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The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy | Journal Article / Research | MSF Science Portal
Journal Article
|Research

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy

Byakwaga H, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW
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Abstract
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown.

Countries

Uganda

Subject Area

HIV/AIDS

Languages

English
DOI
1;210(3):383-91
Published Date
28 Feb 2014
PubMed ID
24585899
Journal
Journal of Infectious Diseases
Volume | Issue | Pages
Volume null Issue 3
Issue Date
2014-02-28
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