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Snakebite envenoming: a neglected health crisis | Collections | MSF Science Portal

Every year 2 million or more people fall victim to snakebite envenoming, mostly in poor, rural communities of Africa, Asia and Latin America. Between 83,000—138,000 of them die, while hundreds of thousands more suffer debilitating long-term complications or disabilities.


Although some antivenom medicines are highly effective when used promptly and appropriately, many snakebite victims get no treatment at all. Those who do may receive antivenoms which don’t work against the type of snake that bit them, or were not rigorously tested for safety and effectiveness.


To mark World Snakebite Awareness Day on September 19th, the Collection linked below brings together recent MSF work on this highly neglected disease. Several articles and conference presentations help fill evidence gaps on the burden of disease and its impacts or on treatment outcomes with specific antivenoms. Others examine how to tackle the formidable challenges of availability and affordability, the absence of regulatory oversight for making, testing and registering antivenoms, and the anemic R&D pipeline for new products—all of which impede access for patients to safe, effective treatment tailored to local snake species.

Collection Content

Conference Material
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Poster

Characteristics of children affected by snake bite and snake envenomation in Abs Hospital, Yemen

de Bartolome Gisbert F, Awad Alhatec MH, Hajaji A, Hindi A, Salem S,  et al.
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024
Journal Article
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Research

Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon

Chippaux JP, Ntone R, Benhammou D, Madec Y, Noël G,  et al.
2023-11-08 • PLOS Neglected Tropical Diseases
2023-11-08 • PLOS Neglected Tropical Diseases
BACKGROUND
Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiven...
Journal Article
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Commentary

Availability, accessibility and use of antivenom for snakebite envenomation in Africa with proposed strategies to overcome the limitations

Dalhat MM, Potet J, Mohammed A, Chotun N, Tesfahunei HA,  et al.
2023-02-26 • Toxicon: X
2023-02-26 • Toxicon: X
Africa remains one of the regions with the highest incident and burden of snakebite. The goal of the World Health Organization to halve the global burden of snakebite by 2030 can only be...
Journal Article
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Research

A global core outcome measurement set for snakebite clinical trials

Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H,  et al.
2023-02-01 • Lancet Global Health
2023-02-01 • Lancet Global Health
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came togethe...
Journal Article
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Commentary

Snakebite envenoming at MSF: A decade of clinical challenges and antivenom access issues

Potet J, Singh SN, Ritmeijer KKD, Sisay K, Alcoba G,  et al.
2022-12-21 • Toxicon: X
2022-12-21 • Toxicon: X
The medical humanitarian organization Médecins Sans Frontières (MSF) provides medical care in more than 70 countries and admits more than 7000 cases of snakebite in its facilities each y...
Journal Article
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Commentary

Understanding and tackling snakebite envenoming with transdisciplinary research

Gutiérrez JM, Borri J, Giles-Vernick T, Duda R, Habib AG,  et al.
2022-11-17 • PLOS Neglected Tropical Diseases
2022-11-17 • PLOS Neglected Tropical Diseases
Journal Article
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Review

Snakebite envenoming in humanitarian crises and migration: A scoping review and the Médecins Sans Frontières experience

Alcoba G, Potet J, Vatrinet R, Singh SN, Nanclares C,  et al.
2022-03-01 • Toxicon: X
2022-03-01 • Toxicon: X
Snakebite envenoming is a public health concern in many countries affected by humanitarian crises. Its magnitude was recognized internationally but associations between snakebite peaks a...
Journal Article
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Research

Treatment outcomes among snakebite patients in north-west Ethiopia—a retrospective analysis

Steegemans IM, Sisay K, Nshimiyimana E, Gebrewold G, Piening T,  et al.
2022-02-09 • PLOS Neglected Tropical Diseases
2022-02-09 • PLOS Neglected Tropical Diseases
BACKGROUND
Millions of people are bitten by venomous snakes annually, causing high mortality and disability, but the true burden of this neglected health issue remains unknown. Since...
Journal Article
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Review

Access to antivenoms in the developing world: a multidisciplinary analysis

Potet J, Beran D, Ray N, Alcoba G, Habib AG,  et al.
2021-10-26 • Toxicon: X
2021-10-26 • Toxicon: X
Access to safe, effective, quality-assured antivenom products that are tailored to endemic venomous snake species is a crucial component of recent coordinated efforts to reduce the globa...
Journal Article
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Commentary

Snakebites and COVID-19: two crises, one research and development opportunity

Martins D, Ribeiro I, Potet J
2021-10-25 • BMJ Global Health
2021-10-25 • BMJ Global Health
SUMMARY POINTS

• Despite inherent differences, Snakebite Envenoming and COVID-19 have much in common in terms of research and development (R&D) challenges and opportunities.

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Adapting essential care programs to Covid-19 pandemic times
Adapting essential care programs to Covid-19 pandemic times
As the ongoing Covid-19 pandemic grips the world, one of its most devastating indirect effects is the disruption to medical services for preventing and treating other life-threatening diseases—especially in countries with already-fragile health systems. For MSF and other global health actors this means not only responding to Covid-19 directly but also assessing its impact on other essential care and then adapting programs so they can keep serving patients despite the enormous obstacles. In this Collection you will find a selection of published articles and conference content from this year’s MSF Scientific Days 2021 conference content, encompassing a range of approaches, settings and medical challenges—from malaria, TB and HIV/AIDS prevention and care to digital health promotion and sexual and reproductive health.
TB Union Conference 2022
TB Union Conference 2022
Innovation in preventing, diagnosing and treating drug-resistant tuberculosis (DR-TB) cannot come fast enough—especially given the ground lost due to the Covid-19 pandemic, and with only 1 in 3 people who have DR-TB now receiving care. The content collection linked below offers a snapshot of recent TB work by MSF and collaborators to help change this picture. The TB-PRACTECAL and endTB studies have delivered clear evidence for shorter, safer, more effective treatments against drug-resistant (DR)-TB. Faced with the many hurdles that lie ahead before these and other critical interventions can be widely accessible, other studies investigate patient/family-based models of care adapted to complex settings and neglected groups, including children. Last, several authors explore limited but potentially important options for expanding diagnosis and preventive treatment.
Covid-19 in humanitarian settings—modelling, measuring & applying lessons (MSF Scientific Days International 2022)
Covid-19 in humanitarian settings—modelling, measuring & appl...
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Snakebite envenoming: a neglected health crisis

Snakebite envenoming: a neglected health crisis