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Snakebite envenoming: a neglected health crisis | Collections | MSF Science Portal
Snakebite envenoming: a neglected health crisis

Snakebite envenoming: a neglected health crisis

Every year 2 million or more people fall victim to snakebite envenoming, mostly in poor, rural communities of Africa, Asia and Latin America. Between 83,000—138,000 of them die, while hundreds of thousands more suffer debilitating long-term complications or disabilities.


Although some antivenom medicines are highly effective when used promptly and appropriately, many snakebite victims get no treatment at all. Those who do may receive antivenoms which don’t work against the type of snake that bit them, or were not rigorously tested for safety and effectiveness.


To mark World Snakebite Awareness Day on September 19th, the Collection linked below brings together recent MSF work on this highly neglected disease. Several articles and conference presentations help fill evidence gaps on the burden of disease and its impacts or on treatment outcomes with specific antivenoms. Others examine how to tackle the formidable challenges of availability and affordability, the absence of regulatory oversight for making, testing and registering antivenoms, and the anemic R&D pipeline for new products—all of which impede access for patients to safe, effective treatment tailored to local snake species.

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MSF Paediatric Days 2024 abstracts

MSF Paediatric Days 2024 abstracts
On 3-4 May in Nairobi, Kenya, MSF gathered staff from our projects with experts from academia, clinical practice and the non-governmental sector to consider key issues in humanitarian paediatrics. These included: Vaccination and vaccine-preventable diseases: Amid post-Covid-19 global setbacks in child vaccination coverage, sessions spotlighted recent increases in vaccine-preventable disease outbreaks, potential new vaccination strategies and emergency responses, and MSF’s role in vaccine advocacy and catch-up campaigns. Nutrition: Talks covered the nexus of nutrition with other key conference topics, the latest malnutrition guidance and tools, and MSF’s priorities in nutritional care. Paediatric HIV: With half of all HIV-positive children globally not receiving antiretroviral therapy, presenters reviewed the latest paediatric testing/treatment recommendations and discussed barriers and potential solutions to implementation, nutritional challenges in children with HIV, and systems strengthening for preventing and monitoring paediatric HIV. Click below to read the abstracts. And stay tuned for more conference content, coming soon.
Medical and humanitarian harms of restrictive European migration policies

Medical and humanitarian harms of restrictive European migrat...
Mini-Lab—MSF's simplified bacteriology laboratory for low-resource settings

Mini-Lab—MSF's simplified bacteriology laboratory for low-res...
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Conflict, persecution, poverty, food insecurity and natural disasters—increasingly fueled by climate change—continue to drive migration globally. Yet many wealthy countries are doubling down on hostile policies to prevent people from seeking safety within their borders, thereby subjecting them to a wide range of harms. In a newly-published report MSF focuses on European Union and member state policies that intensify exposure to violence, exploitation, risk of drowning at sea, disease, and lack of access to basic health care and shelter, both within European Union borders and beyond. The Collection linked below presents this report alongside selected publications illustrating the broader context, based on quantitative studies and accounts from MSF patients and medical teams over nearly a decade of operational experience along the European migration route. From violent, squalid detention centers in Libya— where people intercepted by the EU-supported Libyan coast guard are forcibly returned —to perilous Mediterranean crossings in flimsy rubber boats and often abysmal reception centers and camps within the EU, it documents how these policies and practices further harm highly vulnerable people seeking safety and protection.
Resistance to antibiotics is a growing public health crisis, especially in countries with fragile health systems and in regions at war. One key limitation in most of these settings is a lack of clinical bacteriology laboratory capacity, which leaves medical providers without ways to accurately diagnose patient infections and to tailor antibiotic treatment accordingly. To help fill this critical gap, MSF and partners have developed the Mini-Lab—a small-scale, standalone lab that is easy to transport, set up and operate by staff after only a short training. Its six modules are stocked with everything needed to diagnose common bloodstream and urinary tract infections and to perform antibiotic sensitivity testing using methods adapted to extremely hot climates and remote settings. With Mini-Lab now being rolled out to selected MSF projects, here we highlight the background to its development and some of the research behind the bacteriological tests it incorporates.
Conference Material
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Poster

