubber Z, Meintjes GA, Grinsztejn B, Eholie SP,  et al.
2015-08-11 • Lancet HIV
2015-08-11 • Lancet HIV
Journal Article
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Research

Treatment failure and mortality factors in patients receiving second-line HIV therapy in resource-limited countries

Pujades-Rodríguez M, Balkan S, Arnould L, Brinkhof MW, Calmy A
2010-07-21 • Journal of the American Medical Association (JAMA)
2010-07-21 • Journal of the American Medical Association (JAMA)
CONTEXT
Long-term antiretroviral therapy (ART) use in resource-limited countries leads to increasing numbers of patients with HIV taking second-line therapy. Limited access to furthe...
Journal Article
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Commentary

When to start antiretroviral therapy in resource-limited settings: a human rights analysis

Ford NP, Calmy A, Hurst S
2010-03-31 • BMC International Health and Human Rights
2010-03-31 • BMC International Health and Human Rights
ABSTRACT: BACKGROUND: Recent evidence from developed and developing countries shows clear clinical and public health benefit to starting antiretroviral therapy (ART) earlier. While discu...
Journal Article
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Research

Highly active antiretroviral therapy in resource-poor settings: the experience of Medecins Sans Frontieres

Tassie JM, Szumilin E, Calmy A, Goemaere E
2003-09-01 • AIDS
2003-09-01 • AIDS
We describe the short-term results of highly active antiretroviral therapy (HAART) in seven projects in low and middle income countries. A total of 743 adults were included, and clinical...
Journal Article
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Research

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring

Keiser O, Tweya H, Boulle AM, Braitstein P, Schechter M,  et al.
2009-09-10 • AIDS
2009-09-10 • AIDS
BACKGROUND
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring ...
Journal Article
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Research

Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome

Bonnet MMB, Baudin E, Jani IV, Nunes E, Verhoustraeten F,  et al.
2013-12-18 • PLOS One
2013-12-18 • PLOS One
OBJECTIVES AND DESIGN
We used data from a randomized trial of HIV-tuberculosis co-infected patients in Mozambique to determine the incidence and predictors of paradoxical tuberculosi...
Journal Article
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Pre-Print

Early assessment of antiretroviral efficacy is critical to prevent the emergence of resistance mutations in HIV-tuberculosis coinfected patients: a substudy of the CARINEMO-ANRS12146 trial

Baudin E, Bhatt NB, Rouzioux C, Serafini M, Molfino L,  et al.
2019-02-08 • F1000Research
2019-02-08 • F1000Research
BACKGROUND
In the CARINEMO ANRS 12146 clinical trial, HIV-tuberculosis co-infected patients in Mozambique were randomized to nevirapine (NVP) or to efavirenz (EFV)-based antiretrovir...
Journal Article
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Review

Review of the safety, efficacy, and pharmacokinetics of elvitegravir with an emphasis on resource-limited settings

Ford NP, Lee JS, Andrieux-Meyer I, Calmy A
2012-01-11 • HIV/AIDS - Research and Palliative Care
2012-01-11 • HIV/AIDS - Research and Palliative Care
Integrase inhibitors represent an important new class of antiretroviral drugs. Elvitegravir, the second available integrase inhibitor to be submitted for regulatory approval appears to b...
Journal Article
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Commentary

The future role of CD4 cell count for monitoring antiretroviral therapy

Ford NP, Meintjes GA, Pozniak A, Bygrave H, Hill AM,  et al.
2014-11-19 • Lancet Infectious Diseases
2014-11-19 • Lancet Infectious Diseases
For more than two decades, CD4 cell count measurements have been central to understanding HIV disease progression, making important clinical decisions, and monitoring the response to ant...
Journal Article
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Commentary

HIV and Ebola virus: two jumped species but not two of a kind

Calmy A, Goemaere E, van Cutsem G
2015-08-24 • AIDS
2015-08-24 • AIDS
Journal Article
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Research

Impact of Human Immunodeficiency Virus on the Severity of Buruli Ulcer Disease: Results of a Retrospective Study in Cameroon

Christinet V, Rossel L, Serafini M, Delhumeau C, Odermatt P,  et al.
2014-04-26 • Open Forum Infectious Diseases
2014-04-26 • Open Forum Infectious Diseases
Abstract
Background.  Buruli ulcer is the third most common mycobacterial disease after tuberculosis and leprosy and is particularly f...
Journal Article
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Commentary

Preferred antiretroviral drugs for the next decade of scale up

Andrieux-Meyer I, Calmy A, Cahn P, Clayden P, Raguin G,  et al.
2012-09-18 • Journal of the International AIDS Society
2012-09-18 • Journal of the International AIDS Society
Global commitments aim to provide antiretroviral therapy (ART) to 15 million people living with HIV by 2015, and recent studies have demonstrated the potential for widespread ART to prev...
Conference Material
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Abstract

Diagnostic performance of lateral flow point-of-care HIV-Combo testing for detection of acute HIV infection in Eswatini

Kerschberger B, Ntshalintshali N, Maphalala G, Aung A, Mamba C,  et al.
2021-05-19 • MSF Scientific Days International 2021: Research
2021-05-19 • MSF Scientific Days International 2021: Research
INTRODUCTION
Acute HIV infection (AHI) is rarely diagnosed in resource-limited settings. Barriers to diagnosis include the high costs of viral load (VL)-based diagnostic testing algo...