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Journal Article > Research

Transcriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virus

Liu X, Speranza E, Munoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Ludtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny JG, Rockliffe N, Williamson ED, Laws TR, NFaly M, Matthews DA, Gunther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA
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Abstract
In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality.
Countries
Guinea
Subject Area
Ebola
DOI
10.1186/s13059-016-1137-3
Published Date
19-Jan-2017
PubMed ID
28100256
Languages
English
Journal
Genome Biology
Volume / Issue / Pages
Volume 18, Issue 1
Issue Date
19-Jan-2017
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