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Yellow fever | Collections | MSF Science Portal

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Combatting antibiotic resistance 2022
Combatting antibiotic resistance 2022
Resistance to antibiotics is a growing public health crisis, especially in countries with fragile health systems and in regions at war. The World Health Organization has estimated that antibiotic-resistant bacteria caused nearly 1.3 million deaths in 2019, a toll that will increase significantly in the coming years if effective action is not taken. To mark World Antimicrobial Awareness Week 2022 (18-24 November) we present a snapshot of MSF’s recent work on responding to this growing threat. Since many humanitarian settings lack laboratory capacity to diagnose these infections, MSF and partners have developed two new technologies with the potential to dramatically expand the availability of accurate diagnosis—allowing clinicians to then tailor antibiotic treatment accordingly. Other work from diverse contexts describes practices and challenges related to optimizing rational antibiotic use within health facilities and communities. Lastly, several studies characterize the patterns and prevalence of antibiotic resistance among MSF patients, from hospitalized neonates in Central African Republic to acute trauma patients in Haiti and Yemen.
Expanding access to lifesaving new TB tools
Expanding access to lifesaving new TB tools
Many settings with a high burden of drug-resistant tuberculosis (DR-TB) lack access to advanced diagnostics and to groundbreaking new treatments. The Collection linked below spotlights work by MSF and collaborators to analyze barriers, identify gaps, and accelerate the roll-out of these tools to people whose lives hang in the balance. Several reports examine price, regulatory, and patent obstacles that persist despite considerable public investment into developing many of these tools. Other authors examine critical remaining weaknesses in care pathways—especially in screening and diagnosis, and particularly in children. Several studies describe new strategies that could be part of the solution, from a pilot program in Tajikisttan that trains family caregivers to treat children with DR-TB at home, to a person-centered care model adapted to a conflict zone in Afghanistan. Lastly, initial findings demonstrate that pregnant women—another vulnerable population—can be effectively treated for DR- and multidrug-resistant TB, improving maternal outcomes without harming neonates.
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Advancing Research to Improve NTD Treatments in Children by S...

Dr. Saschveen Singh is a tropical infectious disease advisor for MSF. Read more of MSF's recent work on neglected tropical diseases in pediatric populations, and of Dr. Singh's work at MSF.

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Journal Article
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Commentary

Yellow fever resurgence: An avoidable crisis?

Lindsey NP, Horton J, Barrett ADT, Demanou M, Monath TP,  et al.
2022-11-02 • NPJ Vaccines
2022-11-02 • NPJ Vaccines
Journal Article
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Research

Missed opportunities for vaccination (MOV) in children up to 5 years old in 19 Médecins Sans Frontières-supported health facilities: a cross-sectional survey in six low-resource countries

Borras-Bermejo B, Panunzi I, Bachy C, Gil-Cuesta J
2022-07-26 • BMJ Open
2022-07-26 • BMJ Open
OBJECTIVE
To describe missed opportunities for vaccination (MOV) among children visiting Médecins Sans Frontières (MSF)-supported facilities, their related factors, and to identify r...
Conference Material
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Video

Immunogenicity of fractional dose yellow fever vaccine in children and HIV+ adults

Namulwana ML
2022-06-21 • Epicentre Scientific Day Paris 2022
2022-06-21 • Epicentre Scientific Day Paris 2022
Journal Article
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Research

Metagenomic sequencing characterizes a wide diversity of viruses in field mosquito samples in Nigeria

Oguzie JU, Nwangwu UC, Oluniyi PE, Olumade TJ, George UE,  et al.
2022-05-10 • Scientific Reports
2022-05-10 • Scientific Reports
Mosquito vectors are a tremendous public health threat. One in six diseases worldwide is vector-borne transmitted mainly by mosquitoes. In the last couple of years, there have been activ...
Journal Article
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Pre-Print

The burden of vaccine hesitancy for routine immunization in Yaounde-Cameroon: restrictive sampling technique

Yakum MN, Funwie AD, Ajong AB, Tsafack M, Ebaze LE,  et al.
2022-02-21 • medRxiv
2022-02-21 • medRxiv
Immunization is the most cost-effective health intervention in the world yet, vaccination uptake is still low with less than 50% of children aged 12-23 months fully vaccinated Cameroon. ...
Conference Material
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Video

Fractional dosing of vaccines: when less could mean more

Juan A
2021-06-10 • Epicentre Scientific Day Paris 2021
2021-06-10 • Epicentre Scientific Day Paris 2021
Journal Article
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Research

Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial

Juan-Giner A, Kimathi D, Grantz KH, Hamaluba M, Kazooba P,  et al.
2021-01-09 • Lancet
2021-01-09 • Lancet
BACKGROUND
Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. Fractional dosing has shown efficacy, but evidence is limited to the 17...
Journal Article
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Research

Vaccination coverage survey versus administrative data in the assessment of mass yellow fever immunization in internally displaced persons—Liberia, 2004

Huhn GD, Brown J, Perea W, Berthe A, Otero H,  et al.
2006-02-06 • Vaccine
2006-02-06 • Vaccine
Yellow fever (YF) is a mosquito-borne vaccine-preventable disease with high mortality. In West Africa, low population immunity increases the risk of epidemic transmission. A cluster surv...
Journal Article
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Letter

Shortage of vaccines during a yellow fever outbreak in Guinea

Nathan N, Barry M, Van Herp M, Zeller H
2001-12-01 • Lancet
2001-12-01 • Lancet
A yellow fever epidemic erupted in Guinea in September, 2000. From Sept 4, 2000, to Jan 7, 2001, 688 instances of the disease and 225 deaths were reported. The diagnosis was laboratory c...
Yellow fever

Yellow fever