Characteristics of children affected by snake bite and snake envenomation in Abs Hospital, Yemen

de Bartolome Gisbert F, Awad Alhatec MH, Hajaji A, Hindi A, Salem S,  et al.
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024
Journal Article
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Research

Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon

Chippaux JP, Ntone R, Benhammou D, Madec Y, Noël G,  et al.
2023-11-08 • PLOS Neglected Tropical Diseases
2023-11-08 • PLOS Neglected Tropical Diseases
BACKGROUND
Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiven...
Journal Article
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Commentary

Availability, accessibility and use of antivenom for snakebite envenomation in Africa with proposed strategies to overcome the limitations

Dalhat MM, Potet J, Mohammed A, Chotun N, Tesfahunei HA,  et al.
2023-02-26 • Toxicon: X
2023-02-26 • Toxicon: X
Africa remains one of the regions with the highest incident and burden of snakebite. The goal of the World Health Organization to halve the global burden of snakebite by 2030 can only be...
Journal Article
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Research

A global core outcome measurement set for snakebite clinical trials

Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H,  et al.
2023-02-01 • Lancet Global Health
2023-02-01 • Lancet Global Health
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came togethe...
Journal Article
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Commentary

Snakebite envenoming at MSF: A decade of clinical challenges and antivenom access issues

Potet J, Singh SN, Ritmeijer KKD, Sisay K, Alcoba G,  et al.
2022-12-21 • Toxicon: X
2022-12-21 • Toxicon: X
The medical humanitarian organization Médecins Sans Frontières (MSF) provides medical care in more than 70 countries and admits more than 7000 cases of snakebite in its facilities each y...
Journal Article
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Commentary

Understanding and tackling snakebite envenoming with transdisciplinary research

Gutiérrez JM, Borri J, Giles-Vernick T, Duda R, Habib AG,  et al.
2022-11-17 • PLOS Neglected Tropical Diseases
2022-11-17 • PLOS Neglected Tropical Diseases
Journal Article
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Review

Snakebite envenoming in humanitarian crises and migration: A scoping review and the Médecins Sans Frontières experience

Alcoba G, Potet J, Vatrinet R, Singh SN, Nanclares C,  et al.
2022-03-01 • Toxicon: X
2022-03-01 • Toxicon: X
Snakebite envenoming is a public health concern in many countries affected by humanitarian crises. Its magnitude was recognized internationally but associations between snakebite peaks a...
Journal Article
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Research

Treatment outcomes among snakebite patients in north-west Ethiopia—a retrospective analysis

Steegemans IM, Sisay K, Nshimiyimana E, Gebrewold G, Piening T,  et al.
2022-02-09 • PLOS Neglected Tropical Diseases
2022-02-09 • PLOS Neglected Tropical Diseases
BACKGROUND
Millions of people are bitten by venomous snakes annually, causing high mortality and disability, but the true burden of this neglected health issue remains unknown. Since...
Journal Article
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Review

Access to antivenoms in the developing world: a multidisciplinary analysis

Potet J, Beran D, Ray N, Alcoba G, Habib AG,  et al.
2021-10-26 • Toxicon: X
2021-10-26 • Toxicon: X
Access to safe, effective, quality-assured antivenom products that are tailored to endemic venomous snake species is a crucial component of recent coordinated efforts to reduce the globa...
Journal Article
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Commentary

Snakebites and COVID-19: two crises, one research and development opportunity

Martins D, Ribeiro I, Potet J
2021-10-25 • BMJ Global Health
2021-10-25 • BMJ Global Health
SUMMARY POINTS

• Despite inherent differences, Snakebite Envenoming and COVID-19 have much in common in terms of research and development (R&D) challenges and opportunities.