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TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs | Journal Article / Research | MSF Science Portal
Journal Article
|Research

TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs

Kosack CS, Page AL, Van Hulsteijn LT, Lentjes EG
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Abstract
Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed.

Countries

Netherlands

Subject Area

tuberculosisdiagnostics

Languages

English
DOI
10.1371/journal.pone.0033704
Published Date
19 Mar 2012
PubMed ID
22442713
Journal
PLOS One
Volume | Issue | Pages
Volume 7, Issue 3
Issue Date
2012-03-19
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