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Journal Article > Research

TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs

Kosack CS, Page AL, Van Hulsteijn LT, Lentjes EG
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Abstract
Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed.
Countries
Netherlands
Subject Area
tuberculosisdiagnostics
DOI
10.1371/journal.pone.0033704
Published Date
19-Mar-2012
PubMed ID
22442713
Languages
English
Journal
PLOS One
Volume / Issue / Pages
Volume 7, Issue 3
Issue Date
19-Mar-2012
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